Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-PHD
Location 87913..88592 Replicon chromosome
Accession NZ_AP025524
Organism Mycobacterium sp. 20KCMC460

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MKCMC460_RS00440 Protein ID WP_236978924.1
Coordinates 88188..88592 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MKCMC460_RS00435 Protein ID WP_236978923.1
Coordinates 87913..88191 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKCMC460_RS00415 (MKCMC460_00800) 83703..84611 - 909 WP_255731129.1 CoA ester lyase -
MKCMC460_RS00420 (MKCMC460_00810) 84625..85809 - 1185 WP_236978917.1 CoA transferase -
MKCMC460_RS00425 (MKCMC460_00820) 85802..87148 - 1347 WP_236978919.1 LLM class flavin-dependent oxidoreductase -
MKCMC460_RS00430 (MKCMC460_00830) 87218..87862 + 645 WP_236978921.1 GntR family transcriptional regulator -
MKCMC460_RS00435 (MKCMC460_00840) 87913..88191 + 279 WP_236978923.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MKCMC460_RS00440 (MKCMC460_00850) 88188..88592 + 405 WP_236978924.1 type II toxin-antitoxin system VapC family toxin Toxin
MKCMC460_RS00445 (MKCMC460_00860) 88993..89889 + 897 WP_236978926.1 helix-turn-helix transcriptional regulator -
MKCMC460_RS00450 (MKCMC460_00870) 89956..90540 - 585 WP_238305173.1 TetR/AcrR family transcriptional regulator -
MKCMC460_RS00455 (MKCMC460_00880) 90608..91768 + 1161 WP_236978932.1 LLM class flavin-dependent oxidoreductase -
MKCMC460_RS00460 (MKCMC460_00890) 91790..93223 - 1434 WP_238305175.1 PE-PGRS family protein -
MKCMC460_RS00465 93209..93520 - 312 Protein_90 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-118)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-64)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14417.58 Da        Isoelectric Point: 6.4792

>T40358 WP_236978924.1 NZ_AP025524:88188-88592 [Mycobacterium sp. 20KCMC460]
VIYLDTSALTKLLIAEAETAALRAWLNAQHERGEHAATSTLGRIELMRAVYRYAATEYVGRARYLLDGLDMVTLSAPVLT
AAETIGPPTLRSLDAIHLAAAAQLKQELTAFVTYDRRLLAGCHDVGIPAISPGS

Download         Length: 405 bp

>T40358 NZ_AP025524:88188-88592 [Mycobacterium sp. 20KCMC460]
GTGATCTACCTGGACACCTCGGCCCTGACGAAACTGCTCATCGCCGAGGCTGAGACGGCTGCACTGCGAGCGTGGCTCAA
CGCCCAGCACGAGCGGGGCGAGCACGCAGCGACCAGCACGCTGGGCCGCATCGAGTTGATGCGAGCCGTTTACAGGTACG
CAGCGACTGAGTACGTCGGGCGGGCCCGCTATCTGCTGGACGGCCTTGACATGGTCACGCTCAGCGCACCTGTGTTGACC
GCAGCGGAGACCATCGGTCCGCCTACGCTGCGTTCGCTCGACGCGATCCACCTGGCGGCTGCTGCGCAACTCAAGCAGGA
GCTGACGGCTTTCGTCACTTACGACCGGCGTTTGTTGGCGGGCTGCCACGACGTCGGGATTCCGGCGATATCGCCCGGCT
CATGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10102.44 Da        Isoelectric Point: 5.7202

>AT40358 WP_236978923.1 NZ_AP025524:87913-88191 [Mycobacterium sp. 20KCMC460]
MEVIGVRELRQHASRYLARVEAGEELGVANHGRLVARLVPVAQATRSRTALIDAGLLLPARSPENLYDPAGTSPPSEKRT
LSDVLEEMRDEQ

Download         Length: 279 bp

>AT40358 NZ_AP025524:87913-88191 [Mycobacterium sp. 20KCMC460]
ATGGAGGTCATCGGGGTCCGTGAACTGCGACAACATGCATCGCGGTACCTCGCGCGGGTCGAGGCCGGCGAGGAGCTGGG
CGTTGCCAATCACGGGCGCCTGGTTGCCCGCCTCGTACCGGTTGCGCAAGCGACGCGGTCCCGCACCGCCCTGATAGATG
CGGGACTGCTACTCCCGGCCCGCAGCCCGGAAAATCTGTACGACCCCGCCGGCACATCGCCGCCGAGCGAAAAGCGCACA
CTGTCGGACGTTCTCGAAGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References