Detailed information of TA system TA040427

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2833379..2833907
• Replicon: chromosome
• Accession: NZ_AP025565
• Organism: [Clostridium] innocuum strain CE91-St51

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MWM11_RS13675
• Protein ID: WP_216881149.1
• Coordinates: 2833629..2833907 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MWM11_RS13670
• Protein ID: WP_216880959.1
• Coordinates: 2833379..2833642 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MWM11_RS13645 (CE91St51_27780)	2828652..2829656	+	1005	WP_217780936.1	M23 family metallopeptidase	-
MWM11_RS13650 (CE91St51_27790)	2829653..2830213	+	561	WP_054344101.1	hypothetical protein	-
MWM11_RS13655 (CE91St51_27800)	2830155..2830955	+	801	WP_216880968.1	hypothetical protein	-
MWM11_RS13660 (CE91St51_27810)	2830959..2832095	+	1137	WP_244342800.1	FtsK/SpoIIIE domain-containing protein	-
MWM11_RS13665 (CE91St51_27820)	2832222..2833028	+	807	WP_216880961.1	hypothetical protein	-
MWM11_RS13670 (CE91St51_27830)	2833379..2833642	+	264	WP_216880959.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MWM11_RS13675 (CE91St51_27840)	2833629..2833907	+	279	WP_216881149.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MWM11_RS13680 (CE91St51_27850)	2833945..2834175	-	231	WP_216881152.1	hypothetical protein	-
MWM11_RS13685 (CE91St51_27860)	2834336..2834551	+	216	WP_216880957.1	hypothetical protein	-
MWM11_RS13690 (CE91St51_27870)	2834605..2834907	+	303	WP_216880955.1	hypothetical protein	-
MWM11_RS13695 (CE91St51_27880)	2834919..2835176	+	258	WP_216880953.1	hypothetical protein	-
MWM11_RS13700 (CE91St51_27890)	2835226..2835615	+	390	WP_216880951.1	hypothetical protein	-
MWM11_RS13705 (CE91St51_27900)	2835612..2835824	+	213	WP_216880948.1	hypothetical protein	-
MWM11_RS13710 (CE91St51_27910)	2835953..2836111	+	159	WP_216880946.1	hypothetical protein	-
MWM11_RS13715 (CE91St51_27920)	2836309..2837598	+	1290	WP_216880944.1	recombinase family protein	-
MWM11_RS13720 (CE91St51_27930)	2838247..2838609	+	363	WP_008819302.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-82)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10972.87 Da
• Isoelectric Point: 9.8360

>T40427 WP_216881149.1 NZ_AP025565:2833629-2833907 [[Clostridium] innocuum]
MRKIKYENSFKKDFKRIKKRGYKTEKIKAVINMLVNDIELPVEYRDHALTGKYKSRGIRECHIEPDWLLMYIKDNDELLL
ILVGTGTHSDLF

Nucleotide

• Length: 279 bp

>T40427 NZ_AP025565:2833629-2833907 [[Clostridium] innocuum]
ATGAGGAAGATTAAATATGAGAATAGCTTTAAAAAGGATTTTAAGAGAATAAAGAAACGTGGCTATAAAACAGAAAAAAT
AAAAGCGGTTATCAATATGCTAGTAAATGATATTGAATTACCTGTTGAGTATCGTGACCATGCATTGACTGGCAAGTATA
AAAGCAGAGGGATTCGTGAATGTCATATTGAACCAGATTGGTTGTTAATGTATATCAAGGATAATGATGAATTATTACTA
ATATTGGTCGGGACTGGTACTCATTCAGATTTATTTTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10017.24 Da
• Isoelectric Point: 4.0949

>AT40427 WP_216880959.1 NZ_AP025565:2833379-2833642 [[Clostridium] innocuum]
MATISVRIDDDLKKETEEVCNELGLNMSTAVTIFLKKLCREQRIPFEVSMYNKSTTQAIENALNGMNLSKEFHNVDELFE
DLNDEED

Nucleotide

• Length: 264 bp

>AT40427 NZ_AP025565:2833379-2833642 [[Clostridium] innocuum]
ATGGCAACGATAAGTGTGAGAATTGATGATGATTTAAAAAAAGAAACAGAAGAGGTATGTAATGAACTAGGTTTAAATAT
GTCAACCGCTGTAACGATTTTCCTAAAAAAATTGTGTAGAGAACAGCGTATTCCCTTTGAGGTATCAATGTATAACAAAA
GCACAACACAAGCTATAGAGAATGCTTTGAATGGAATGAATTTAAGTAAAGAGTTCCATAATGTTGATGAATTGTTTGAG
GATTTGAATGATGAGGAAGATTAA