Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1355177..1355705 Replicon chromosome
Accession NZ_AP025511
Organism Vibrio tasmaniensis strain LMG 20012

Toxin (Protein)


Gene name relE Uniprot ID K5TRR0
Locus tag OCV44_RS20220 Protein ID WP_005377002.1
Coordinates 1355177..1355467 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID K5UYY9
Locus tag OCV44_RS20225 Protein ID WP_004730320.1
Coordinates 1355457..1355705 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV44_RS20200 1351326..1351850 + 525 WP_170213754.1 hypothetical protein -
OCV44_RS20205 1352019..1352765 + 747 WP_139686040.1 hypothetical protein -
OCV44_RS20210 1353021..1354073 - 1053 WP_139686321.1 transposase -
OCV44_RS20215 1354070..1354957 - 888 WP_139686322.1 site-specific integrase -
OCV44_RS20220 1355177..1355467 - 291 WP_005377002.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCV44_RS20225 1355457..1355705 - 249 WP_004730320.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OCV44_RS20230 1355780..1355872 + 93 Protein_1141 DUF3265 domain-containing protein -
OCV44_RS20235 1356144..1357168 - 1025 Protein_1142 IS110 family transposase -
OCV44_RS20240 1357335..1357790 + 456 WP_246091860.1 DUF2559 family protein -
OCV44_RS20245 1357783..1358385 + 603 WP_139686199.1 putative adenosine monophosphate-protein transferase Fic -
OCV44_RS20250 1358550..1358900 + 351 WP_139686200.1 cupin domain-containing protein -
OCV44_RS20255 1358933..1359409 - 477 Protein_1146 transposase -
OCV44_RS20260 1359540..1359791 + 252 WP_139686201.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
OCV44_RS20265 1359788..1360048 + 261 WP_139686202.1 Txe/YoeB family addiction module toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1352019..1364216 12197
- inside IScluster/Tn - - 1354070..1364216 10146


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11261.25 Da        Isoelectric Point: 10.5932

>T40345 WP_005377002.1 NZ_AP025511:c1355467-1355177 [Vibrio tasmaniensis]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T40345 NZ_AP025511:c1355467-1355177 [Vibrio tasmaniensis]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCACTCAAAGAGTGGAAAAAGCTTGGCTCAACGCTTCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCGCATGTTCCGGCTTCAAAACTCTCTGGAGCTGACAACATGTATAAGATTA
AGCTTCGCCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGAAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCTATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9109.39 Da        Isoelectric Point: 3.9610

>AT40345 WP_004730320.1 NZ_AP025511:c1355705-1355457 [Vibrio tasmaniensis]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLTIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT40345 NZ_AP025511:c1355705-1355457 [Vibrio tasmaniensis]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAATTAAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGTGAACCTGTTGCTGTACTGAACCGAAATGAGCCAGCATTTTATTGCGTACCAGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTAACTATTGCGAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR03

Antitoxin

Source ID Structure
AlphaFold DB A0A0L1LA33

References