Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 468865..469517 Replicon chromosome
Accession NZ_AP025540
Organism Thermus thermophilus strain HB8_001

Toxin (Protein)


Gene name vapC Uniprot ID Q5SKZ2
Locus tag QUE39_RS02640 Protein ID WP_011227982.1
Coordinates 468865..469257 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5SKZ1
Locus tag QUE39_RS02645 Protein ID WP_011227983.1
Coordinates 469257..469517 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUE39_RS02615 (TthHB8_05020) 465468..465857 + 390 WP_011227977.1 NADH-quinone oxidoreductase subunit 15 -
QUE39_RS02620 (TthHB8_05030) 465860..466957 - 1098 WP_011227978.1 radical SAM family heme chaperone HemW -
QUE39_RS02625 (TthHB8_05040) 466950..467348 - 399 WP_011227979.1 HEPN domain-containing protein -
QUE39_RS02630 (TthHB8_05050) 467338..467655 - 318 WP_011227980.1 nucleotidyltransferase domain-containing protein -
QUE39_RS02635 (TthHB8_05060) 467660..468880 - 1221 WP_011227981.1 glycerate kinase -
QUE39_RS02640 (TthHB8_05070) 468865..469257 - 393 WP_011227982.1 type II toxin-antitoxin system VapC family toxin Toxin
QUE39_RS02645 (TthHB8_05080) 469257..469517 - 261 WP_011227983.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QUE39_RS02650 (TthHB8_05090) 469550..470806 - 1257 WP_011227984.1 glycolate oxidase subunit GlcF -
QUE39_RS02655 (TthHB8_05100) 470811..471854 - 1044 WP_011227985.1 FAD-binding protein -
QUE39_RS02660 (TthHB8_05110) 471841..473223 - 1383 WP_011227986.1 FAD-linked oxidase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-85)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14636.82 Da        Isoelectric Point: 6.8735

>T40372 WP_011227982.1 NZ_AP025540:c469257-468865 [Thermus thermophilus]
MVLDTSALLGILFREEGYEELLEQLRRTRPHKVAAPTLAEAGIVLGARLGFERVHLLFELLTELQAEIVPFTERHAREAI
SAYRRYGRGKHPAGLNFGDCLSYALARVEGEPLLYKGQGFDRTDLAWKPS

Download         Length: 393 bp

>T40372 NZ_AP025540:c469257-468865 [Thermus thermophilus]
ATGGTGCTGGACACCTCCGCCCTCCTGGGCATTCTCTTCCGGGAAGAAGGGTACGAGGAGCTTCTGGAGCAACTCCGGCG
CACCCGCCCCCACAAGGTGGCCGCGCCCACCCTGGCCGAAGCGGGGATCGTCCTGGGCGCCCGGCTGGGCTTTGAGCGGG
TGCATCTTCTCTTTGAACTCCTAACCGAGCTCCAGGCCGAGATCGTGCCCTTCACCGAAAGGCATGCCCGGGAGGCCATC
TCCGCTTACCGGCGCTACGGGCGGGGCAAGCACCCCGCCGGGCTCAACTTTGGGGACTGCCTGAGCTACGCCCTGGCCCG
GGTGGAGGGGGAACCCCTCCTCTACAAGGGCCAGGGCTTTGACCGGACGGACCTGGCGTGGAAGCCCTCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10086.61 Da        Isoelectric Point: 5.0285

>AT40372 WP_011227983.1 NZ_AP025540:c469517-469257 [Thermus thermophilus]
MALTIRNKEVERLAEEVARLAGETKTEAVRKALEMRLRELQRKRSFDRVIRFLEEEVWPQIPPELLGKGLSKEEEEEILG
YGKEGY

Download         Length: 261 bp

>AT40372 NZ_AP025540:c469517-469257 [Thermus thermophilus]
ATGGCCCTCACCATTCGCAACAAGGAGGTGGAGCGCCTGGCGGAGGAGGTGGCCCGCCTCGCCGGAGAAACCAAGACGGA
GGCCGTAAGGAAGGCCCTGGAGATGCGCCTTAGGGAACTCCAGAGGAAGCGGAGCTTTGACCGGGTGATCCGCTTCCTGG
AGGAGGAGGTCTGGCCCCAGATCCCGCCGGAGCTTTTGGGGAAGGGGCTCTCCAAGGAAGAGGAGGAAGAAATCCTGGGG
TACGGCAAGGAGGGGTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q5SKZ2

Antitoxin

Source ID Structure
AlphaFold DB A0A7R7YHV5

References