Detailed information of TA system TA040339

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 240053..240593
• Replicon: chromosome
• Accession: NZ_AP025508
• Organism: Vibrio splendidus strain LMG 19031

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCU90_RS01110
• Protein ID: WP_240513394.1
• Coordinates: 240053..240265 (-)
• Length: 71 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2G4AYR2
• Locus tag: OCU90_RS01115
• Protein ID: WP_050652034.1
• Coordinates: 240315..240593 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCU90_RS01090	235468..236415	+	948	Protein_204	IS30 family transposase	-
OCU90_RS01095	237192..237743	+	552	WP_061023842.1	dTDP-4-dehydrorhamnose 3,5-epimerase	-
OCU90_RS01100	237740..238531	+	792	WP_061023844.1	glycosyltransferase family 2 protein	-
OCU90_RS01105	238989..240011	+	1023	WP_061023845.1	hypothetical protein	-
OCU90_RS01110	240053..240265	-	213	WP_240513394.1	type II toxin-antitoxin system YafQ family toxin	Toxin
OCU90_RS01115	240315..240593	-	279	WP_050652034.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
OCU90_RS01120	240920..242023	+	1104	WP_061023848.1	UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase	-
OCU90_RS01125	242298..243362	-	1065	WP_061023891.1	UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase	-
OCU90_RS01130	243714..245246	+	1533	WP_061023849.1	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	wbtL	215744..249702	33958
	-	flank	IS/Tn	-	-	235846..236415	569

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (7-70)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-84)

Sequences

Toxin

Protein

• Length: 71 a.a.
• Molecular weight: 7949.10 Da
• Isoelectric Point: 5.5120

>T40339 WP_240513394.1 NZ_AP025508:c240265-240053 [Vibrio splendidus]
MSIPDIVEVGNIISKLQRGETLDAKNVDHSLTGNWVEFRDCHIKPDLLLIYRIFDGQLQLARVGSHSDLF

Nucleotide

• Length: 213 bp

>T40339 NZ_AP025508:c240265-240053 [Vibrio splendidus]
ATGTCTATTCCTGACATTGTTGAAGTCGGGAACATAATATCCAAGCTGCAACGTGGTGAAACGCTCGATGCTAAAAATGT
CGACCACTCATTAACTGGAAATTGGGTAGAGTTTCGAGACTGCCACATAAAGCCAGATCTATTACTCATCTACCGAATTT
TCGACGGACAACTCCAACTGGCAAGGGTTGGCTCGCATAGTGATTTGTTCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 9965.36 Da
• Isoelectric Point: 5.5732

>AT40339 WP_050652034.1 NZ_AP025508:c240593-240315 [Vibrio splendidus]
MKNEMLSTRIDHDTKVAFTNICDEVGLSTSQAIKLFAKAVINHGGIPFDLRVPQPNDVTSAAIMELIEGKGHKTNSVDSL
LSELTEGKVNNV

Nucleotide

• Length: 279 bp

>AT40339 NZ_AP025508:c240593-240315 [Vibrio splendidus]
ATGAAAAATGAAATGCTGAGTACACGTATTGATCACGATACTAAAGTCGCTTTTACAAATATTTGTGATGAGGTTGGTTT
AAGCACTTCCCAGGCAATAAAACTATTCGCGAAAGCTGTAATCAACCACGGCGGAATACCTTTTGATTTAAGGGTACCAC
AGCCAAACGATGTGACTTCTGCTGCCATCATGGAGCTTATTGAAGGTAAGGGACATAAAACGAATTCAGTTGATTCTCTA
CTATCTGAGCTCACTGAAGGTAAAGTTAACAATGTATGA

Structures

Antitoxin

• AlphaFold DB: A0A2G4AYR2