Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 2197877..2199534 Replicon chromosome
Accession NZ_AP025516
Organism Desulfofustis limnaeus strain PPLL

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag DPPLL_RS10215 Protein ID WP_284151093.1
Coordinates 2198224..2199534 (+) Length 437 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag DPPLL_RS10210 Protein ID WP_284151092.1
Coordinates 2197877..2198227 (+) Length 117 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DPPLL_RS10195 (DPPLL_20370) 2192989..2193879 - 891 WP_284151089.1 hypothetical protein -
DPPLL_RS10200 (DPPLL_20380) 2194724..2195362 - 639 WP_284151090.1 YdcF family protein -
DPPLL_RS10205 (DPPLL_20390) 2195371..2197227 - 1857 WP_284151091.1 ABC transporter ATP-binding protein -
DPPLL_RS10210 (DPPLL_20400) 2197877..2198227 + 351 WP_284151092.1 helix-turn-helix domain-containing protein Antitoxin
DPPLL_RS10215 (DPPLL_20410) 2198224..2199534 + 1311 WP_284151093.1 type II toxin-antitoxin system HipA family toxin Toxin
DPPLL_RS10220 (DPPLL_20420) 2199945..2200127 - 183 WP_284151094.1 hypothetical protein -
DPPLL_RS10225 (DPPLL_20430) 2200367..2200855 + 489 WP_284151095.1 helix-turn-helix transcriptional regulator -
DPPLL_RS10230 (DPPLL_20440) 2200848..2201564 + 717 WP_284151096.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
DPPLL_RS10235 (DPPLL_20450) 2201579..2204311 - 2733 WP_284151097.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(170-409)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48807.31 Da        Isoelectric Point: 8.4287

>T40349 WP_284151093.1 NZ_AP025516:2198224-2199534 [Desulfofustis limnaeus]
MTTVAEVRMWGRTIGAVSMADGEDFAAFEYDPAFARSGIEIAPLTMPLTRSVYTFPELSRQTFHGLPGLLADSLPDKFGN
ALINAWLASQGRQPNSFNAVERLCYTGVRGMGALEYAPATGPKGRQATPIQIEKLVALASEILSHRNKLSASFGEAYRAD
AFKDILRIGTSAGGARAKAIIAWNPSTNEVRSGQLPAGDGFEYWLMKFDGVSGNRDKEREEDPSGYGLIEYAYAKMAADA
GITMSDCRLFEENNRHHFMTRRFDRLDGNKKLHMQSLCALAHYDFNRAGAYSYEQALLVIRQLGLPMSAIEELFRRMVFN
IVARNQDDHVKNIAFLMDKSGNWSLAPAFDMTYSFNPSGSWTATHQMTVNGKRDDFTLEDFKACARSASMKRGRAESILK
EVRETVARWREYADEGGVPASWRDQIHKTIRLKTWR

Download         Length: 1311 bp

>T40349 NZ_AP025516:2198224-2199534 [Desulfofustis limnaeus]
ATGACCACCGTTGCCGAGGTGAGGATGTGGGGACGCACCATTGGCGCAGTTTCCATGGCCGATGGAGAGGATTTTGCCGC
CTTTGAGTACGATCCGGCATTTGCCAGAAGCGGGATAGAGATTGCACCGCTGACGATGCCGCTTACAAGGAGCGTCTATA
CCTTCCCCGAACTGTCACGGCAGACCTTTCACGGCCTGCCCGGCCTGCTGGCGGATTCGCTGCCTGACAAATTCGGGAAC
GCCCTGATCAATGCCTGGCTGGCTTCACAGGGTCGACAGCCGAATTCGTTCAATGCTGTCGAACGACTCTGCTACACCGG
TGTACGGGGCATGGGAGCCCTTGAGTATGCCCCGGCAACAGGACCCAAGGGCCGGCAGGCGACACCGATACAGATCGAGA
AACTCGTTGCCCTCGCTTCCGAGATTCTCAGCCACCGGAACAAGCTGAGCGCATCGTTTGGCGAAGCGTATAGAGCGGAC
GCCTTTAAGGATATCCTGCGAATCGGCACATCGGCAGGCGGGGCACGGGCCAAGGCGATTATCGCGTGGAATCCTTCAAC
CAATGAGGTTCGTTCCGGACAACTCCCGGCTGGAGATGGTTTTGAGTACTGGCTGATGAAATTTGATGGGGTCAGCGGCA
ACCGGGACAAGGAACGTGAAGAAGACCCCAGCGGCTACGGTCTCATCGAATATGCCTATGCAAAAATGGCAGCGGATGCC
GGGATCACCATGAGTGACTGCCGTCTTTTCGAGGAAAATAACCGGCACCATTTCATGACACGCCGCTTCGATCGTCTCGA
CGGCAACAAGAAGCTCCACATGCAGTCTCTGTGCGCTCTGGCGCACTATGATTTCAACAGAGCGGGCGCCTATTCGTACG
AACAGGCCCTTCTGGTCATCAGGCAGCTCGGCCTGCCCATGAGTGCAATCGAAGAGCTGTTTCGCCGGATGGTTTTCAAT
ATTGTCGCCCGGAACCAGGATGATCATGTCAAAAATATCGCCTTTTTGATGGATAAATCCGGAAACTGGTCACTGGCACC
GGCTTTTGATATGACCTACAGCTTCAACCCCTCCGGGAGTTGGACTGCCACCCACCAAATGACCGTCAACGGAAAGCGCG
ACGACTTTACCCTCGAGGATTTCAAGGCCTGCGCCAGATCAGCGTCCATGAAACGTGGCCGGGCGGAATCCATTCTGAAG
GAGGTACGGGAAACGGTTGCGCGCTGGCGGGAGTATGCCGATGAAGGCGGTGTCCCCGCTTCCTGGCGCGACCAGATACA
CAAAACCATCCGCTTGAAGACATGGAGATGA

Antitoxin


Download         Length: 117 a.a.        Molecular weight: 13103.98 Da        Isoelectric Point: 9.8756

>AT40349 WP_284151092.1 NZ_AP025516:2197877-2198227 [Desulfofustis limnaeus]
MKISQLLTDDAILTELGSRIARYRIDRQVTQADLAEQAGVSKRTVERVEAGASVQCATIIRILRALDVLQGLDRMIPEPL
PRPLELLKQKGKVRQRASSHRRSDKNPEDWSWGDDS

Download         Length: 351 bp

>AT40349 NZ_AP025516:2197877-2198227 [Desulfofustis limnaeus]
ATGAAGATCTCTCAATTGCTGACGGATGATGCTATTCTCACTGAACTCGGGAGCCGTATCGCTCGCTATCGCATCGATCG
GCAAGTGACGCAAGCAGATCTCGCCGAGCAGGCAGGGGTATCCAAACGCACCGTGGAACGGGTCGAAGCCGGTGCCTCGG
TGCAATGTGCGACAATCATCAGAATCTTGCGAGCCCTCGATGTGCTGCAGGGGCTGGATCGCATGATACCTGAACCACTC
CCCCGCCCTCTCGAGTTGCTGAAGCAGAAAGGAAAAGTGCGGCAGCGCGCCTCTTCACACCGCCGTTCGGATAAAAACCC
TGAAGACTGGTCCTGGGGCGACGACTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References