40411

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3483853..3484471 Replicon chromosome
Accession NZ_AP025551
Organism Escherichia coli strain LR-50

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag QUE19_RS16895 Protein ID WP_001291435.1
Coordinates 3484253..3484471 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag QUE19_RS16890 Protein ID WP_000344800.1
Coordinates 3483853..3484227 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE19_RS16880 (3478942) 3478942..3480135 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
QUE19_RS16885 (3480158) 3480158..3483307 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
QUE19_RS16890 (3483853) 3483853..3484227 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
QUE19_RS16895 (3484253) 3484253..3484471 + 219 WP_001291435.1 HHA domain-containing protein Toxin
QUE19_RS16900 (3484643) 3484643..3485194 + 552 WP_000102564.1 maltose O-acetyltransferase -
QUE19_RS16905 (3485310) 3485310..3485780 + 471 WP_000136192.1 YlaC family protein -
QUE19_RS16910 (3485944) 3485944..3487494 + 1551 WP_286330817.1 cyclic-guanylate-specific phosphodiesterase PdeB -
QUE19_RS16915 (3487536) 3487536..3487889 - 354 WP_000878140.1 DUF1428 domain-containing protein -
QUE19_RS16925 (3488268) 3488268..3488579 + 312 WP_000409911.1 MGMT family protein -
QUE19_RS16930 (3488610) 3488610..3489182 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T40411 WP_001291435.1 NZ_AP025551:3484253-3484471 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T40411 NZ_AP025551:3484253-3484471 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT40411 WP_000344800.1 NZ_AP025551:3483853-3484227 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT40411 NZ_AP025551:3483853-3484227 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References