Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 4151074..4151639 Replicon chromosome
Accession NZ_AP025565
Organism [Clostridium] innocuum strain CE91-St51

Toxin (Protein)


Gene name relE Uniprot ID C7H6P5
Locus tag MWM11_RS20270 Protein ID WP_002596328.1
Coordinates 4151349..4151639 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C7H6P4
Locus tag MWM11_RS20265 Protein ID WP_005924829.1
Coordinates 4151074..4151352 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWM11_RS20230 (CE91St51_40880) 4146797..4147015 - 219 WP_003525154.1 Maff2 family protein -
MWM11_RS24840 4147055..4147180 - 126 WP_006059576.1 hypothetical protein -
MWM11_RS20235 (CE91St51_40890) 4147235..4148050 - 816 Protein_4011 TraM recognition domain-containing protein -
MWM11_RS20240 (CE91St51_40900) 4148145..4148510 - 366 WP_044942678.1 hypothetical protein -
MWM11_RS20245 (CE91St51_40910) 4148588..4148782 - 195 WP_044942676.1 transposon-encoded TnpW family protein -
MWM11_RS20250 (CE91St51_40920) 4148826..4149689 - 864 WP_044942674.1 ATP-binding protein -
MWM11_RS20255 (CE91St51_40930) 4149686..4150435 - 750 WP_044942671.1 phage replisome organizer N-terminal domain-containing protein -
MWM11_RS20260 (CE91St51_40940) 4150549..4150947 - 399 WP_044942669.1 cysteine-rich VLP domain-containing protein -
MWM11_RS20265 (CE91St51_40950) 4151074..4151352 + 279 WP_005924829.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MWM11_RS20270 (CE91St51_40960) 4151349..4151639 + 291 WP_002596328.1 type II toxin-antitoxin system YafQ family toxin Toxin
MWM11_RS20275 (CE91St51_40970) 4151747..4153192 - 1446 WP_084171680.1 MobQ family relaxase -
MWM11_RS20280 (CE91St51_40990) 4153379..4153669 - 291 WP_244343119.1 DUF3847 domain-containing protein -
MWM11_RS20285 (CE91St51_41000) 4153698..4154159 - 462 WP_244343799.1 sigma factor-like helix-turn-helix DNA-binding protein -
MWM11_RS20290 (CE91St51_41010) 4154170..4154622 - 453 WP_244343798.1 RNA polymerase subunit sigma-24 -
MWM11_RS20295 (CE91St51_41020) 4154726..4155139 - 414 WP_024724760.1 sigma factor-like helix-turn-helix DNA-binding protein -
MWM11_RS20300 (CE91St51_41040) 4155618..4155989 - 372 WP_110441558.1 metal-dependent transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4147235..4169379 22144


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11112.87 Da        Isoelectric Point: 8.0630

>T40429 WP_002596328.1 NZ_AP025565:4151349-4151639 [[Clostridium] innocuum]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T40429 NZ_AP025565:4151349-4151639 [[Clostridium] innocuum]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAAGACTACAAACGAGCCATCAAGCGCGGCTTGAA
GATCGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAGCCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGCCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10247.66 Da        Isoelectric Point: 4.4692

>AT40429 WP_005924829.1 NZ_AP025565:4151074-4151352 [[Clostridium] innocuum]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT40429 NZ_AP025565:4151074-4151352 [[Clostridium] innocuum]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGTTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4XBM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4XB19

References