Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1232085..1232650 Replicon chromosome
Accession NZ_AP025569
Organism [Clostridium] scindens strain CE91-St59

Toxin (Protein)


Gene name relE Uniprot ID B0NE10
Locus tag MWL93_RS06510 Protein ID WP_004606924.1
Coordinates 1232085..1232375 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A844F6Y3
Locus tag MWL93_RS06515 Protein ID WP_039909695.1
Coordinates 1232372..1232650 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWL93_RS06475 1227483..1228169 + 687 Protein_1264 response regulator transcription factor -
MWL93_RS06480 (CE91St59_12780) 1228166..1229029 + 864 WP_004606931.1 HAMP domain-containing sensor histidine kinase -
MWL93_RS06485 (CE91St59_12790) 1229140..1229670 + 531 WP_004606930.1 ABC transporter ATP-binding protein -
MWL93_RS06490 (CE91St59_12800) 1229958..1230404 + 447 WP_004606929.1 hypothetical protein -
MWL93_RS06495 (CE91St59_12810) 1230454..1230789 + 336 WP_233440761.1 sigma factor-like helix-turn-helix DNA-binding protein -
MWL93_RS06500 (CE91St59_12820) 1230818..1230955 + 138 WP_004606927.1 hypothetical protein -
MWL93_RS06505 (CE91St59_12830) 1230949..1231680 + 732 WP_004606926.1 MobA/MobL family protein -
MWL93_RS18640 (CE91St59_12840) 1231768..1231977 + 210 WP_004606925.1 hypothetical protein -
MWL93_RS06510 (CE91St59_12850) 1232085..1232375 - 291 WP_004606924.1 type II toxin-antitoxin system YafQ family toxin Toxin
MWL93_RS06515 (CE91St59_12860) 1232372..1232650 - 279 WP_039909695.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MWL93_RS06520 (CE91St59_12870) 1232761..1232922 + 162 WP_004606922.1 hypothetical protein -
MWL93_RS06525 (CE91St59_12880) 1232903..1233301 + 399 WP_039909694.1 cysteine-rich VLP domain-containing protein -
MWL93_RS06530 1233415..1233891 + 477 Protein_1276 phage replisome organizer N-terminal domain-containing protein -
MWL93_RS06535 1233889..1234533 + 645 Protein_1277 CHAP domain-containing protein -
MWL93_RS06540 (CE91St59_12900) 1234674..1235381 + 708 WP_004606919.1 LytTR family DNA-binding domain-containing protein -
MWL93_RS06545 (CE91St59_12910) 1235378..1236664 + 1287 WP_050755140.1 sensor histidine kinase -
MWL93_RS06550 (CE91St59_12920) 1236841..1237527 + 687 WP_004606917.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-73)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11154.91 Da        Isoelectric Point: 8.0644

>T40431 WP_004606924.1 NZ_AP025569:c1232375-1232085 [[Clostridium] scindens]
MRETKYTVKYTTSFKKDYKRAIKRGLKIELLEQIVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T40431 NZ_AP025569:c1232375-1232085 [[Clostridium] scindens]
ATGAGAGAAACCAAATATACCGTCAAGTACACGACTAGTTTCAAAAAAGACTACAAACGAGCCATAAAGCGTGGCTTGAA
GATCGAGCTGCTGGAGCAGATCGTAGCACTGCTGGCGATGGGCGAACCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGACATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10233.64 Da        Isoelectric Point: 4.4692

>AT40431 WP_039909695.1 NZ_AP025569:c1232650-1232372 [[Clostridium] scindens]
MAGNTTNISIRMDADLKAQADALFSELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT40431 NZ_AP025569:c1232650-1232372 [[Clostridium] scindens]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCCCAGGCGGACGCACTGTTTTCGGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAGGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGCTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A844F3U5

Antitoxin

Source ID Structure
AlphaFold DB A0A844F6Y3

References