Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4322297..4323339 Replicon chromosome
Accession NZ_AP025556
Organism Delftia lacustris strain HQS1

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag HQS1_RS19565 Protein ID WP_003109777.1
Coordinates 4322297..4322872 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID I3TV68
Locus tag HQS1_RS19570 Protein ID WP_003050245.1
Coordinates 4322869..4323339 (-) Length 157 a.a.

Genomic Context

HQS1_RS19575HQS1_RS19580HQS1_RS19585HQS1_RS19590HQS1_RS19595HQS1_RS19600HQS1_RS19605HQS1_RS19540HQS1_RS19545HQS1_RS19550HQS1_RS19555HQS1_RS19560HQS1_RS19565HQS1_RS19570
Location: 4323543..4323926 (384 bp)
Type: Others
Protein ID: WP_003120001.1
Location: 4323923..4324156 (234 bp)
Type: Others
Protein ID: WP_003050225.1
Location: 4324173..4324532 (360 bp)
Type: Others
Protein ID: WP_003090173.1
Location: 4324544..4324942 (399 bp)
Type: Others
Protein ID: WP_003105639.1
Location: 4324939..4325631 (693 bp)
Type: Others
Protein ID: WP_003105641.1
Location: 4325628..4326539 (912 bp)
Type: Others
Protein ID: WP_003105643.1
Location: 4326529..4327947 (1419 bp)
Type: Others
Protein ID: WP_020924934.1
Location: 4318735..4319460 (726 bp)
Type: Others
Protein ID: WP_003050273.1
Location: 4319499..4320401 (903 bp)
Type: Others
Protein ID: WP_003105624.1
Location: 4320401..4320901 (501 bp)
Type: Others
Protein ID: WP_003090159.1
Location: 4320898..4321368 (471 bp)
Type: Others
Protein ID: WP_003105626.1
Location: 4321365..4322279 (915 bp)
Type: Others
Protein ID: WP_003105629.1
Location: 4322297..4322872 (576 bp)
Type: Toxin
Protein ID: WP_003109777.1
Location: 4322869..4323339 (471 bp)
Type: Antitoxin
Protein ID: WP_003050245.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HQS1_RS19540 (HQS1_38450)4318735..4319460-726WP_003050273.1CBASS effector endonuclease NucC-
HQS1_RS19545 (HQS1_38460)4319499..4320401-903WP_003105624.1CBASS oligonucleotide cyclase-
HQS1_RS19550 (HQS1_38470)4320401..4320901-501WP_003090159.1type III CBASS phage resistance system CD-NTase-associated protein Cap7-
HQS1_RS19555 (HQS1_38480)4320898..4321368-471WP_003105626.1type III CBASS phage resistance system CD-NTase-associated protein Cap8-
HQS1_RS19560 (HQS1_38490)4321365..4322279-915WP_003105629.1AAA family ATPase-
HQS1_RS19565 (HQS1_38500)4322297..4322872-576WP_003109777.1PIN domain-containing proteinToxin
HQS1_RS19570 (HQS1_38510)4322869..4323339-471WP_003050245.1helix-turn-helix domain-containing proteinAntitoxin
HQS1_RS19575 (HQS1_38520)4323543..4323926+384WP_003120001.1RAQPRD family integrative conjugative element protein-
HQS1_RS19580 (HQS1_38530)4323923..4324156+234WP_003050225.1TIGR03758 family integrating conjugative element protein-
HQS1_RS19585 (HQS1_38540)4324173..4324532+360WP_003090173.1TIGR03745 family integrating conjugative element membrane protein-
HQS1_RS19590 (HQS1_38550)4324544..4324942+399WP_003105639.1TIGR03750 family conjugal transfer protein-
HQS1_RS19595 (HQS1_38560)4324939..4325631+693WP_003105641.1TIGR03746 family integrating conjugative element protein-
HQS1_RS19600 (HQS1_38570)4325628..4326539+912WP_003105643.1TIGR03749 family integrating conjugative element protein-
HQS1_RS19605 (HQS1_38580)4326529..4327947+1419WP_020924934.1TIGR03752 family integrating conjugative element protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element--4270151..436367393522


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-114)

Antitoxin

Helix-turn-helix domain, group 17

(85-133)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21644.79 Da        Isoelectric Point: 5.6172

>T40420 WP_003109777.1 NZ_AP025556:c4322872-4322297 [Delftia lacustris]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL

Download         Length: 576 bp

>T40420 NZ_AP025556:c4322872-4322297 [Delftia lacustris]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACCGGGCAATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTGCCCGATCCGGACGACCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGGGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTACTGGATCTGGACGCGGCCGCCGTGGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGAGGTGGACCGCTATCTCGAAATCCTGCTGCGCCAGGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17245.62 Da        Isoelectric Point: 6.3803

>AT40420 WP_003050245.1 NZ_AP025556:c4323339-4322869 [Delftia lacustris]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE

Download         Length: 471 bp

>AT40420 NZ_AP025556:c4323339-4322869 [Delftia lacustris]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTGAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTCGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBI3TV68

References