Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 6490393..6492076 Replicon chromosome
Accession NZ_AP025556
Organism Delftia lacustris strain HQS1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HQS1_RS29685 Protein ID WP_034363418.1
Coordinates 6491222..6492076 (-) Length 285 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HQS1_RS29680 Protein ID WP_126311145.1
Coordinates 6490393..6491199 (-) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQS1_RS29650 (HQS1_58680) 6486044..6486814 - 771 WP_012202888.1 SDR family oxidoreductase -
HQS1_RS29655 (HQS1_58690) 6487469..6487744 + 276 WP_074931722.1 hypothetical protein -
HQS1_RS29660 6488008..6488346 + 339 Protein_5844 type II toxin-antitoxin system RelE/ParE family toxin -
HQS1_RS29665 6488347..6488655 + 309 WP_034363421.1 XRE family transcriptional regulator -
HQS1_RS29670 (HQS1_58710) 6488668..6489429 - 762 WP_013804513.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
HQS1_RS29675 (HQS1_58720) 6489541..6490338 - 798 WP_034363548.1 aspartate dehydrogenase -
HQS1_RS29680 (HQS1_58730) 6490393..6491199 - 807 WP_126311145.1 IclR family transcriptional regulator Antitoxin
HQS1_RS29685 (HQS1_58740) 6491222..6492076 - 855 WP_034363418.1 alpha/beta fold hydrolase Toxin
HQS1_RS29690 (HQS1_58750) 6492091..6492621 - 531 WP_016449821.1 cupin domain-containing protein -
HQS1_RS29695 (HQS1_58760) 6492821..6494017 - 1197 WP_034363546.1 MFS transporter -
HQS1_RS29700 (HQS1_58770) 6494040..6494924 - 885 WP_034363416.1 NAD(P)-dependent oxidoreductase -
HQS1_RS29705 (HQS1_58780) 6495061..6495651 - 591 WP_013804518.1 TetR/AcrR family transcriptional regulator -
HQS1_RS29710 (HQS1_58790) 6495733..6496224 - 492 WP_016449824.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(43-270)

Antitoxin

Transcription regulator IclR, C-terminal

(137-255)


Sequences

Toxin        


Download         Length: 285 a.a.        Molecular weight: 29671.00 Da        Isoelectric Point: 7.1057

>T40422 WP_034363418.1 NZ_AP025556:c6492076-6491222 [Delftia lacustris]
MTAQTLQRMEQRLQAQFPEHLIALPGGAQVAWREAGDTASDFAVVMLHGISSGAASWMDVALALAPRTRVLAWDAPGYGR
STPLAPAAPTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAEGHLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Download         Length: 855 bp

>T40422 NZ_AP025556:c6492076-6491222 [Delftia lacustris]
ATGACCGCGCAGACGCTGCAGCGCATGGAGCAGCGCCTTCAGGCGCAGTTCCCCGAACACCTCATCGCCCTGCCCGGGGG
CGCCCAGGTCGCCTGGCGCGAGGCCGGCGACACGGCCTCGGACTTTGCCGTGGTGATGCTGCATGGCATCAGCTCGGGCG
CCGCGTCCTGGATGGACGTGGCCCTGGCGCTGGCGCCGCGCACGCGTGTGCTGGCCTGGGACGCGCCCGGCTATGGCCGC
TCCACGCCGCTGGCACCCGCCGCGCCCACGGGCGCCGACTACGCCCGCGTGCTGGAGCAGTCGCTGCAGGCGCTGGGCGT
GCGCCGCTGCCTGCTGGTGGGCCACTCGCTGGGTGCGCTCATGGGCACGCCCTGGGCGGTGCAGGCCGGTGCCGGGCGCG
TGCAGCAACTGGTGCTGATCAGCCCCGCTGGCGGCTATGGCGCACCCGGCATGGGCGAGCAGCAGGCCAAGGTACGCCAG
GGCCGTCTTGCGGCCCTGCAGGAAAAAGGCATCGAAGGCCTGGCTGCCGCCATCGACCAGCGCCTGGTCTCGCCCGCCGC
GCCCGAGCCCGTGCGCCAATGGGTGCGCTGGAACACGGCGCGCCTGCATGCCGCAGGCTACGCCCAGGCCGTGGAGCTGC
TGTGCGGCAGCGACCTGGGGCAGGCGGAGGGGCACCTTGCCATGCCGGTCGAGGTCTGGGTGGGAGAGCACGACGTCGTC
ACGCCGCCGGCTGCCTGCGCGGCCTGGGCCGCAAGACTGGGGGCGCGGTACGTTACGCTTGCGGCAGCCGGCCATGCCTC
TGTCGTCGAACAACCTGCGGATGTCGCACAGAGGCTGGCCACCCTGCTGACCTGA

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29034.08 Da        Isoelectric Point: 5.3408

>AT40422 WP_126311145.1 NZ_AP025556:c6491199-6490393 [Delftia lacustris]
MSDTSETLSTDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLEGMGYLQRSGTEYRLGLAVL
RLGYDYLSTQPLAQLAEPVLQSLCDRLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRALFGGSELPQFSESTPRSVEQLLQLLQQDHERGYAMGEGFYEPGVSSIAAPVRDAQGRIVAGLGMAVAFTEIAPGR
MADWVEQVRAAADELAGHLRTQHPGFLR

Download         Length: 807 bp

>AT40422 NZ_AP025556:c6491199-6490393 [Delftia lacustris]
ATGAGCGATACCTCCGAAACCCTCTCCACCGACAACGACCGCTACACCGTTCCCGCGCTGGAGCGCGGCCTGCGCCTGCT
GGCCTGCTTCACGCCTTCGCAGCCCGTGTGGAGCGCGCCCGACCTGGCGCGCACCCTGGCGCTGCCCCGGTCCACGGTGT
TCCGGATGCTGACGACGCTGGAGGGCATGGGGTATCTGCAACGCTCGGGCACCGAATACCGGCTGGGCCTGGCCGTGCTG
CGCCTGGGCTACGACTACCTGTCCACCCAGCCGCTGGCCCAGCTGGCCGAGCCCGTGCTGCAGTCGCTGTGCGACCGGCT
GGGCTTCACCACCAACCTGGCGCTGCTGGACGGCACCTCCGTGGTCTATGTGGCGCGCATCGCGCCGGCCGGCGCCTTCC
AGGGCGCCGTGCGCGTGGGCTCGCGGCTGCCGGCCCATGCCACCGTGCTGGGCCGGGCACTGCTGCAGGACATGGACGCG
GACCAGCTGCGCGCCCTGTTCGGCGGCAGCGAACTGCCCCAGTTCTCGGAAAGCACGCCGCGCAGCGTGGAACAGTTGCT
GCAGTTGCTGCAGCAGGACCATGAACGCGGCTACGCCATGGGCGAGGGCTTCTACGAGCCCGGCGTCTCCAGCATCGCCG
CGCCCGTGCGCGATGCGCAGGGGCGCATCGTGGCGGGCCTGGGCATGGCCGTGGCCTTCACCGAAATCGCTCCCGGCCGC
ATGGCCGACTGGGTGGAGCAGGTACGTGCCGCCGCCGATGAGCTGGCCGGCCACCTGCGCACCCAGCATCCCGGTTTTCT
GCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References