Detailed information of TA system TA040334

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 407794..408353
• Replicon: chromosome
• Accession: NZ_AP025504
• Organism: Vibrio pelagius strain ATCC 25916

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: vsple_RS16030
• Protein ID: WP_261883834.1
• Coordinates: 408075..408353 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A347UR21
• Locus tag: vsple_RS16025
• Protein ID: WP_005398409.1
• Coordinates: 407794..408078 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
vsple_RS15980	403098..403343	-	246	WP_261883826.1	hypothetical protein	-
vsple_RS15985	403457..403873	-	417	WP_261883827.1	hypothetical protein	-
vsple_RS15990	404606..405304	-	699	WP_261883828.1	hypothetical protein	-
vsple_RS15995	405546..405728	-	183	WP_261883829.1	hypothetical protein	-
vsple_RS16000	405757..406371	-	615	WP_261883830.1	LysE family translocator	-
vsple_RS16005	406423..406719	-	297	WP_261883831.1	antibiotic biosynthesis monooxygenase	-
vsple_RS16010	406830..407072	+	243	WP_261883832.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
vsple_RS16015	407079..407373	+	295	Protein_338	type II toxin-antitoxin system RelE/ParE family toxin	-
vsple_RS16020	407482..407724	+	243	WP_261883833.1	transposase	-
vsple_RS16025	407794..408078	+	285	WP_005398409.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
vsple_RS16030	408075..408353	+	279	WP_261883834.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
vsple_RS16035	408445..409094	+	650	Protein_342	transposase	-
vsple_RS16040	409641..410156	-	516	WP_261883835.1	hypothetical protein	-
vsple_RS16045	410275..411429	+	1155	WP_261881728.1	IS110 family transposase	-
vsple_RS16050	411823..412614	-	792	WP_261883836.1	DUF4263 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	394060..412614	18554

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10895.56 Da
• Isoelectric Point: 4.3430

>T40334 WP_261883834.1 NZ_AP025504:408075-408353 [Vibrio pelagius]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDNLIEAKVENLLEQSLMGVQRDSIRGRLLIIPEISMIVSYWIEGDIIRVM
RVLHQKQKFPAD

Nucleotide

• Length: 279 bp

>T40334 NZ_AP025504:408075-408353 [Vibrio pelagius]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTTGAGTTTCTCTATGACTTCAACCCTGATGCTGC
AGAAAAAACAGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAATCTTTAATGGGTGTACAACGAGATAGCA
TCCGCGGACGATTGCTCATCATTCCTGAGATTTCGATGATTGTCTCTTACTGGATTGAGGGCGATATCATCCGAGTTATG
CGTGTACTACACCAGAAACAAAAATTCCCTGCGGATTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 11069.40 Da
• Isoelectric Point: 9.2167

>AT40334 WP_005398409.1 NZ_AP025504:407794-408078 [Vibrio pelagius]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKTLSHDAWLTEQVNLAFEKFDSGKSVFVEHQTAKSR
MEERKARIRNRGKQ

Nucleotide

• Length: 285 bp

>AT40334 NZ_AP025504:407794-408078 [Vibrio pelagius]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGCCGAAC
TCTAAGTGATGCTTGTCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCTGGAAAATCCGTTTTCGTTGAGCACCAAACGGCTAAGTCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A347UR21