Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2892757..2893370 Replicon chromosome
Accession NZ_AP025524
Organism Mycobacterium sp. 20KCMC460

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MKCMC460_RS13525 Protein ID WP_236975464.1
Coordinates 2892966..2893370 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MKCMC460_RS13520 Protein ID WP_236975466.1
Coordinates 2892757..2892969 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKCMC460_RS13490 (MKCMC460_26860) 2888027..2888287 + 261 WP_236975483.1 hypothetical protein -
MKCMC460_RS13495 (MKCMC460_26870) 2888323..2889606 + 1284 WP_238305861.1 threonine ammonia-lyase -
MKCMC460_RS13500 (MKCMC460_26880) 2889623..2890258 - 636 WP_236975480.1 pyridoxamine 5'-phosphate oxidase family protein -
MKCMC460_RS13505 (MKCMC460_26890) 2890299..2891624 + 1326 WP_236975478.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
MKCMC460_RS13510 (MKCMC460_26900) 2891626..2891919 - 294 WP_238305863.1 hypothetical protein -
MKCMC460_RS13515 (MKCMC460_26910) 2891978..2892727 + 750 WP_236975468.1 peroxide stress protein YaaA -
MKCMC460_RS13520 (MKCMC460_26920) 2892757..2892969 + 213 WP_236975466.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MKCMC460_RS13525 (MKCMC460_26930) 2892966..2893370 + 405 WP_236975464.1 PIN domain nuclease Toxin
MKCMC460_RS13530 (MKCMC460_26940) 2893519..2894106 + 588 WP_236975462.1 hypothetical protein -
MKCMC460_RS13535 (MKCMC460_26950) 2894214..2895938 - 1725 WP_236975460.1 malto-oligosyltrehalose trehalohydrolase -
MKCMC460_RS13540 (MKCMC460_26960) 2895931..2898231 - 2301 WP_236975451.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14586.65 Da        Isoelectric Point: 6.0774

>T40363 WP_236975464.1 NZ_AP025524:2892966-2893370 [Mycobacterium sp. 20KCMC460]
VILIDTSAWVEYFRASGSAAAHEVRRLISDHADQLAMCEPVAMEILCGATDDNAQAKLERLVNGLPSLPVDNAIDFRAAA
EVYRSARRVGATIRSITDCLIAAVAIRHGATVMHRDADFDVIARITRLDAQSLR

Download         Length: 405 bp

>T40363 NZ_AP025524:2892966-2893370 [Mycobacterium sp. 20KCMC460]
GTGATCCTCATCGACACCTCCGCGTGGGTCGAGTACTTTCGGGCCAGCGGATCAGCCGCTGCTCACGAGGTGCGCCGGCT
GATCTCTGACCACGCCGACCAGCTCGCGATGTGCGAGCCGGTGGCTATGGAAATCCTTTGCGGCGCAACCGATGACAACG
CACAGGCAAAACTCGAGCGGTTGGTCAACGGCCTACCCTCACTGCCCGTCGACAACGCCATCGATTTCCGAGCCGCGGCG
GAGGTCTATCGCTCCGCCCGGCGAGTCGGCGCAACGATTCGCAGCATCACCGACTGCCTGATCGCCGCGGTGGCTATCCG
CCATGGCGCTACGGTAATGCACCGCGACGCGGACTTCGACGTCATCGCACGCATCACCCGCCTCGACGCGCAATCGCTGC
GCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 8081.14 Da        Isoelectric Point: 4.4746

>AT40363 WP_236975466.1 NZ_AP025524:2892757-2892969 [Mycobacterium sp. 20KCMC460]
MSRTNIDIDDELAAEVMRRFGLRTKRAAVDLALRRLVGSPLNREFLLELEGVGWEGDLDDLRDDRPDQLR

Download         Length: 213 bp

>AT40363 NZ_AP025524:2892757-2892969 [Mycobacterium sp. 20KCMC460]
ATGTCGCGCACCAATATCGACATCGACGACGAACTCGCCGCCGAGGTGATGCGTCGGTTCGGCCTGCGCACCAAGAGGGC
CGCCGTCGATCTCGCGCTGCGTCGACTGGTGGGTTCGCCGTTGAATCGCGAGTTCCTGCTCGAGCTCGAAGGTGTCGGCT
GGGAAGGCGACCTCGACGATCTCCGCGACGATCGGCCAGACCAGCTCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References