Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-ParD |
| Location | 3297264..3298269 | Replicon | chromosome |
| Accession | NZ_AP025518 | ||
| Organism | Mycolicibacterium fortuitum subsp. fortuitum strain JCM 6387 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | K0VF36 |
| Locus tag | MFTT_RS15905 | Protein ID | WP_003884794.1 |
| Coordinates | 3297691..3298269 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | K0VQA4 |
| Locus tag | MFTT_RS15900 | Protein ID | WP_003884795.1 |
| Coordinates | 3297264..3297653 (+) | Length | 130 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MFTT_RS15880 (MFTT_31710) | 3293273..3293821 | - | 549 | WP_003884799.1 | GNAT family N-acetyltransferase | - |
| MFTT_RS15885 (MFTT_31720) | 3293853..3294263 | - | 411 | WP_003884798.1 | transglycosylase family protein | - |
| MFTT_RS15890 (MFTT_31730) | 3294658..3296016 | - | 1359 | WP_003884797.1 | alpha/beta hydrolase-fold protein | - |
| MFTT_RS15895 (MFTT_31740) | 3296180..3297202 | + | 1023 | WP_003884796.1 | TIGR03617 family F420-dependent LLM class oxidoreductase | - |
| MFTT_RS15900 (MFTT_31750) | 3297264..3297653 | + | 390 | WP_003884795.1 | hypothetical protein | Antitoxin |
| MFTT_RS15905 (MFTT_31760) | 3297691..3298269 | + | 579 | WP_003884794.1 | zeta toxin family protein | Toxin |
| MFTT_RS15910 (MFTT_31770) | 3298341..3298724 | + | 384 | WP_144402881.1 | hypothetical protein | - |
| MFTT_RS15915 (MFTT_31780) | 3298744..3299379 | - | 636 | WP_003884793.1 | histidine phosphatase family protein | - |
| MFTT_RS15920 (MFTT_31790) | 3299415..3299771 | - | 357 | WP_003884792.1 | hypothetical protein | - |
| MFTT_RS15925 (MFTT_31800) | 3299782..3300507 | - | 726 | WP_003884791.1 | thiocyanate hydrolase subunit gamma | - |
| MFTT_RS15930 (MFTT_31810) | 3300542..3301366 | - | 825 | WP_003884790.1 | nitrile hydratase subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21036.14 Da Isoelectric Point: 8.5146
>T40353 WP_003884794.1 NZ_AP025518:3297691-3298269 [Mycolicibacterium fortuitum subsp. fortuitum]
VKRLDLVVGCNGAGKSTFVELTLSPLLPGSPFVNADEIAKHRWPQDPASHSYEAALVAAETRAKLIQLGESFIAETVFSH
PSKLELIDDARAAGYTLILHCLLIPEELAVQRVRHRVRAGGHHVPEKKIRERYQRLWDLVAIAAIRVDSATFYDNSAVSG
PRIVAQIVGGFVVGSPTWPTWTPTALSSRWPG
VKRLDLVVGCNGAGKSTFVELTLSPLLPGSPFVNADEIAKHRWPQDPASHSYEAALVAAETRAKLIQLGESFIAETVFSH
PSKLELIDDARAAGYTLILHCLLIPEELAVQRVRHRVRAGGHHVPEKKIRERYQRLWDLVAIAAIRVDSATFYDNSAVSG
PRIVAQIVGGFVVGSPTWPTWTPTALSSRWPG
Download Length: 579 bp
>T40353 NZ_AP025518:3297691-3298269 [Mycolicibacterium fortuitum subsp. fortuitum]
