Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-VapB
Location 2133354..2134035 Replicon chromosome
Accession NZ_AP025524
Organism Mycobacterium sp. 20KCMC460

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MKCMC460_RS09985 Protein ID WP_236981739.1
Coordinates 2133354..2133782 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MKCMC460_RS09990 Protein ID WP_236981740.1
Coordinates 2133769..2134035 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKCMC460_RS09960 (MKCMC460_19900) 2128572..2129651 + 1080 WP_238305648.1 tRNA 2-thiouridine(34) synthase MnmA -
MKCMC460_RS09965 (MKCMC460_19910) 2129658..2130722 - 1065 WP_236981735.1 PE family protein -
MKCMC460_RS09970 (MKCMC460_19920) 2130996..2131595 + 600 WP_236981736.1 class I SAM-dependent methyltransferase -
MKCMC460_RS09975 (MKCMC460_19930) 2131612..2132226 - 615 WP_236981737.1 sensor domain-containing protein -
MKCMC460_RS09980 (MKCMC460_19940) 2132320..2133333 + 1014 WP_236981738.1 methionine synthase -
MKCMC460_RS09985 (MKCMC460_19950) 2133354..2133782 - 429 WP_236981739.1 type II toxin-antitoxin system VapC family toxin Toxin
MKCMC460_RS09990 (MKCMC460_19960) 2133769..2134035 - 267 WP_236981740.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MKCMC460_RS09995 (MKCMC460_19970) 2134132..2136219 + 2088 WP_238305650.1 NAD-dependent DNA ligase LigA -
MKCMC460_RS10000 (MKCMC460_19980) 2136289..2136897 + 609 WP_236981741.1 TetR/AcrR family transcriptional regulator -
MKCMC460_RS10005 (MKCMC460_19990) 2137036..2137482 + 447 WP_255731150.1 MmpS family transport accessory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-133)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(7-47)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15646.82 Da        Isoelectric Point: 6.8530

>T40361 WP_236981739.1 NZ_AP025524:c2133782-2133354 [Mycobacterium sp. 20KCMC460]
MLLLDVNVCLYAIREDSIEHSRYRGSLEDLLNGDEPVGISELVLSGVMRLITNHRIFRQPSSTGQALEACGRLRSAPSAV
VLRPGPRHWDIFDALCAATGARGNTIADAYHAALAIENGATWVTTDRGFARFPGLRWRLPFD

Download         Length: 429 bp

>T40361 NZ_AP025524:c2133782-2133354 [Mycobacterium sp. 20KCMC460]
ATGCTGCTCCTTGACGTCAACGTCTGCCTCTACGCGATCCGCGAAGACAGCATCGAGCACTCTCGCTACCGCGGGTCGCT
GGAAGATCTGTTGAACGGCGACGAACCGGTGGGGATCAGCGAGCTGGTGCTGTCGGGAGTCATGCGGTTGATCACCAACC
ATCGAATATTTCGGCAGCCCAGTTCCACCGGACAGGCGCTTGAGGCGTGCGGACGGCTGCGGTCCGCGCCGTCCGCCGTG
GTGCTGCGACCGGGGCCGCGGCATTGGGACATCTTCGATGCCCTCTGCGCCGCGACCGGGGCGAGAGGCAACACGATCGC
CGATGCCTACCACGCCGCGTTGGCGATCGAGAACGGCGCAACCTGGGTTACCACCGACCGCGGTTTCGCCCGCTTTCCGG
GCCTTCGCTGGCGCCTTCCATTCGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9415.72 Da        Isoelectric Point: 5.0008

>AT40361 WP_236981740.1 NZ_AP025524:c2134035-2133769 [Mycobacterium sp. 20KCMC460]
MMLWCTMRTTVNIDDSLLAEAKVLAARTSRSLSAVVEDALRAMLRRDTDTSQRAAFQLATHGTGGLRPGVSLEDKDALAD
ILGDNAAP

Download         Length: 267 bp

>AT40361 NZ_AP025524:c2134035-2133769 [Mycobacterium sp. 20KCMC460]
ATGATGTTATGGTGCACCATGCGGACGACGGTCAATATCGACGACAGCCTGCTGGCCGAGGCAAAGGTGTTGGCCGCCCG
AACGTCGCGATCCCTGAGCGCCGTGGTGGAGGATGCGTTGCGCGCGATGCTGCGCCGTGACACGGACACATCGCAGCGCG
CAGCATTTCAGCTGGCGACCCATGGAACCGGCGGCTTGCGTCCCGGCGTCAGCCTCGAGGACAAGGACGCCCTCGCCGAC
ATCCTCGGTGACAATGCTGCTCCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References