Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 276738..277266 Replicon chromosome
Accession NZ_AP025509
Organism Vibrio splendidus strain LMG 19031

Toxin (Protein)


Gene name relE Uniprot ID U4K9G0
Locus tag OCU90_RS18630 Protein ID WP_005464658.1
Coordinates 276738..277028 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID K5UYY9
Locus tag OCU90_RS18635 Protein ID WP_004730320.1
Coordinates 277018..277266 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCU90_RS18605 272517..273542 - 1026 WP_061026117.1 IS110-like element ISVisp6 family transposase -
OCU90_RS18610 273647..274831 + 1185 WP_061025735.1 hypothetical protein -
OCU90_RS18615 274807..274947 + 141 WP_081090029.1 DUF3265 domain-containing protein -
OCU90_RS18620 275180..276208 - 1029 Protein_234 IS110 family transposase -
OCU90_RS18625 276318..276719 + 402 WP_061025733.1 hypothetical protein -
OCU90_RS18630 276738..277028 - 291 WP_005464658.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OCU90_RS18635 277018..277266 - 249 WP_004730320.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OCU90_RS18640 277341..277409 + 69 WP_077672877.1 DUF3265 domain-containing protein -
OCU90_RS18645 277468..277971 + 504 WP_061025731.1 hypothetical protein -
OCU90_RS18650 278107..278802 + 696 WP_061025728.1 hypothetical protein -
OCU90_RS18655 278977..279375 - 399 WP_061025725.1 hypothetical protein -
OCU90_RS18660 279570..280049 + 480 WP_061025723.1 Sbal_3080 family lipoprotein -
OCU90_RS18665 280243..281091 - 849 WP_061025722.1 DMT family transporter -
OCU90_RS18670 281231..282130 + 900 WP_061025720.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 269187..286390 17203


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11277.25 Da        Isoelectric Point: 10.5932

>T40340 WP_005464658.1 NZ_AP025509:c277028-276738 [Vibrio splendidus]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHVPASKLSGSDNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Download         Length: 291 bp

>T40340 NZ_AP025509:c277028-276738 [Vibrio splendidus]
ATGACCTATAAACTCGACTTTAAAAAGAGTGCACTCAAAGAGTGGAAAAAGCTTGGCTCAACGCTTCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCGCATGTTCCGGCTTCAAAACTCTCTGGATCTGACAACATGTATAAGATTA
AGCTGCGCCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTCATCATTGTAACCGTCTTAGCAGTCGGGAAA
CGCGAACGTAGCGATGTTTACCGTAAAGCTATGAAAAGGTTAGATGATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9109.39 Da        Isoelectric Point: 3.9610

>AT40340 WP_004730320.1 NZ_AP025509:c277266-277018 [Vibrio splendidus]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLTIAKERESEESISVNID
DL

Download         Length: 249 bp

>AT40340 NZ_AP025509:c277266-277018 [Vibrio splendidus]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGTGAACCTGTTGCTGTACTGAACCGAAATGAGCCAGCATTTTATTGCGTACCAGCCGAAGCGTACGAAATGATGA
TGGATAGACTCGAAGACCTTGAACTACTAACTATTGCGAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N3LNF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0L1LA33

References