Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 414872..416729 Replicon chromosome
Accession NZ_AP025517
Organism Pandoraea sp. NE5

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PanNE5_RS01905 Protein ID WP_261939125.1
Coordinates 415821..416729 (-) Length 303 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A9E9ID32
Locus tag PanNE5_RS01900 Protein ID WP_026132232.1
Coordinates 414872..415741 (-) Length 290 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PanNE5_RS01880 (PanNE5_03780) 410103..411599 - 1497 WP_017235330.1 aldehyde dehydrogenase -
PanNE5_RS01885 (PanNE5_03790) 411613..412431 - 819 WP_017235329.1 aspartate dehydrogenase -
PanNE5_RS01890 (PanNE5_03800) 412424..414076 - 1653 WP_017235328.1 thiamine pyrophosphate-binding protein -
PanNE5_RS01895 (PanNE5_03810) 414069..414875 - 807 WP_261939124.1 SDR family oxidoreductase -
PanNE5_RS01900 (PanNE5_03820) 414872..415741 - 870 WP_026132232.1 IclR family transcriptional regulator Antitoxin
PanNE5_RS01905 (PanNE5_03830) 415821..416729 - 909 WP_261939125.1 alpha/beta fold hydrolase Toxin
PanNE5_RS01910 (PanNE5_03840) 416831..417388 - 558 WP_017235324.1 cupin domain-containing protein -
PanNE5_RS01915 (PanNE5_03850) 417429..418211 - 783 WP_232424702.1 SDR family oxidoreductase -
PanNE5_RS01920 (PanNE5_03860) 418239..419021 - 783 WP_017235322.1 ABC transporter permease -
PanNE5_RS01925 (PanNE5_03870) 419061..419930 - 870 WP_017235321.1 ABC transporter ATP-binding protein -
PanNE5_RS01930 (PanNE5_03880) 420245..421321 - 1077 WP_174975102.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(53-288)

Antitoxin

Transcription regulator IclR, C-terminal

(144-267)


Sequences

Toxin        


Download         Length: 303 a.a.        Molecular weight: 31042.19 Da        Isoelectric Point: 5.3062

>T40350 WP_261939125.1 NZ_AP025517:c416729-415821 [Pandoraea sp. NE5]
MQAEAFQSEVPEDAAVAPLCARLDAFPYRTVATRAGTVGYRSAGTQAEGAMPVVMLHGIGSGAASWLAQFEATGLDTALY
AWDAPGYGQTTNVADAEPHADAYVEALAAWLDALGLARVALVGHSLGAIMATQFASRAPQRVSGLFLCSPAGGYGKADAQ
VRVSKRDGRLAMLDKLGPTGMARERSDNLVAPNAAALPRAWVKWNMARVLPAGYRQATHLLSNGDVAGALAQYVAANAGP
VAVAVGAQDAVTPPAACQAIAEAAGVPLQIIEGAGHASYIETPDVLNAALAAWLERIAAGER

Download         Length: 909 bp

>T40350 NZ_AP025517:c416729-415821 [Pandoraea sp. NE5]
ATGCAAGCCGAAGCCTTTCAGTCCGAAGTACCCGAAGATGCCGCCGTCGCGCCGCTATGCGCGCGTCTGGACGCCTTCCC
GTACCGCACCGTCGCCACGCGCGCGGGCACCGTGGGCTATCGCAGCGCTGGAACGCAAGCCGAAGGTGCCATGCCGGTCG
TGATGCTGCACGGCATCGGGTCCGGTGCGGCGTCATGGCTCGCGCAATTCGAAGCCACCGGCCTGGATACCGCGCTTTAC
GCATGGGACGCGCCGGGTTACGGGCAGACGACGAATGTCGCCGACGCCGAGCCGCACGCCGACGCCTATGTCGAAGCGCT
CGCGGCGTGGCTCGATGCGCTGGGGCTGGCACGCGTCGCGCTCGTCGGTCATTCGCTGGGCGCGATCATGGCAACCCAGT
TCGCGAGCCGTGCGCCGCAGCGCGTGAGCGGGCTCTTTCTCTGCTCGCCGGCCGGCGGTTACGGCAAGGCCGATGCGCAG
GTACGTGTGAGCAAGCGCGACGGTCGTCTGGCGATGCTCGACAAGCTCGGCCCGACCGGCATGGCGCGCGAACGCAGCGA
CAACCTCGTCGCCCCGAACGCCGCGGCCCTGCCGCGCGCGTGGGTGAAATGGAACATGGCACGCGTGCTGCCCGCGGGCT
ATCGTCAGGCAACGCATCTGCTCTCGAATGGCGACGTCGCCGGCGCGCTAGCGCAATACGTGGCGGCGAATGCGGGCCCG
GTCGCGGTGGCGGTCGGCGCACAGGATGCCGTGACGCCCCCGGCGGCTTGCCAGGCGATCGCCGAGGCGGCCGGTGTGCC
GCTGCAAATCATCGAAGGCGCTGGGCACGCGTCATATATCGAAACGCCAGACGTTCTGAATGCCGCGCTCGCCGCGTGGC
TCGAACGTATCGCGGCAGGAGAACGTTGA