GTGAAGCGTCTCGATCTCGTCGTCGGGTGCAACGGCGCCGGCAAGTCCACCTTCGTCGAGCTCACCCTCTCTCCACTGCT
CCCTGGCAGCCCGTTCGTCAACGCGGATGAAATCGCCAAACATCGCTGGCCGCAAGACCCCGCGTCCCACTCGTACGAAG
CCGCGCTCGTGGCCGCAGAAACCCGTGCCAAACTCATTCAGCTCGGCGAATCCTTCATCGCCGAGACCGTGTTTTCGCAC
CCCTCCAAACTCGAGCTCATCGACGACGCACGGGCCGCTGGATACACCCTGATCCTGCACTGCCTCCTGATCCCCGAAGA
GCTGGCCGTACAGCGAGTGCGCCACCGCGTTCGAGCCGGCGGGCATCACGTGCCCGAGAAGAAGATTCGGGAACGCTACC
AACGGCTTTGGGACCTCGTCGCAATCGCGGCGATCCGGGTCGACTCGGCAACGTTCTACGACAACAGCGCCGTTTCAGGC
CCGCGGATCGTCGCCCAGATCGTCGGCGGGTTCGTCGTGGGATCGCCTACCTGGCCGACATGGACGCCAACAGCACTGAG
TTCCCGCTGGCCTGGATAA
GTGAAGCGTCTCGATCTCGTCGTCGGGTGCAACGGCGCCGGCAAGTCCACCTTCGTCGAGCTCACCCTCTCTCCACTGCT
CCCTGGCAGCCCGTTCGTCAACGCGGATGAAATCGCCAAACATCGCTGGCCGCAAGACCCCGCGTCCCACTCGTACGAAG
CCGCGCTCGTGGCCGCAGAAACCCGTGCCAAACTCATTCAGCTCGGCGAATCCTTCATCGCCGAGACCGTGTTTTCGCAC
CCCTCCAAACTCGAGCTCATCGACGACGCACGGGCCGCTGGATACACCCTGATCCTGCACTGCCTCCTGATCCCCGAAGA
GCTGGCCGTACAGCGAGTGCGCCACCGCGTTCGAGCCGGCGGGCATCACGTGCCCGAGAAGAAGATTCGGGAACGCTACC
AACGGCTTTGGGACCTCGTCGCAATCGCGGCGATCCGGGTCGACTCGGCAACGTTCTACGACAACAGCGCCGTTTCAGGC
CCGCGGATCGTCGCCCAGATCGTCGGCGGGTTCGTCGTGGGATCGCCTACCTGGCCGACATGGACGCCAACAGCACTGAG
TTCCCGCTGGCCTGGATAA
Antitoxin
Download Length: 130 a.a. Molecular weight: 13567.00 Da Isoelectric Point: 4.5256
>AT40353 WP_003884795.1 NZ_AP025518:3297264-3297653 [Mycolicibacterium fortuitum subsp. fortuitum]
MTETADRVTRFAADLIDSAAAEGARQSRSAKQQLDHWARVGRAVSSRHSAARRKVEAALAGDIALGELTAEEGAVFDAEI
AASIEESLARTDYGKALAARGITTVALDEDGEIVQYLPDGSTAVLAPQQ
MTETADRVTRFAADLIDSAAAEGARQSRSAKQQLDHWARVGRAVSSRHSAARRKVEAALAGDIALGELTAEEGAVFDAEI
AASIEESLARTDYGKALAARGITTVALDEDGEIVQYLPDGSTAVLAPQQ
Download Length: 390 bp
>AT40353 NZ_AP025518:3297264-3297653 [Mycolicibacterium fortuitum subsp. fortuitum]
ATGACGGAGACCGCAGATCGTGTGACCCGGTTCGCCGCTGACCTCATCGACAGTGCTGCCGCGGAAGGTGCACGTCAGAG
CCGGTCGGCCAAGCAGCAGCTCGACCATTGGGCCCGCGTGGGCCGCGCTGTGTCCAGCCGGCACAGCGCCGCCCGCCGAA
AGGTAGAGGCCGCCCTGGCCGGCGACATTGCGCTCGGCGAATTGACCGCCGAGGAAGGCGCGGTATTCGACGCCGAGATC
GCCGCATCAATCGAGGAAAGCCTGGCCCGCACCGACTACGGCAAGGCACTGGCCGCCCGTGGTATCACCACCGTTGCGCT
GGACGAGGACGGCGAGATCGTGCAGTACCTGCCCGACGGCAGCACCGCGGTGTTGGCGCCGCAGCAGTGA
ATGACGGAGACCGCAGATCGTGTGACCCGGTTCGCCGCTGACCTCATCGACAGTGCTGCCGCGGAAGGTGCACGTCAGAG
CCGGTCGGCCAAGCAGCAGCTCGACCATTGGGCCCGCGTGGGCCGCGCTGTGTCCAGCCGGCACAGCGCCGCCCGCCGAA
AGGTAGAGGCCGCCCTGGCCGGCGACATTGCGCTCGGCGAATTGACCGCCGAGGAAGGCGCGGTATTCGACGCCGAGATC
GCCGCATCAATCGAGGAAAGCCTGGCCCGCACCGACTACGGCAAGGCACTGGCCGCCCGTGGTATCACCACCGTTGCGCT
GGACGAGGACGGCGAGATCGTGCAGTACCTGCCCGACGGCAGCACCGCGGTGTTGGCGCCGCAGCAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|