Detailed information of TA system TA040352

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 1351717..1352349
• Replicon: chromosome
• Accession: NZ_AP025518
• Organism: Mycolicibacterium fortuitum subsp. fortuitum strain JCM 6387

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: MFTT_RS06355
• Protein ID: WP_003881879.1
• Coordinates: 1351900..1352349 (+)
• Length: 150 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: K0VFT5
• Locus tag: MFTT_RS06350
• Protein ID: WP_003881878.1
• Coordinates: 1351717..1351896 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MFTT_RS06335 (MFTT_12680)	1347256..1347990	+	735	WP_003881875.1	enoyl-CoA hydratase	-
MFTT_RS06340 (MFTT_12690)	1347992..1349098	+	1107	WP_003881876.1	MBL fold metallo-hydrolase	-
MFTT_RS06345 (MFTT_12700)	1349165..1351657	+	2493	WP_003881877.1	cation-translocating P-type ATPase	-
MFTT_RS06350 (MFTT_12710)	1351717..1351896	+	180	WP_003881878.1	antitoxin	Antitoxin
MFTT_RS06355 (MFTT_12720)	1351900..1352349	+	450	WP_003881879.1	SRPBCC family protein	Toxin
MFTT_RS06360 (MFTT_12730)	1352353..1352781	-	429	WP_003881880.1	hypothetical protein	-
MFTT_RS06365 (MFTT_12740)	1352801..1353502	-	702	WP_003881881.1	hypothetical protein	-
MFTT_RS30965 (MFTT_12750)	1353499..1353630	-	132	WP_003881882.1	hypothetical protein	-
MFTT_RS06370 (MFTT_12760)	1353646..1354446	-	801	WP_003881883.1	CbbQ/NirQ/NorQ/GpvN family protein	-
MFTT_RS06375 (MFTT_12770)	1354443..1355972	-	1530	WP_003881884.1	VWA domain-containing protein	-
MFTT_RS06380 (MFTT_12780)	1356124..1356726	-	603	WP_003881886.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (1-145)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-52)

Sequences

Toxin

Protein

• Length: 150 a.a.
• Molecular weight: 16117.67 Da
• Isoelectric Point: 9.6573

>T40352 WP_003881879.1 NZ_AP025518:1351900-1352349 [Mycolicibacterium fortuitum subsp. fortuitum]
MAKLSVSVEVPLPPEKAWEYASDLSRYDEWLSIHRAWRSKLPETLEKGTVIDSIVEVKGMLNRVKWTLVNYKPPQSLTLN
GDGRGGVKVKLIGKITPAAVDGGDGAKVSFDVHLGGPALFGPIGMVVAAALKGDIQQSLNKFKELYASS

Nucleotide

• Length: 450 bp

>T40352 NZ_AP025518:1351900-1352349 [Mycolicibacterium fortuitum subsp. fortuitum]
ATGGCCAAATTGTCTGTCTCCGTCGAAGTTCCGTTGCCGCCGGAGAAGGCGTGGGAGTACGCCTCTGATCTGTCCCGGTA
CGACGAGTGGCTCAGCATCCACCGGGCCTGGCGGTCGAAGTTGCCCGAAACCCTGGAAAAGGGCACGGTGATCGACTCGA
TCGTCGAGGTCAAGGGCATGTTGAACCGCGTGAAGTGGACGCTGGTGAACTACAAGCCGCCGCAGTCGTTGACCCTCAAC
GGCGACGGTCGTGGCGGGGTGAAGGTCAAGCTGATCGGAAAGATTACGCCGGCCGCCGTTGACGGTGGAGACGGTGCGAA
GGTCTCTTTCGACGTGCATCTGGGTGGGCCCGCGCTGTTCGGGCCGATCGGCATGGTGGTCGCCGCCGCGCTCAAGGGTG
ATATCCAGCAGTCGCTGAACAAGTTCAAGGAGCTCTACGCGTCGTCGTAG

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6434.15 Da
• Isoelectric Point: 4.5045

>AT40352 WP_003881878.1 NZ_AP025518:1351717-1351896 [Mycolicibacterium fortuitum subsp. fortuitum]
MGFLDKAKDLLSQNADKVEQAIEKAGDIVDEKTQGKYSGVVDKAQEAAKNAINKEEPQQ

Nucleotide

• Length: 180 bp

>AT40352 NZ_AP025518:1351717-1351896 [Mycolicibacterium fortuitum subsp. fortuitum]
ATGGGATTCCTGGACAAGGCCAAGGACCTTCTGTCGCAGAACGCCGACAAGGTCGAGCAGGCCATCGAGAAGGCCGGCGA
CATCGTCGACGAGAAGACTCAGGGCAAGTACTCGGGCGTGGTCGACAAGGCACAGGAAGCGGCGAAGAACGCCATCAACA
AGGAAGAACCGCAGCAGTAG

Structures

Antitoxin

• AlphaFold DB: K0VFT5