Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/YafN(antitoxin) |
| Location | 1561731..1562296 | Replicon | chromosome |
| Accession | NZ_AP025514 | ||
| Organism | Vibrio toranzoniae strain CECT 7225 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A109DA03 |
| Locus tag | OCU50_RS06795 | Protein ID | WP_060467712.1 |
| Coordinates | 1561731..1562018 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | I3NI65 |
| Locus tag | OCU50_RS06800 | Protein ID | WP_011080399.1 |
| Coordinates | 1562015..1562296 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OCU50_RS06750 | 1556821..1557273 | - | 453 | WP_060467706.1 | hypothetical protein | - |
| OCU50_RS06755 | 1557344..1557841 | - | 498 | WP_060467707.1 | peptide deformylase | - |
| OCU50_RS06760 | 1557851..1557973 | - | 123 | WP_153011312.1 | DUF3265 domain-containing protein | - |
| OCU50_RS06765 | 1557985..1558497 | - | 513 | WP_060467708.1 | GrpB family protein | - |
| OCU50_RS06770 | 1558699..1559693 | - | 995 | Protein_1303 | IS3 family transposase | - |
| OCU50_RS06775 | 1559765..1560400 | - | 636 | WP_060467709.1 | LysE family transporter | - |
| OCU50_RS06780 | 1560507..1560575 | - | 69 | Protein_1305 | DUF3265 domain-containing protein | - |
| OCU50_RS06785 | 1560560..1561033 | - | 474 | WP_060467710.1 | trimethoprim-resistant dihydrofolate reductase DfrA | - |
| OCU50_RS06790 | 1561191..1561538 | - | 348 | WP_060467711.1 | DUF3024 domain-containing protein | - |
| OCU50_RS06795 | 1561731..1562018 | - | 288 | WP_060467712.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| OCU50_RS06800 | 1562015..1562296 | - | 282 | WP_011080399.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| OCU50_RS06805 | 1562387..1562476 | - | 90 | Protein_1310 | DUF3265 domain-containing protein | - |
| OCU50_RS06810 | 1562733..1562963 | - | 231 | WP_060467713.1 | hypothetical protein | - |
| OCU50_RS06815 | 1562935..1563045 | - | 111 | WP_153011313.1 | DUF3265 domain-containing protein | - |
| OCU50_RS06820 | 1563042..1563581 | - | 540 | WP_060467714.1 | hypothetical protein | - |
| OCU50_RS06825 | 1563770..1563937 | + | 168 | WP_157769186.1 | hypothetical protein | - |
| OCU50_RS06830 | 1563939..1564205 | - | 267 | WP_167350333.1 | hypothetical protein | - |
| OCU50_RS06835 | 1564781..1565254 | - | 474 | WP_060469831.1 | hypothetical protein | - |
| OCU50_RS06840 | 1565373..1566149 | - | 777 | WP_060469829.1 | hypothetical protein | - |
| OCU50_RS06845 | 1566286..1566888 | - | 603 | WP_060469830.1 | DUF922 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | dfrA6 | - | 1558766..1561033 | 2267 | |
| - | inside | Integron | - | - | 1561191..1585250 | 24059 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10973.66 Da Isoelectric Point: 5.0746
>T40347 WP_060467712.1 NZ_AP025514:c1562018-1561731 [Vibrio toranzoniae]
MKVVWSPLALQKLGDAAEFISLDNPVAAENWVNEVFDKTDLLSSMPEMGRMIPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQILTESDV
MKVVWSPLALQKLGDAAEFISLDNPVAAENWVNEVFDKTDLLSSMPEMGRMIPELPHTNYREILFGHYRIIYSLSHEIRV
LTVRNCRQILTESDV
Download Length: 288 bp
>T40347 NZ_AP025514:c1562018-1561731 [Vibrio toranzoniae]
ATGAAAGTAGTCTGGTCACCACTAGCATTACAAAAGTTAGGTGATGCAGCCGAGTTTATTTCACTAGATAATCCAGTGGC
GGCAGAAAACTGGGTCAATGAAGTCTTCGATAAAACAGACCTTCTCTCAAGTATGCCTGAGATGGGGCGAATGATTCCTG
AGCTACCTCATACCAATTATCGCGAAATCTTGTTTGGTCACTATCGCATCATATATAGCCTTAGCCATGAAATTCGCGTT
CTTACGGTACGGAACTGTCGTCAGATTTTAACGGAAAGTGACGTGTAG
ATGAAAGTAGTCTGGTCACCACTAGCATTACAAAAGTTAGGTGATGCAGCCGAGTTTATTTCACTAGATAATCCAGTGGC
GGCAGAAAACTGGGTCAATGAAGTCTTCGATAAAACAGACCTTCTCTCAAGTATGCCTGAGATGGGGCGAATGATTCCTG
AGCTACCTCATACCAATTATCGCGAAATCTTGTTTGGTCACTATCGCATCATATATAGCCTTAGCCATGAAATTCGCGTT
CTTACGGTACGGAACTGTCGTCAGATTTTAACGGAAAGTGACGTGTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10426.96 Da Isoelectric Point: 5.8719
>AT40347 WP_011080399.1 NZ_AP025514:c1562296-1562015 [Vibrio toranzoniae]
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK
MSRIHFDQDIQPLSEFRAGVTSFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLASGLGVSN
EDARAQVLGRIKK
Download Length: 282 bp
>AT40347 NZ_AP025514:c1562296-1562015 [Vibrio toranzoniae]
ATGAGCCGTATCCATTTTGATCAAGATATTCAGCCTTTATCTGAATTTCGTGCTGGCGTAACGTCATTTATTAAACAGAT
TAACGAAACTCGAAGACCATTAGTAATCACGCAACGTGGTAAAGGTGTTGCGGTTGTCCTTGATGTTGCGGAATATGAAG
CAATGCAAGAGAAGATTGAGTTACTGGAAGAAATGCGTACTGCTGAAGCACAATTAGCTTCAGGTTTAGGTGTTTCCAAT
GAAGACGCTCGTGCTCAAGTATTGGGGCGCATTAAGAAATGA
ATGAGCCGTATCCATTTTGATCAAGATATTCAGCCTTTATCTGAATTTCGTGCTGGCGTAACGTCATTTATTAAACAGAT
TAACGAAACTCGAAGACCATTAGTAATCACGCAACGTGGTAAAGGTGTTGCGGTTGTCCTTGATGTTGCGGAATATGAAG
CAATGCAAGAGAAGATTGAGTTACTGGAAGAAATGCGTACTGCTGAAGCACAATTAGCTTCAGGTTTAGGTGTTTCCAAT
GAAGACGCTCGTGCTCAAGTATTGGGGCGCATTAAGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A109DA03 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3S0MQY5 |