Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2457307..2458016 Replicon chromosome
Accession NZ_AP025556
Organism Delftia lacustris strain HQS1

Toxin (Protein)


Gene name vapC Uniprot ID A0A072TA84
Locus tag HQS1_RS11105 Protein ID WP_034367439.1
Coordinates 2457307..2457753 (-) Length 149 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1I0X5K2
Locus tag HQS1_RS11110 Protein ID WP_016448241.1
Coordinates 2457750..2458016 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQS1_RS11085 (HQS1_21760) 2452905..2454119 + 1215 WP_017406195.1 ABC transporter permease -
HQS1_RS11090 (HQS1_21770) 2454121..2455266 + 1146 WP_244388022.1 ABC transporter permease -
HQS1_RS11095 (HQS1_21780) 2455330..2455959 - 630 WP_034367434.1 DUF4124 domain-containing protein -
HQS1_RS11100 (HQS1_21790) 2456038..2457243 - 1206 WP_034367436.1 MFS transporter -
HQS1_RS11105 (HQS1_21800) 2457307..2457753 - 447 WP_034367439.1 type II toxin-antitoxin system VapC family toxin Toxin
HQS1_RS11110 (HQS1_21810) 2457750..2458016 - 267 WP_016448241.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HQS1_RS11115 (HQS1_21820) 2458041..2459012 - 972 WP_034367441.1 LysR family transcriptional regulator -
HQS1_RS11120 (HQS1_21830) 2459083..2459973 + 891 WP_244388023.1 amidohydrolase family protein -
HQS1_RS11125 (HQS1_21840) 2460000..2460995 + 996 WP_016448238.1 tripartite tricarboxylate transporter substrate binding protein -
HQS1_RS11130 (HQS1_21850) 2461021..2462652 - 1632 WP_244388024.1 gamma-glutamyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-133)

Antitoxin

SpoVT-AbrB domain

(8-54)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15850.43 Da        Isoelectric Point: 8.1045

>T40419 WP_034367439.1 NZ_AP025556:c2457753-2457307 [Delftia lacustris]
MTRYLLDTNIASHIIKGDIPAVREQLVRVPMHQIAVSAVTQAELMYGVAKRGHPAGLSLRVTGFLARVEVLPWTAQVADA
YGHLRAACEAAGITLASMDMMIAAHALLLQQQAAQAGERSVLVTRDRVFSRIPEPGLAIADWTTGPAG

Download         Length: 447 bp

>T40419 NZ_AP025556:c2457753-2457307 [Delftia lacustris]
ATGACACGCTACCTGCTGGACACCAACATCGCCAGCCACATCATCAAAGGCGATATCCCTGCCGTGCGCGAACAGCTGGT
TCGCGTACCCATGCACCAGATCGCAGTGTCGGCGGTCACGCAGGCCGAACTGATGTACGGGGTCGCCAAGCGCGGCCACC
CTGCCGGGCTGTCGCTGCGGGTGACAGGGTTCCTGGCCCGCGTCGAGGTGCTGCCCTGGACGGCCCAGGTGGCCGATGCC
TACGGCCACCTGCGCGCCGCTTGCGAGGCGGCCGGCATCACGCTGGCCTCCATGGACATGATGATTGCCGCGCACGCCCT
GCTCCTGCAGCAGCAGGCCGCGCAGGCCGGCGAGCGCTCGGTGCTGGTCACAAGAGACCGGGTGTTCAGCCGCATTCCCG
AACCCGGACTGGCCATCGCGGACTGGACGACCGGCCCGGCTGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10076.08 Da        Isoelectric Point: 4.3846

>AT40419 WP_016448241.1 NZ_AP025556:c2458016-2457750 [Delftia lacustris]
VTQTAKLFTTGRSQAVRLPYEFRFEEKEVYIRRDPVTGDVILSRRPDSWQEFFALDATTDVPADFMDTADRAQPESGRDP
FADEGSTR

Download         Length: 267 bp

>AT40419 NZ_AP025556:c2458016-2457750 [Delftia lacustris]
GTGACGCAGACTGCCAAGCTTTTCACCACCGGTCGCAGCCAGGCCGTGCGCCTTCCCTATGAATTCCGGTTCGAGGAAAA
AGAGGTCTACATACGTCGCGACCCCGTCACGGGCGACGTGATCCTGTCGCGCCGTCCCGACTCATGGCAAGAGTTCTTTG
CGCTCGACGCCACCACCGACGTGCCGGCCGATTTCATGGACACCGCTGACCGAGCGCAGCCAGAGTCAGGCCGCGATCCG
TTTGCCGACGAAGGCAGTACGCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A072TA84

Antitoxin

Source ID Structure
AlphaFold DB A0A1I0X5K2

References