Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 1492678..1493312 Replicon chromosome
Accession NZ_AP025524
Organism Mycobacterium sp. 20KCMC460

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MKCMC460_RS06960 Protein ID WP_236981251.1
Coordinates 1492678..1493070 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MKCMC460_RS06965 Protein ID WP_236981252.1
Coordinates 1493067..1493312 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKCMC460_RS06935 (MKCMC460_13650) 1487858..1488433 + 576 WP_236981248.1 ECF RNA polymerase sigma factor SigD -
MKCMC460_RS06940 (MKCMC460_13660) 1488426..1489346 + 921 WP_236981249.1 anti-sigma-D factor RsdA -
MKCMC460_RS06945 (MKCMC460_13670) 1489363..1489776 - 414 WP_236981250.1 DUF5319 domain-containing protein -
MKCMC460_RS06950 (MKCMC460_13680) 1489941..1491530 + 1590 WP_238305441.1 IMP dehydrogenase -
MKCMC460_RS06955 (MKCMC460_13690) 1491545..1492672 + 1128 WP_236983847.1 GuaB3 family IMP dehydrogenase-related protein -
MKCMC460_RS06960 (MKCMC460_13700) 1492678..1493070 - 393 WP_236981251.1 type II toxin-antitoxin system VapC family toxin Toxin
MKCMC460_RS06965 (MKCMC460_13710) 1493067..1493312 - 246 WP_236981252.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MKCMC460_RS06970 (MKCMC460_13720) 1493385..1495130 + 1746 WP_236981253.1 GMC family oxidoreductase -
MKCMC460_RS06975 (MKCMC460_13730) 1495358..1496047 - 690 WP_236981254.1 TetR/AcrR family transcriptional regulator -
MKCMC460_RS06980 (MKCMC460_13740) 1496075..1497175 + 1101 WP_236981255.1 hypothetical protein -
MKCMC460_RS06985 (MKCMC460_13750) 1497214..1498068 + 855 WP_238305443.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-46)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14488.61 Da        Isoelectric Point: 6.9897

>T40359 WP_236981251.1 NZ_AP025524:c1493070-1492678 [Mycobacterium sp. 20KCMC460]
VKRLLVDTHVWLWMQSDPGRLRDEARGLVADARNDVFLSAASAWEIAIKYRLGKLLLPETPATYVPDRMRRSGTSALPVE
HAHTLRTAALPDHHRDPFDRLIVAQAQLLNLTVVTADEQLSAYDVALVAA

Download         Length: 393 bp

>T40359 NZ_AP025524:c1493070-1492678 [Mycobacterium sp. 20KCMC460]
GTGAAGCGTTTGCTGGTAGACACTCACGTCTGGCTGTGGATGCAGTCTGATCCCGGGCGGCTACGCGATGAAGCACGTGG
CCTCGTTGCGGACGCCCGCAACGACGTTTTCCTCTCCGCCGCCAGCGCCTGGGAGATCGCGATCAAATACCGCCTCGGCA
AACTCCTGTTGCCCGAAACCCCAGCCACGTACGTACCGGATCGAATGCGTCGTTCCGGAACATCTGCGCTACCGGTCGAA
CACGCTCACACGCTGCGCACCGCCGCGCTTCCAGACCATCACCGGGATCCGTTCGACCGCCTCATCGTCGCCCAGGCGCA
GCTACTCAACCTGACCGTCGTGACCGCCGATGAGCAACTGTCCGCCTACGACGTCGCGCTCGTCGCGGCGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9151.48 Da        Isoelectric Point: 6.2191

>AT40359 WP_236981252.1 NZ_AP025524:c1493312-1493067 [Mycobacterium sp. 20KCMC460]
MTKSTVLRVGVHEAKTRMSELLRLVDSGQEIEIARSGEPVAKLVPFRPREIRRLGIDHGIYTVPDDFDAPLPDDVLQSFH
Q

Download         Length: 246 bp

>AT40359 NZ_AP025524:c1493312-1493067 [Mycobacterium sp. 20KCMC460]
ATGACTAAGTCCACTGTGCTACGGGTCGGCGTCCACGAGGCGAAGACACGCATGTCGGAGCTGTTGCGACTGGTCGATAG
CGGGCAGGAGATCGAGATTGCGCGCAGTGGCGAACCCGTGGCAAAGCTGGTGCCATTTCGCCCGCGCGAGATCCGGCGCT
TGGGCATTGACCACGGCATATACACCGTGCCTGATGATTTCGACGCTCCGTTGCCAGACGATGTGCTGCAAAGCTTCCAT
CAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References