Detailed information of TA system TA040333

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1949158..1949705
• Replicon: chromosome
• Accession: NZ_AP025503
• Organism: Vibrio pelagius strain ATCC 25916

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: vsple_RS08360
• Protein ID: WP_255230509.1
• Coordinates: 1949158..1949460 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: vsple_RS08365
• Protein ID: WP_261881724.1
• Coordinates: 1949448..1949705 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
vsple_RS08320	1944521..1944799	+	279	WP_255230512.1	50S ribosomal protein L25	-
vsple_RS08325	1945085..1945450	-	366	WP_261881719.1	VOC family protein	-
vsple_RS08330	1945498..1945611	-	114	Protein_1577	DUF3265 domain-containing protein	-
vsple_RS08335	1945577..1946215	-	639	WP_261881720.1	DJ-1/PfpI family protein	-
vsple_RS08340	1946339..1947112	-	774	WP_261881721.1	phosphotransferase	-
vsple_RS08345	1947248..1947757	-	510	WP_261881722.1	hypothetical protein	-
vsple_RS08350	1948307..1948621	-	315	WP_255230510.1	DNA-binding transcriptional regulator	-
vsple_RS08355	1948608..1948940	-	333	WP_261881723.1	type II toxin-antitoxin system RelE/ParE family toxin	-
vsple_RS08360	1949158..1949460	-	303	WP_255230509.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
vsple_RS08365	1949448..1949705	-	258	WP_261881724.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
vsple_RS08370	1949787..1949876	-	90	WP_261883154.1	DUF3265 domain-containing protein	-
vsple_RS08375	1949889..1950107	+	219	Protein_1586	IS110 family transposase	-
vsple_RS08380	1950130..1950456	-	327	WP_261881725.1	hypothetical protein	-
vsple_RS08385	1950596..1951749	+	1154	Protein_1588	IS110 family transposase	-
vsple_RS08390	1952065..1952157	-	93	WP_261881726.1	DUF3265 domain-containing protein	-
vsple_RS08395	1952172..1952981	-	810	WP_047111987.1	hypothetical protein	-
vsple_RS08400	1953162..1954034	-	873	WP_261881727.1	putative phage abortive infection protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1945577..1959745	14168

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11639.54 Da
• Isoelectric Point: 5.1765

>T40333 WP_255230509.1 NZ_AP025503:c1949460-1949158 [Vibrio pelagius]
MAEVIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FVLFVMRVERDLRKFLLGKQ

Nucleotide

• Length: 303 bp

>T40333 NZ_AP025503:c1949460-1949158 [Vibrio pelagius]
ATGGCTGAAGTAATCTGGACTGAACCAGCGTTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTACAAACGATCTTTTCCAAAGTCGAACGCCTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGAGCTAGAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTGTTCTGTTCGTTATGCGTGTAGAGAGAGATTTGCGTAAATTCTTGTTGGGTAAGCAATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9634.15 Da
• Isoelectric Point: 6.7269

>AT40333 WP_261881724.1 NZ_AP025503:c1949705-1949448 [Vibrio pelagius]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERAIVDGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT40333 NZ_AP025503:c1949705-1949448 [Vibrio pelagius]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATCCTCGCCGATCTCCATGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCTGCTTATCTAGTTGATGTTGATGATTACGAATTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCAATAGTTGATGGTAAAGTGGTAAGTCATGATGAAGCCAAGGACAAAATG
TCGAAATGGCTGAAGTAA