Detailed information of TA system TA040342

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1831437..1831950
• Replicon: chromosome
• Accession: NZ_AP025509
• Organism: Vibrio splendidus strain LMG 19031

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCU90_RS25240
• Protein ID: WP_017069754.1
• Coordinates: 1831437..1831703 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2G4B6E9
• Locus tag: OCU90_RS25245
• Protein ID: WP_061021376.1
• Coordinates: 1831693..1831950 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU90_RS25215	1827186..1827713	-	528	WP_054541475.1	N-acetyltransferase	-
OCU90_RS25220	1827756..1828382	-	627	WP_061021370.1	HD domain-containing protein	-
OCU90_RS25225	1828568..1829227	-	660	WP_061021371.1	HAD family phosphatase	-
OCU90_RS25230	1829639..1830967	+	1329	WP_061021373.1	anaerobic C4-dicarboxylate transporter	-
OCU90_RS25235	1831082..1831405	-	324	WP_061021374.1	DUF4144 domain-containing protein	-
OCU90_RS25240	1831437..1831703	-	267	WP_017069754.1	Txe/YoeB family addiction module toxin	Toxin
OCU90_RS25245	1831693..1831950	-	258	WP_061021376.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
OCU90_RS25250	1832137..1832928	-	792	WP_061021378.1	hypothetical protein	-
OCU90_RS25255	1833104..1833805	-	702	WP_061021380.1	flavin reductase	-
OCU90_RS25260	1834039..1835370	+	1332	Protein_1551	ferric reductase-like transmembrane domain-containing protein	-
OCU90_RS25265	1835564..1835971	+	408	WP_026012354.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10524.97 Da
• Isoelectric Point: 9.3651

>T40342 WP_017069754.1 NZ_AP025509:c1831703-1831437 [Vibrio splendidus]
MTNDRKIVFTDNAWEDYLYWQTQDKKTLKKLNKLIEAAKRTPFEGIGKPEPLVGNLSGFWSRRIDDKNRLVYKADDDNFY
IIACRHHY

Nucleotide

• Length: 267 bp

>T40342 NZ_AP025509:c1831703-1831437 [Vibrio splendidus]
ATGACGAATGATCGAAAGATTGTATTTACAGATAATGCTTGGGAAGATTACCTATACTGGCAAACCCAAGACAAGAAAAC
GCTCAAGAAACTAAATAAGTTGATTGAAGCTGCCAAAAGAACGCCCTTTGAAGGGATTGGAAAGCCGGAGCCACTAGTCG
GCAACCTGTCTGGATTTTGGTCAAGACGAATCGATGACAAGAATCGATTAGTGTATAAAGCAGATGACGATAACTTTTAC
ATAATTGCTTGTCGTCACCACTATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9508.52 Da
• Isoelectric Point: 4.2450

>AT40342 WP_061021376.1 NZ_AP025509:c1831950-1831693 [Vibrio splendidus]
MNIVSFTEARNSLKSVLDRVVDDSDVTVITRRDSEDAVVMSLDHFNSMQETLHLMSSPKNAERLAESIAQLEAGNTTVRE
LNNDE

Nucleotide

• Length: 258 bp

>AT40342 NZ_AP025509:c1831950-1831693 [Vibrio splendidus]
ATGAATATTGTTTCTTTTACTGAGGCCAGAAATAGCCTTAAGTCTGTGCTCGATAGAGTGGTAGACGATTCTGATGTTAC
GGTAATAACCAGACGAGATTCAGAAGATGCCGTGGTAATGTCTCTTGATCATTTTAATTCAATGCAAGAAACCTTGCACC
TAATGAGCTCGCCTAAAAACGCTGAAAGATTGGCTGAATCCATTGCTCAACTCGAAGCCGGAAATACAACCGTTCGAGAA
TTAAATAATGACGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A2G4B6E9