Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1232086..1232651 Replicon chromosome
Accession NZ_AP025570
Organism [Clostridium] scindens strain CE91-St60

Toxin (Protein)


Gene name relE Uniprot ID B0NE10
Locus tag MWL94_RS06515 Protein ID WP_004606924.1
Coordinates 1232086..1232376 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A844F6Y3
Locus tag MWL94_RS06520 Protein ID WP_039909695.1
Coordinates 1232373..1232651 (-) Length 93 a.a.

Genomic Context

MWL94_RS06480MWL94_RS06485MWL94_RS06490MWL94_RS06495MWL94_RS06500MWL94_RS06505MWL94_RS06510MWL94_RS18650MWL94_RS06525MWL94_RS06530MWL94_RS06535MWL94_RS06540MWL94_RS06545MWL94_RS06550MWL94_RS06555MWL94_RS06515MWL94_RS06520
Location: 1227484..1228170 (687 bp)
Type: Others
Protein ID: Protein_1265
Location: 1228167..1229030 (864 bp)
Type: Others
Protein ID: WP_004606931.1
Location: 1229141..1229671 (531 bp)
Type: Others
Protein ID: WP_004606930.1
Location: 1229959..1230405 (447 bp)
Type: Others
Protein ID: WP_004606929.1
Location: 1230455..1230790 (336 bp)
Type: Others
Protein ID: WP_233440761.1
Location: 1230819..1230956 (138 bp)
Type: Others
Protein ID: WP_004606927.1
Location: 1230950..1231681 (732 bp)
Type: Others
Protein ID: WP_004606926.1
Location: 1231769..1231978 (210 bp)
Type: Others
Protein ID: WP_004606925.1
Location: 1232762..1232923 (162 bp)
Type: Others
Protein ID: WP_004606922.1
Location: 1232904..1233302 (399 bp)
Type: Others
Protein ID: WP_039909694.1
Location: 1233416..1233892 (477 bp)
Type: Others
Protein ID: Protein_1277
Location: 1233890..1234534 (645 bp)
Type: Others
Protein ID: Protein_1278
Location: 1234675..1235382 (708 bp)
Type: Others
Protein ID: WP_004606919.1
Location: 1235379..1236665 (1287 bp)
Type: Others
Protein ID: WP_050755140.1
Location: 1236842..1237528 (687 bp)
Type: Others
Protein ID: WP_004606917.1
Location: 1232086..1232376 (291 bp)
Type: Toxin
Protein ID: WP_004606924.1
Location: 1232373..1232651 (279 bp)
Type: Antitoxin
Protein ID: WP_039909695.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MWL94_RS064801227484..1228170+687Protein_1265response regulator transcription factor-
MWL94_RS06485 (CE91St60_12930)1228167..1229030+864WP_004606931.1HAMP domain-containing sensor histidine kinase-
MWL94_RS06490 (CE91St60_12940)1229141..1229671+531WP_004606930.1ABC transporter ATP-binding protein-
MWL94_RS06495 (CE91St60_12950)1229959..1230405+447WP_004606929.1hypothetical protein-
MWL94_RS06500 (CE91St60_12960)1230455..1230790+336WP_233440761.1sigma factor-like helix-turn-helix DNA-binding protein-
MWL94_RS06505 (CE91St60_12970)1230819..1230956+138WP_004606927.1hypothetical protein-
MWL94_RS06510 (CE91St60_12980)1230950..1231681+732WP_004606926.1MobA/MobL family protein-
MWL94_RS18650 (CE91St60_12990)1231769..1231978+210WP_004606925.1hypothetical protein-
MWL94_RS06515 (CE91St60_13000)1232086..1232376-291WP_004606924.1type II toxin-antitoxin system YafQ family toxinToxin
MWL94_RS06520 (CE91St60_13010)1232373..1232651-279WP_039909695.1type II toxin-antitoxin system RelB/DinJ family antitoxinAntitoxin
MWL94_RS065251232762..1232923+162WP_004606922.1hypothetical protein-
MWL94_RS06530 (CE91St60_13030)1232904..1233302+399WP_039909694.1cysteine-rich VLP domain-containing protein-
MWL94_RS065351233416..1233892+477Protein_1277phage replisome organizer N-terminal domain-containing protein-
MWL94_RS065401233890..1234534+645Protein_1278CHAP domain-containing protein-
MWL94_RS06545 (CE91St60_13050)1234675..1235382+708WP_004606919.1LytTR family DNA-binding domain-containing protein-
MWL94_RS06550 (CE91St60_13060)1235379..1236665+1287WP_050755140.1sensor histidine kinase-
MWL94_RS06555 (CE91St60_13070)1236842..1237528+687WP_004606917.1ABC transporter ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island--1230819..12407509931


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11154.91 Da        Isoelectric Point: 8.0644

>T40432 WP_004606924.1 NZ_AP025570:c1232376-1232086 [[Clostridium] scindens]
MRETKYTVKYTTSFKKDYKRAIKRGLKIELLEQIVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T40432 NZ_AP025570:c1232376-1232086 [[Clostridium] scindens]
ATGAGAGAAACCAAATATACCGTCAAGTACACGACTAGTTTCAAAAAAGACTACAAACGAGCCATAAAGCGTGGCTTGAA
GATCGAGCTGCTGGAGCAGATCGTAGCACTGCTGGCGATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGACATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10233.64 Da        Isoelectric Point: 4.4692

>AT40432 WP_039909695.1 NZ_AP025570:c1232651-1232373 [[Clostridium] scindens]
MAGNTTNISIRMDADLKAQADALFSELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT40432 NZ_AP025570:c1232651-1232373 [[Clostridium] scindens]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCCCAGGCGGACGCACTGTTTTCGGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAGGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A844F3U5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A844F6Y3

References