Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2431534..2432168 Replicon chromosome
Accession NZ_AP025524
Organism Mycobacterium sp. 20KCMC460

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MKCMC460_RS11400 Protein ID WP_236976442.1
Coordinates 2431767..2432168 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MKCMC460_RS11395 Protein ID WP_236976443.1
Coordinates 2431534..2431770 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKCMC460_RS11375 (MKCMC460_22680) 2427494..2428585 + 1092 WP_238305731.1 restriction endonuclease subunit S -
MKCMC460_RS11380 (MKCMC460_22690) 2428598..2430136 + 1539 WP_236976445.1 type I restriction-modification system subunit M -
MKCMC460_RS11385 2430376..2430615 + 240 Protein_2260 glycosyltransferase -
MKCMC460_RS11390 (MKCMC460_22700) 2430670..2431431 + 762 WP_236976444.1 FAD-dependent thymidylate synthase -
MKCMC460_RS11395 (MKCMC460_22710) 2431534..2431770 + 237 WP_236976443.1 BrnA antitoxin family protein Antitoxin
MKCMC460_RS11400 (MKCMC460_22720) 2431767..2432168 + 402 WP_236976442.1 type II toxin-antitoxin system VapC family toxin Toxin
MKCMC460_RS11405 (MKCMC460_22730) 2432230..2433132 + 903 WP_236976441.1 4-hydroxy-tetrahydrodipicolinate synthase -
MKCMC460_RS11410 (MKCMC460_22750) 2433140..2434816 + 1677 WP_236976439.1 ribonuclease J -
MKCMC460_RS11415 (MKCMC460_22760) 2434813..2435685 - 873 WP_236976437.1 SAM-dependent methyltransferase -
MKCMC460_RS11420 (MKCMC460_22770) 2435690..2436511 - 822 WP_236984249.1 mycofactocin-coupled SDR family oxidoreductase -
MKCMC460_RS11425 (MKCMC460_22780) 2436508..2436822 - 315 WP_236976435.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(5-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14708.99 Da        Isoelectric Point: 8.1422

>T40362 WP_236976442.1 NZ_AP025524:2431767-2432168 [Mycobacterium sp. 20KCMC460]
VKDFVIDASALVLSLVGKTAAADALRQRLPQMRRHAPHLIDAEVGNVLRRHERAGLISAREAETALRMLDALVDNRYPHA
GMLARRAWEMRHHVSFYDELYAALAGHLDIPLLTADARLDRAAGLACRVEVVG

Download         Length: 402 bp

>T40362 NZ_AP025524:2431767-2432168 [Mycobacterium sp. 20KCMC460]
GTGAAGGACTTTGTCATCGATGCGTCGGCATTAGTGCTGAGCCTGGTCGGTAAGACCGCCGCAGCGGACGCGTTGCGGCA
GCGGCTGCCTCAGATGCGCCGACATGCGCCGCACCTGATCGACGCGGAGGTGGGAAATGTGCTGCGCCGTCACGAGCGGG
CCGGGCTCATAAGCGCCAGAGAAGCTGAAACGGCGCTGCGGATGCTCGATGCACTGGTAGACAACCGCTACCCACATGCC
GGGATGTTGGCTCGCCGAGCGTGGGAAATGCGGCACCACGTCAGCTTCTACGACGAGCTTTATGCAGCCCTTGCCGGACA
TCTTGACATCCCGCTACTCACTGCGGATGCCCGCCTCGATCGCGCGGCAGGCCTGGCATGTCGCGTCGAAGTGGTCGGAT
GA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8643.72 Da        Isoelectric Point: 4.7719

>AT40362 WP_236976443.1 NZ_AP025524:2431534-2431770 [Mycobacterium sp. 20KCMC460]
VATIQIREIPEDAYLVIRNRARAAGRSLQSYMRDWVVDFANRPTPAEALEEMAAARKAGDTPAATTESILADLAEDRR

Download         Length: 237 bp

>AT40362 NZ_AP025524:2431534-2431770 [Mycobacterium sp. 20KCMC460]
GTGGCGACCATACAGATCCGGGAAATCCCCGAGGATGCCTACCTGGTCATCCGAAATCGTGCCCGCGCCGCGGGGCGATC
GCTGCAGTCGTACATGCGCGACTGGGTGGTCGATTTCGCCAACCGCCCCACTCCGGCTGAGGCGCTGGAAGAAATGGCGG
CGGCACGGAAGGCGGGCGATACTCCGGCCGCCACAACGGAATCCATCCTCGCCGATTTGGCCGAAGACCGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References