Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5651886..5652545 Replicon chromosome
Accession NZ_AP025524
Organism Mycobacterium sp. 20KCMC460

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag MKCMC460_RS25935 Protein ID WP_236977931.1
Coordinates 5651886..5652359 (-) Length 158 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag MKCMC460_RS25940 Protein ID WP_236977932.1
Coordinates 5652366..5652545 (-) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKCMC460_RS25915 (MKCMC460_52040) 5647614..5648081 + 468 WP_236977923.1 VOC family protein -
MKCMC460_RS25920 5648094..5648519 - 426 WP_236977925.1 hypothetical protein -
MKCMC460_RS25925 (MKCMC460_52070) 5648655..5648960 + 306 WP_236977927.1 hypothetical protein -
MKCMC460_RS25930 (MKCMC460_52080) 5648964..5651741 - 2778 WP_236977929.1 LuxR family transcriptional regulator -
MKCMC460_RS25935 (MKCMC460_52090) 5651886..5652359 - 474 WP_236977931.1 SRPBCC family protein Toxin
MKCMC460_RS25940 (MKCMC460_52100) 5652366..5652545 - 180 WP_236977932.1 antitoxin Antitoxin
MKCMC460_RS25945 (MKCMC460_52110) 5652616..5654994 - 2379 WP_236977933.1 cation-translocating P-type ATPase -
MKCMC460_RS25950 (MKCMC460_52120) 5654991..5656571 - 1581 WP_238305034.1 serine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 17128.80 Da        Isoelectric Point: 9.7966

>T40365 WP_236977931.1 NZ_AP025524:c5652359-5651886 [Mycobacterium sp. 20KCMC460]
MAKLSGAIDVPLPPERAWQHASDLSRYKEWLTIHKVWRSTLPEVIEKGTVLESYVEVKGMTNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVSPKDDGSVVGFDVHLGGPALFGPIGMVVAAALRSDISESLQNFVRVFARPDPGTNGDSVLHR

Download         Length: 474 bp

>T40365 NZ_AP025524:c5652359-5651886 [Mycobacterium sp. 20KCMC460]
ATGGCGAAACTGTCGGGAGCCATCGACGTCCCGTTGCCGCCCGAACGGGCGTGGCAACACGCCTCGGATCTGTCCCGGTA
CAAGGAGTGGCTGACCATCCACAAGGTCTGGCGCAGCACCTTGCCCGAGGTCATCGAGAAGGGCACCGTGCTGGAGTCCT
ATGTGGAGGTCAAAGGTATGACCAACCGGATCAAGTGGACGATCGTGCGGTACAAGCCGCCCGAGGGCATGACCCTCAAC
GGCGACGGTGTCGGCGGGGTGAAGGTGAAGCTGATTGCCAAGGTGTCGCCGAAGGACGACGGCTCGGTGGTTGGCTTCGA
CGTCCACCTCGGCGGGCCGGCGCTGTTCGGGCCGATCGGAATGGTGGTGGCCGCCGCGTTGCGCAGCGACATCAGCGAGT
CGCTGCAGAACTTCGTCAGGGTGTTCGCCCGTCCCGATCCCGGTACGAACGGCGACAGCGTTCTGCACCGCTGA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6534.29 Da        Isoelectric Point: 5.6492

>AT40365 WP_236977932.1 NZ_AP025524:c5652545-5652366 [Mycobacterium sp. 20KCMC460]
MGFMDKAKDLLSQNADKVETAINKAGEFVDEKTQHKYSDTIHKVQEEAKKVAAPGEQQG

Download         Length: 180 bp

>AT40365 NZ_AP025524:c5652545-5652366 [Mycobacterium sp. 20KCMC460]
ATGGGTTTCATGGATAAAGCGAAGGACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGCAATCAACAAGGCCGGCGA
ATTCGTCGACGAGAAGACGCAGCACAAATACTCCGACACCATCCACAAGGTGCAGGAGGAAGCCAAGAAGGTCGCCGCAC
CGGGCGAGCAGCAGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References