Detailed information of TA system TA040418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 903021..903601
• Replicon: chromosome
• Accession: NZ_AP025556
• Organism: Delftia lacustris strain HQS1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: HQS1_RS04085
• Protein ID: WP_034363334.1
• Coordinates: 903021..903401 (-)
• Length: 127 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A9C0Y1
• Locus tag: HQS1_RS04090
• Protein ID: WP_012207613.1
• Coordinates: 903398..903601 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HQS1_RS04065 (HQS1_07990)	898344..899585	+	1242	WP_016448371.1	ABC transporter substrate-binding protein	-
HQS1_RS04070 (HQS1_08000)	899582..900340	+	759	WP_016452684.1	ABC transporter permease	-
HQS1_RS04075 (HQS1_08010)	900375..901961	-	1587	WP_034363331.1	Ig-like domain repeat protein	-
HQS1_RS04080 (HQS1_08020)	902190..902942	+	753	WP_034363332.1	helix-turn-helix transcriptional regulator	-
HQS1_RS04085 (HQS1_08030)	903021..903401	-	381	WP_034363334.1	type II toxin-antitoxin system VapC family toxin	Toxin
HQS1_RS04090 (HQS1_08040)	903398..903601	-	204	WP_012207613.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
HQS1_RS04095 (HQS1_08050)	903752..904564	+	813	WP_034363336.1	glucose 1-dehydrogenase	-
HQS1_RS04100 (HQS1_08060)	904673..906349	+	1677	WP_034363338.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-114)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-43)

Sequences

Toxin

Protein

• Length: 127 a.a.
• Molecular weight: 13903.28 Da
• Isoelectric Point: 9.4293

>T40418 WP_034363334.1 NZ_AP025556:c903401-903021 [Delftia lacustris]
MNPVLVDTSVWIDHFRQGNPHLAQLLQQDMALMHPLVLGELACGTPPARARTLADLQRLKPARQASMREVLALIEREQLF
GLGCGLVDITLLASALISSGASLWSRDRRLHALAQRFGIAYRSVLP

Nucleotide

• Length: 381 bp

>T40418 NZ_AP025556:c903401-903021 [Delftia lacustris]
ATGAATCCCGTTCTGGTCGATACCTCGGTCTGGATCGATCACTTCAGGCAGGGCAATCCTCACCTGGCGCAGTTGCTGCA
GCAAGACATGGCGCTCATGCATCCCCTGGTGCTGGGTGAACTGGCTTGCGGCACGCCACCGGCACGCGCACGCACGCTCG
CGGACCTTCAGCGGCTCAAGCCTGCCCGGCAGGCCAGCATGCGCGAAGTGCTGGCCTTGATAGAGCGCGAGCAACTCTTT
GGTCTGGGCTGCGGTCTGGTGGACATCACGCTCCTGGCCTCGGCACTCATATCTTCAGGTGCCAGCCTGTGGTCGCGAGA
CAGGCGCCTGCACGCGCTGGCCCAGCGGTTTGGCATTGCCTACCGGAGCGTCTTGCCGTAG

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7485.58 Da
• Isoelectric Point: 4.5702

>AT40418 WP_012207613.1 NZ_AP025556:c903601-903398 [Delftia lacustris]
MRTTVTIDDALYEEALELAEPEMDKADLFREAVKTFVRVQAAKRLAALGGSAPDMREIPRRPQGIEP

Nucleotide

• Length: 204 bp

>AT40418 NZ_AP025556:c903601-903398 [Delftia lacustris]
ATGAGAACCACGGTCACCATCGACGACGCCTTGTACGAGGAAGCGCTGGAGCTGGCGGAGCCAGAAATGGACAAGGCCGA
CCTGTTTCGCGAAGCCGTCAAGACTTTCGTGAGAGTGCAGGCGGCCAAGCGTCTGGCCGCGCTGGGAGGCTCCGCACCGG
ACATGCGGGAGATTCCCCGTCGCCCACAGGGCATCGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A9C0Y1