Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 1237963..1238603 | Replicon | chromosome |
| Accession | NZ_AP025519 | ||
| Organism | Pasteurella multocida strain Pm1 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | V4NDJ2 |
| Locus tag | MFE95_RS06125 | Protein ID | WP_016533221.1 |
| Coordinates | 1237963..1238139 (+) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | V4Q272 |
| Locus tag | MFE95_RS06130 | Protein ID | WP_016533220.1 |
| Coordinates | 1238187..1238603 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MFE95_RS06105 (PASm1_11880) | 1233364..1234902 | - | 1539 | WP_238300232.1 | phage portal protein | - |
| MFE95_RS06110 (PASm1_11890) | 1234899..1235120 | - | 222 | WP_014391481.1 | hypothetical protein | - |
| MFE95_RS06115 (PASm1_11900) | 1235117..1237225 | - | 2109 | WP_238300231.1 | phage terminase large subunit family protein | - |
| MFE95_RS06120 (PASm1_11910) | 1237228..1237704 | - | 477 | WP_075269225.1 | DUF1441 family protein | - |
| MFE95_RS06125 (PASm1_11920) | 1237963..1238139 | + | 177 | WP_016533221.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MFE95_RS06130 (PASm1_11930) | 1238187..1238603 | + | 417 | WP_016533220.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MFE95_RS06135 (PASm1_11940) | 1238641..1238850 | - | 210 | WP_238300230.1 | hypothetical protein | - |
| MFE95_RS06140 (PASm1_11950) | 1238828..1239151 | - | 324 | WP_016569983.1 | DUF2570 family protein | - |
| MFE95_RS06145 (PASm1_11960) | 1239154..1239738 | - | 585 | WP_016533462.1 | glycoside hydrolase family 19 protein | - |
| MFE95_RS06150 (PASm1_11970) | 1239710..1240075 | - | 366 | WP_016533461.1 | phage holin, lambda family | - |
| MFE95_RS06155 (PASm1_11980) | 1240453..1240668 | + | 216 | WP_015691066.1 | hypothetical protein | - |
| MFE95_RS06160 (PASm1_11990) | 1240877..1241242 | - | 366 | WP_016533470.1 | antiterminator Q family protein | - |
| MFE95_RS06165 (PASm1_12000) | 1241242..1241844 | - | 603 | WP_016533469.1 | recombination protein NinG | - |
| MFE95_RS06170 (PASm1_12010) | 1241932..1242144 | - | 213 | WP_016533468.1 | hypothetical protein | - |
| MFE95_RS06175 (PASm1_12020) | 1242218..1242676 | - | 459 | WP_016569985.1 | recombination protein NinB | - |
| MFE95_RS06180 (PASm1_12030) | 1242666..1243202 | - | 537 | WP_014391470.1 | phage N-6-adenine-methyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1217634..1260388 | 42754 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6530.60 Da Isoelectric Point: 10.7333
>T40355 WP_016533221.1 NZ_AP025519:1237963-1238139 [Pasteurella multocida]
MKQSEFLRWLKAQGVETKEGSNHIKLYLNGNQSALPRHPSKEIAKGTEIAVKKQLGLK
MKQSEFLRWLKAQGVETKEGSNHIKLYLNGNQSALPRHPSKEIAKGTEIAVKKQLGLK
Download Length: 177 bp
>T40355 NZ_AP025519:1237963-1238139 [Pasteurella multocida]
ATGAAACAAAGTGAGTTTTTAAGATGGCTGAAAGCTCAAGGGGTAGAAACTAAAGAAGGCTCAAACCACATTAAGCTCTA
CCTAAACGGCAACCAATCAGCTCTCCCAAGACATCCAAGCAAAGAGATAGCCAAGGGAACTGAAATAGCAGTTAAAAAGC
AATTAGGTCTAAAATAA
ATGAAACAAAGTGAGTTTTTAAGATGGCTGAAAGCTCAAGGGGTAGAAACTAAAGAAGGCTCAAACCACATTAAGCTCTA
CCTAAACGGCAACCAATCAGCTCTCCCAAGACATCCAAGCAAAGAGATAGCCAAGGGAACTGAAATAGCAGTTAAAAAGC
AATTAGGTCTAAAATAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15580.82 Da Isoelectric Point: 4.3715
>AT40355 WP_016533220.1 NZ_AP025519:1238187-1238603 [Pasteurella multocida]
MLYPAKFDKEDNGLYAVSFRDIPEALTCGDNFDDAVAMAKDALVTSMDFYFEDFRKVPLPTEPEQDEVLIELPDSVFAKV
LLLNEMVEQNISNAELARRINVRPQEMQRITNISHSTKIDTISRALSALGKKLQLSVV
MLYPAKFDKEDNGLYAVSFRDIPEALTCGDNFDDAVAMAKDALVTSMDFYFEDFRKVPLPTEPEQDEVLIELPDSVFAKV
LLLNEMVEQNISNAELARRINVRPQEMQRITNISHSTKIDTISRALSALGKKLQLSVV
Download Length: 417 bp
>AT40355 NZ_AP025519:1238187-1238603 [Pasteurella multocida]
ATGTTATATCCAGCAAAATTTGATAAAGAAGATAATGGGCTTTATGCTGTATCATTTCGTGATATACCTGAAGCCTTAAC
TTGTGGTGATAACTTCGACGATGCCGTCGCAATGGCAAAAGATGCCTTGGTTACATCAATGGATTTTTACTTTGAGGACT
TCCGCAAAGTGCCATTACCAACCGAGCCAGAGCAAGATGAGGTATTAATCGAGTTACCAGATAGTGTTTTTGCTAAAGTG
CTTTTATTAAATGAGATGGTTGAACAAAATATCTCTAATGCTGAATTAGCAAGAAGAATTAATGTTCGACCACAGGAAAT
GCAACGCATTACTAATATCTCGCATAGCACAAAAATCGACACAATAAGCCGTGCTTTGTCAGCACTCGGTAAAAAACTAC
AACTTTCAGTCGTCTAA
ATGTTATATCCAGCAAAATTTGATAAAGAAGATAATGGGCTTTATGCTGTATCATTTCGTGATATACCTGAAGCCTTAAC
TTGTGGTGATAACTTCGACGATGCCGTCGCAATGGCAAAAGATGCCTTGGTTACATCAATGGATTTTTACTTTGAGGACT
TCCGCAAAGTGCCATTACCAACCGAGCCAGAGCAAGATGAGGTATTAATCGAGTTACCAGATAGTGTTTTTGCTAAAGTG
CTTTTATTAAATGAGATGGTTGAACAAAATATCTCTAATGCTGAATTAGCAAGAAGAATTAATGTTCGACCACAGGAAAT
GCAACGCATTACTAATATCTCGCATAGCACAAAAATCGACACAATAAGCCGTGCTTTGTCAGCACTCGGTAAAAAACTAC
AACTTTCAGTCGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|