Antitoxin


Download         Length: 290 a.a.        Molecular weight: 31628.14 Da        Isoelectric Point: 6.3597

>AT40350 WP_026132232.1 NZ_AP025517:c415741-414872 [Pandoraea sp. NE5]
MQGEGESEDLVDGAATETRYLVPGLERGLRILTQFSPREPVFSAPELSQRLGIPRTTVFRLLQTLEAMGFLERAGGEKNF
RLGVAVLRLGFEYLSSLELTDLGIPIIERLRDATQLTSHIVIRDGRDIVFVAKAQSVASVFNSIKVNVGTRLPAHATVHG
HVLMGDLTLAELRALYPEKTLEKYTPQTPETITELFERVREDAERGYAVSASSFERGISVVSAPVRNDAGRICAAITVTI
PRATLDASVLDAGLIAQVREAADALSHRLNYRPGSDDRATPYMKSLGLK

Download         Length: 870 bp

>AT40350 NZ_AP025517:c415741-414872 [Pandoraea sp. NE5]
ATGCAAGGCGAGGGCGAGAGCGAAGATCTCGTCGACGGCGCGGCCACCGAGACGCGCTACCTGGTACCGGGCCTTGAGCG
CGGCCTGCGCATTCTCACGCAATTCTCGCCGCGCGAGCCCGTGTTCAGCGCACCGGAGCTCTCGCAGCGACTGGGGATTC
CGCGCACCACGGTCTTCCGCTTGTTGCAAACGCTCGAAGCGATGGGTTTCCTGGAGCGTGCAGGCGGTGAAAAGAATTTT
CGTCTGGGCGTGGCCGTGCTGCGTCTGGGCTTCGAATACCTCAGCTCGCTGGAGCTGACCGATCTGGGCATCCCGATCAT
CGAACGGCTGCGCGACGCCACGCAGCTCACGTCGCACATCGTAATCCGCGACGGGCGCGACATCGTGTTCGTGGCGAAGG
CGCAGAGCGTGGCGAGCGTGTTCAACTCGATCAAGGTCAACGTCGGCACGCGCCTGCCGGCGCATGCGACCGTACACGGC
CATGTGCTGATGGGCGACCTGACGCTGGCCGAGCTTCGCGCGCTGTACCCCGAAAAGACACTCGAAAAATACACGCCGCA
GACACCCGAAACGATCACCGAGCTGTTCGAGCGCGTGCGCGAAGACGCCGAGCGCGGCTACGCCGTGTCGGCCTCGTCGT
TCGAGCGCGGCATCAGCGTGGTGAGTGCCCCGGTGCGCAACGACGCGGGACGCATCTGCGCCGCGATCACCGTCACCATT
CCGCGCGCCACGCTCGATGCGTCGGTGCTCGACGCGGGGCTGATCGCACAGGTGCGCGAGGCGGCCGACGCGTTGTCGCA
CCGCCTGAACTACCGGCCGGGCAGCGACGACCGGGCCACCCCCTACATGAAGTCACTGGGATTGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References