Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3456295..3456929 Replicon chromosome
Accession NZ_AP025524
Organism Mycobacterium sp. 20KCMC460

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MKCMC460_RS16015 Protein ID WP_238304550.1
Coordinates 3456549..3456929 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MKCMC460_RS16010 Protein ID WP_238304549.1
Coordinates 3456295..3456552 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKCMC460_RS15975 (MKCMC460_31880) 3451850..3452383 + 534 WP_236984115.1 ZIP family metal transporter -
MKCMC460_RS15980 (MKCMC460_31890) 3452503..3452793 - 291 WP_236983345.1 hypothetical protein -
MKCMC460_RS15985 (MKCMC460_31900) 3452971..3453642 - 672 WP_238304546.1 hypothetical protein -
MKCMC460_RS15990 (MKCMC460_31910) 3453753..3454376 + 624 WP_238304547.1 TetR/AcrR family transcriptional regulator -
MKCMC460_RS15995 (MKCMC460_31920) 3454541..3454879 - 339 WP_236983339.1 hypothetical protein -
MKCMC460_RS16000 (MKCMC460_31930) 3455110..3455481 + 372 WP_238306009.1 FHA domain-containing protein -
MKCMC460_RS16005 (MKCMC460_31940) 3455818..3456063 + 246 WP_238304548.1 hypothetical protein -
MKCMC460_RS16010 (MKCMC460_31950) 3456295..3456552 + 258 WP_238304549.1 CopG family transcriptional regulator Antitoxin
MKCMC460_RS16015 (MKCMC460_31960) 3456549..3456929 + 381 WP_238304550.1 type II toxin-antitoxin system VapC family toxin Toxin
MKCMC460_RS16020 (MKCMC460_31970) 3457356..3457562 + 207 WP_238304551.1 DUF2191 domain-containing protein -
MKCMC460_RS16025 (MKCMC460_31980) 3457553..3457978 + 426 WP_238304553.1 PIN domain-containing protein -
MKCMC460_RS16030 (MKCMC460_31990) 3458377..3458859 + 483 WP_255735949.1 HXXEE domain-containing protein -
MKCMC460_RS16035 (MKCMC460_32000) 3458999..3459232 + 234 WP_236983326.1 hypothetical protein -
MKCMC460_RS16040 (MKCMC460_32010) 3459229..3459564 + 336 WP_238304555.1 type II toxin-antitoxin system PemK/MazF family toxin -
MKCMC460_RS16045 (MKCMC460_32020) 3460065..3461740 + 1676 Protein_3188 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3461848..3462639 791


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14107.33 Da        Isoelectric Point: 10.7075

>T40364 WP_238304550.1 NZ_AP025524:3456549-3456929 [Mycobacterium sp. 20KCMC460]
MMLVDSDILIAHLRGRAAARDWLRDARGEGPLAISVVSISELVGGMRSAERREVWQLLASFRAEPATEIIARRAGDFMRR
YQRSHSGIGLGDYLVAATADVKGYEPATLNVKHFPMFKNLRPPFRL

Download         Length: 381 bp

>T40364 NZ_AP025524:3456549-3456929 [Mycobacterium sp. 20KCMC460]
ATGATGCTGGTCGACTCAGACATCCTCATCGCCCACCTCCGTGGCAGGGCCGCGGCGCGTGATTGGCTTCGTGATGCTCG
GGGGGAGGGGCCGTTAGCGATCAGCGTGGTGTCGATTAGCGAACTGGTCGGCGGGATGCGCAGCGCGGAGCGGCGCGAGG
TATGGCAGCTGCTCGCGTCGTTTCGTGCCGAACCGGCCACCGAGATCATCGCGCGGCGGGCCGGTGACTTCATGCGCCGG
TATCAACGGAGTCATAGCGGTATCGGTTTGGGTGACTATCTGGTTGCTGCGACCGCCGACGTCAAGGGTTATGAGCCGGC
GACGCTGAACGTGAAGCATTTCCCGATGTTCAAGAACCTGCGGCCGCCATTCAGACTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9772.91 Da        Isoelectric Point: 5.1342

>AT40364 WP_238304549.1 NZ_AP025524:3456295-3456552 [Mycobacterium sp. 20KCMC460]
MKRTNIYLDEAQTISLDKLAEQQGISRAELIRQLLDRALNNADDNLAADLKAIDDSFGVLRDVEAPDRRPGSREQHLERM
WRHTS

Download         Length: 258 bp

>AT40364 NZ_AP025524:3456295-3456552 [Mycobacterium sp. 20KCMC460]
ATGAAGCGCACCAATATCTATCTCGACGAGGCCCAGACAATCAGCCTCGACAAGTTGGCCGAGCAACAAGGCATTTCCCG
CGCCGAGCTCATTCGCCAGCTGTTGGATCGCGCTCTCAACAACGCAGACGACAACCTTGCTGCCGACCTCAAAGCGATTG
ACGATTCGTTCGGCGTTCTGCGCGATGTCGAGGCACCCGATCGTCGACCCGGCAGCCGCGAGCAGCATCTCGAGCGGATG
TGGCGCCACACGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References