Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 1455018..1455658 | Replicon | chromosome |
| Accession | NZ_AP025519 | ||
| Organism | Pasteurella multocida strain Pm1 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | V4NDJ2 |
| Locus tag | MFE95_RS07430 | Protein ID | WP_016533221.1 |
| Coordinates | 1455482..1455658 (-) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | V4Q272 |
| Locus tag | MFE95_RS07425 | Protein ID | WP_016533220.1 |
| Coordinates | 1455018..1455434 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MFE95_RS07375 (PASm1_14440) | 1450419..1450955 | + | 537 | WP_014391470.1 | phage N-6-adenine-methyltransferase | - |
| MFE95_RS07380 (PASm1_14450) | 1450945..1451403 | + | 459 | WP_016569985.1 | recombination protein NinB | - |
| MFE95_RS07385 (PASm1_14460) | 1451477..1451689 | + | 213 | WP_016533468.1 | hypothetical protein | - |
| MFE95_RS07390 (PASm1_14470) | 1451777..1452379 | + | 603 | WP_016533469.1 | recombination protein NinG | - |
| MFE95_RS07395 (PASm1_14480) | 1452379..1452744 | + | 366 | WP_016533470.1 | antiterminator Q family protein | - |
| MFE95_RS07400 (PASm1_14490) | 1452953..1453168 | - | 216 | WP_015691066.1 | hypothetical protein | - |
| MFE95_RS07405 (PASm1_14500) | 1453546..1453911 | + | 366 | WP_016533461.1 | phage holin, lambda family | - |
| MFE95_RS07410 (PASm1_14510) | 1453883..1454467 | + | 585 | WP_016533462.1 | glycoside hydrolase family 19 protein | - |
| MFE95_RS07415 (PASm1_14520) | 1454470..1454793 | + | 324 | WP_016569983.1 | DUF2570 family protein | - |
| MFE95_RS07420 (PASm1_14530) | 1454771..1454980 | + | 210 | WP_238300230.1 | hypothetical protein | - |
| MFE95_RS07425 (PASm1_14540) | 1455018..1455434 | - | 417 | WP_016533220.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MFE95_RS07430 (PASm1_14550) | 1455482..1455658 | - | 177 | WP_016533221.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MFE95_RS07435 (PASm1_14560) | 1455917..1456393 | + | 477 | WP_075269225.1 | DUF1441 family protein | - |
| MFE95_RS07440 (PASm1_14570) | 1456396..1458504 | + | 2109 | WP_238300231.1 | phage terminase large subunit family protein | - |
| MFE95_RS07445 (PASm1_14580) | 1458501..1458722 | + | 222 | WP_014391481.1 | hypothetical protein | - |
| MFE95_RS07450 (PASm1_14590) | 1458719..1460257 | + | 1539 | WP_238300232.1 | phage portal protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1429223..1501620 | 72397 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6530.60 Da Isoelectric Point: 10.7333
>T40356 WP_016533221.1 NZ_AP025519:c1455658-1455482 [Pasteurella multocida]
MKQSEFLRWLKAQGVETKEGSNHIKLYLNGNQSALPRHPSKEIAKGTEIAVKKQLGLK
MKQSEFLRWLKAQGVETKEGSNHIKLYLNGNQSALPRHPSKEIAKGTEIAVKKQLGLK
Download Length: 177 bp
>T40356 NZ_AP025519:c1455658-1455482 [Pasteurella multocida]
ATGAAACAAAGTGAGTTTTTAAGATGGCTGAAAGCTCAAGGGGTAGAAACTAAAGAAGGCTCAAACCACATTAAGCTCTA
CCTAAACGGCAACCAATCAGCTCTCCCAAGACATCCAAGCAAAGAGATAGCCAAGGGAACTGAAATAGCAGTTAAAAAGC
AATTAGGTCTAAAATAA
ATGAAACAAAGTGAGTTTTTAAGATGGCTGAAAGCTCAAGGGGTAGAAACTAAAGAAGGCTCAAACCACATTAAGCTCTA
CCTAAACGGCAACCAATCAGCTCTCCCAAGACATCCAAGCAAAGAGATAGCCAAGGGAACTGAAATAGCAGTTAAAAAGC
AATTAGGTCTAAAATAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15580.82 Da Isoelectric Point: 4.3715
>AT40356 WP_016533220.1 NZ_AP025519:c1455434-1455018 [Pasteurella multocida]
MLYPAKFDKEDNGLYAVSFRDIPEALTCGDNFDDAVAMAKDALVTSMDFYFEDFRKVPLPTEPEQDEVLIELPDSVFAKV
LLLNEMVEQNISNAELARRINVRPQEMQRITNISHSTKIDTISRALSALGKKLQLSVV
MLYPAKFDKEDNGLYAVSFRDIPEALTCGDNFDDAVAMAKDALVTSMDFYFEDFRKVPLPTEPEQDEVLIELPDSVFAKV
LLLNEMVEQNISNAELARRINVRPQEMQRITNISHSTKIDTISRALSALGKKLQLSVV
Download Length: 417 bp
>AT40356 NZ_AP025519:c1455434-1455018 [Pasteurella multocida]
ATGTTATATCCAGCAAAATTTGATAAAGAAGATAATGGGCTTTATGCTGTATCATTTCGTGATATACCTGAAGCCTTAAC
TTGTGGTGATAACTTCGACGATGCCGTCGCAATGGCAAAAGATGCCTTGGTTACATCAATGGATTTTTACTTTGAGGACT
TCCGCAAAGTGCCATTACCAACCGAGCCAGAGCAAGATGAGGTATTAATCGAGTTACCAGATAGTGTTTTTGCTAAAGTG
CTTTTATTAAATGAGATGGTTGAACAAAATATCTCTAATGCTGAATTAGCAAGAAGAATTAATGTTCGACCACAGGAAAT
GCAACGCATTACTAATATCTCGCATAGCACAAAAATCGACACAATAAGCCGTGCTTTGTCAGCACTCGGTAAAAAACTAC
AACTTTCAGTCGTCTAA
ATGTTATATCCAGCAAAATTTGATAAAGAAGATAATGGGCTTTATGCTGTATCATTTCGTGATATACCTGAAGCCTTAAC
TTGTGGTGATAACTTCGACGATGCCGTCGCAATGGCAAAAGATGCCTTGGTTACATCAATGGATTTTTACTTTGAGGACT
TCCGCAAAGTGCCATTACCAACCGAGCCAGAGCAAGATGAGGTATTAATCGAGTTACCAGATAGTGTTTTTGCTAAAGTG
CTTTTATTAAATGAGATGGTTGAACAAAATATCTCTAATGCTGAATTAGCAAGAAGAATTAATGTTCGACCACAGGAAAT
GCAACGCATTACTAATATCTCGCATAGCACAAAAATCGACACAATAAGCCGTGCTTTGTCAGCACTCGGTAAAAAACTAC
AACTTTCAGTCGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|