Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 3600452..3601017 Replicon chromosome
Accession NZ_AP025565
Organism [Clostridium] innocuum strain CE91-St51

Toxin (Protein)


Gene name relE Uniprot ID C7H6P5
Locus tag MWM11_RS17525 Protein ID WP_002596328.1
Coordinates 3600452..3600742 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C7H6P4
Locus tag MWM11_RS17530 Protein ID WP_005924829.1
Coordinates 3600739..3601017 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWM11_RS17495 (CE91St51_35520) 3596102..3596473 + 372 WP_110441558.1 metal-dependent transcriptional regulator -
MWM11_RS17500 (CE91St51_35540) 3596952..3597365 + 414 WP_024724760.1 sigma factor-like helix-turn-helix DNA-binding protein -
MWM11_RS17505 (CE91St51_35550) 3597469..3597921 + 453 WP_244343798.1 RNA polymerase subunit sigma-24 -
MWM11_RS17510 (CE91St51_35560) 3597932..3598393 + 462 WP_244343799.1 sigma factor-like helix-turn-helix DNA-binding protein -
MWM11_RS17515 (CE91St51_35570) 3598422..3598712 + 291 WP_244343119.1 DUF3847 domain-containing protein -
MWM11_RS17520 (CE91St51_35590) 3598899..3600344 + 1446 WP_084171680.1 MobQ family relaxase -
MWM11_RS17525 (CE91St51_35600) 3600452..3600742 - 291 WP_002596328.1 type II toxin-antitoxin system YafQ family toxin Toxin
MWM11_RS17530 (CE91St51_35610) 3600739..3601017 - 279 WP_005924829.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MWM11_RS17535 (CE91St51_35620) 3601144..3601542 + 399 WP_044942669.1 cysteine-rich VLP domain-containing protein -
MWM11_RS17540 (CE91St51_35630) 3601656..3602405 + 750 WP_044942671.1 phage replisome organizer N-terminal domain-containing protein -
MWM11_RS17545 (CE91St51_35640) 3602402..3603265 + 864 WP_044942674.1 ATP-binding protein -
MWM11_RS17550 (CE91St51_35650) 3603309..3603503 + 195 WP_044942676.1 transposon-encoded TnpW family protein -
MWM11_RS17555 (CE91St51_35660) 3603581..3603946 + 366 WP_044942678.1 hypothetical protein -
MWM11_RS17560 (CE91St51_35670) 3604041..3604856 + 816 Protein_3491 TraM recognition domain-containing protein -
MWM11_RS24820 3604911..3605036 + 126 WP_006059576.1 hypothetical protein -
MWM11_RS17565 (CE91St51_35680) 3605076..3605294 + 219 WP_003525154.1 Maff2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11112.87 Da        Isoelectric Point: 8.0630

>T40428 WP_002596328.1 NZ_AP025565:c3600742-3600452 [[Clostridium] innocuum]
MKETKYTVKYTTSFKKDYKRAIKRGLKIELLEQVVALLAMGEPLPDKNRDHDLSGDWAGHRECHILPDWLLVYRIEDDVL
VLTLARTGTHSDLFGK

Download         Length: 291 bp

>T40428 NZ_AP025565:c3600742-3600452 [[Clostridium] innocuum]
ATGAAAGAAACCAAATATACCGTCAAGTACACGACCAGTTTCAAAAAAGACTACAAACGAGCCATCAAGCGCGGCTTGAA
GATCGAGCTGCTGGAGCAGGTCGTAGCATTGCTGGCAATGGGCGAGCCGCTGCCGGATAAGAACCGTGACCATGACCTGT
CCGGCGATTGGGCAGGCCATCGGGAATGTCATATTCTCCCGGACTGGCTGCTTGTCTACCGCATAGAGGATGATGTTCTG
GTGCTGACGCTGGCCCGCACCGGCACACACAGCGACTTGTTCGGCAAATAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10247.66 Da        Isoelectric Point: 4.4692

>AT40428 WP_005924829.1 NZ_AP025565:c3601017-3600739 [[Clostridium] innocuum]
MAGNTTNISIRMDADLKAQADALFTELGMNLTTAFNIFVRQSLREGGIPFEVRLEQPNKETVAAMLEAERIAKDPSVKGY
NDLDELFADLKR

Download         Length: 279 bp

>AT40428 NZ_AP025565:c3601017-3600739 [[Clostridium] innocuum]
ATGGCTGGAAATACCACAAACATCAGTATCCGCATGGACGCAGATTTGAAAGCGCAGGCGGACGCACTGTTTACTGAACT
TGGCATGAACCTGACTACGGCGTTTAACATCTTTGTGCGCCAGTCGCTTCGTGAAGGCGGCATTCCCTTTGAAGTAAGGC
TGGAACAGCCGAACAAAGAAACGGTTGCTGCCATGCTGGAAGCGGAAAGGATTGCAAAAGACCCGTCTGTAAAGGGTTAC
AATGACCTTGACGAGTTGTTTGCTGACCTGAAAAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M4XBM1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M4XB19

References