40432

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1232086..1232651 Replicon chromosome
Accession NZ_AP025570
Organism [Clostridium] scindens strain CE91-St60

Toxin (Protein)


Gene name relE Uniprot ID B0NE10
Locus tag MWL94_RS06515 Protein ID WP_004606924.1
Coordinates 1232086..1232376 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A844F6Y3
Locus tag MWL94_RS06520 Protein ID WP_039909695.1
Coordinates 1232373..1232651 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWL94_RS06480 1227484..1228170 + 687 Protein_1265 response regulator transcription factor -
MWL94_RS06485 (CE91St60_12930) 1228167..1229030 + 864 WP_004606931.1 HAMP domain-containing sensor histidine kinase -
MWL94_RS06490 (CE91St60_12940) 1229141..1229671 + 531 WP_004606930.1 ABC transporter ATP-binding protein -
MWL94_RS06495 (CE91St60_12950) 1229959..1230405 + 447 WP_004606929.1 hypothetical protein -
MWL94_RS06500 (CE91St60_12960) 1230455..1230790 + 336 WP_233440761.1 sigma factor-like helix-turn-helix DNA-binding protein -
MWL94_RS06505 (CE91St60_12970) 1230819..1230956 + 138 WP_004606927.1 hypothetical protein -
MWL94_RS06510 (CE91St60_12980) 1230950..1231681 + 732 WP_004606926.1 MobA/MobL family protein -
MWL94_RS18650 (CE91St60_12990) 1231769..1231978 + 210 WP_004606925.1 hypothetical protein -
MWL94_RS06515 (CE91St60_13000) 1232086..1232376 - 291 WP_004606924.1 type II toxin-antitoxin system YafQ family toxin Toxin
MWL94_RS06520 (CE91St60_13010) 1232373..1232651 - 279 WP_039909695.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MWL94_RS06525 1232762..1232923 + 162 WP_004606922.1 hypothetical protein -
MWL94_RS06530 (CE91St60_13030) 1232904..1233302 + 399 WP_039909694.1 cysteine-rich VLP domain-containing protein -
MWL94_RS06535 1233416..1233892 + 477 Protein_1277 phage replisome organizer N-terminal domain-containing protein -
MWL94_RS06540 1233890..1234534 + 645 Protein_1278 CHAP domain-containing protein -
MWL94_RS06545 (CE91St60_13050) 1234675..1235382 + 708 WP_004606919.1 LytTR family DNA-binding domain-containing protein -
MWL94_RS06550 (CE91St60_13060) 1235379..1236665 + 1287 WP_050755140.1 sensor histidine kinase -
MWL94_RS06555 (CE91St60_13070) 1236842..1237528 + 687 WP_004606917.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1230819..1240750 9931


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11154.91 Da        Isoelectric Point: 8.0644

>T40432 WP_004606924.1 NZ_AP025570:c1232376-1232086 [[Clostridium] scindens]
MRETKYTVKYTTSFKKDYKRAIKRGLKIELLEQIVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T40432 NZ_AP025570:c1232376-1232086 [[Clostridium] scindens]
ATGAGAGAAACCAAATATACCGTCAAGTACACGACTAGTTTCAAAAAAGACTACAAACGAGCCATAAAGCGTGGCTTGAA
GATCGAGCTGCTGGAGCAGATCGTAGCACTGCTGGCGATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGACATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10233.64 Da        Isoelectric Point: 4.4692

>AT40432 WP_039909695.1 NZ_AP025570:c1232651-1232373 [[Clostridium] scindens]
MAGNTTNISIRMDADLKAQADALFSELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT40432 NZ_AP025570:c1232651-1232373 [[Clostridium] scindens]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCCCAGGCGGACGCACTGTTTTCGGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAGGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A844F3U5

Antitoxin

Source ID Structure
AlphaFold DB A0A844F6Y3

References