Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 730384..731933 Replicon chromosome
Accession NZ_AP025503
Organism Vibrio pelagius strain ATCC 25916

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag vsple_RS03195 Protein ID WP_261882657.1
Coordinates 730384..731685 (-) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag vsple_RS03200 Protein ID WP_102385596.1
Coordinates 731685..731933 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
vsple_RS03170 725877..726578 + 702 WP_261882652.1 DUF429 domain-containing protein -
vsple_RS03175 726657..727121 - 465 WP_261882653.1 copper chaperone PCu(A)C -
vsple_RS03180 727157..727312 - 156 WP_261882654.1 hypothetical protein -
vsple_RS03185 727436..727849 - 414 WP_261882655.1 hypothetical protein -
vsple_RS03190 728264..730147 + 1884 WP_261882656.1 RimK/LysX family protein -
vsple_RS03195 730384..731685 - 1302 WP_261882657.1 type II toxin-antitoxin system HipA family toxin Toxin
vsple_RS03200 731685..731933 - 249 WP_102385596.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
vsple_RS03205 732255..732404 - 150 Protein_589 IS3 family transposase -
vsple_RS03210 732486..732833 - 348 WP_261882658.1 hypothetical protein -
vsple_RS03220 733542..734027 - 486 WP_032551363.1 SsrA-binding protein SmpB -
vsple_RS03225 734146..734574 + 429 WP_255231321.1 SRPBCC family protein -
vsple_RS03230 734577..734885 + 309 WP_255231320.1 RnfH family protein -
vsple_RS03235 734955..735314 - 360 WP_255231319.1 outer membrane protein assembly factor BamE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 48684.37 Da        Isoelectric Point: 8.5278

>T40331 WP_261882657.1 NZ_AP025503:c731685-730384 [Vibrio pelagius]
MQKLIAYMNGELVGTLEKHKNGAHTFQYNKNWLTNAVTRPLSLSLKLQLPAITSDAVINYFDNLLPDSPQVRDRIVARYK
ASSKQPFDLLKEIGKDSVGAIALLPPDRPYKKEPLSYEVLDDKKLETVLSAYKSDIPLGMLEEEEDFRISVAGAQEKTAL
LFVDEQWCIPKGNTPTTHIIKLPIGEIQQANATLDLKDSVENEYLCIELARALGFAVPNVQIIQTDNIKALAVERFDRRW
TKDRAGLLRLPQEDICQVFGMPSSIKYESQGGPGIAQIMELLMGSSNALEDRYNFMRFQVFQWLIGATDGHAKNFSIYID
KGGSYRLTPFYDILSAYPLLGGKGLNIRKLKLAMGLKATKGKKYEISKILPRHFLDTAKAVNFNQDTMQEIIDEMKDALP
KAMLQVSATLPKGFPEHIVSSIFENTQKIVKKI

Download         Length: 1302 bp

>T40331 NZ_AP025503:c731685-730384 [Vibrio pelagius]
ATGCAGAAGCTAATCGCATACATGAATGGTGAACTTGTTGGTACTCTAGAGAAACATAAGAATGGTGCTCACACTTTTCA
ATATAATAAAAACTGGTTAACCAATGCGGTAACTCGACCACTATCATTGTCTTTAAAACTTCAATTACCAGCTATCACTT
CCGATGCAGTTATAAACTATTTTGACAATCTCTTGCCAGACAGCCCTCAAGTCAGAGATAGAATAGTTGCAAGGTACAAG
GCGTCATCCAAACAACCATTTGATCTACTAAAAGAAATAGGAAAAGACAGTGTTGGTGCGATTGCTTTACTTCCTCCAGA
CCGCCCCTATAAAAAAGAGCCACTTAGCTACGAAGTCCTTGATGACAAAAAACTAGAAACTGTTCTTTCTGCATACAAGT
CTGATATTCCGCTCGGAATGCTCGAAGAAGAAGAAGACTTTAGAATCTCCGTGGCAGGTGCTCAAGAGAAAACGGCTCTC
CTATTCGTTGATGAGCAATGGTGTATACCGAAAGGAAACACCCCCACCACTCACATCATCAAACTGCCAATAGGCGAAAT
ACAACAAGCCAACGCGACCCTAGATCTCAAAGATAGCGTAGAAAACGAGTACCTTTGCATTGAGTTAGCTAGAGCTCTAG
GGTTTGCAGTTCCCAACGTCCAAATAATCCAAACAGACAACATTAAAGCTTTAGCTGTAGAACGCTTTGATAGACGCTGG
ACAAAAGACAGAGCAGGCTTGCTACGCTTACCTCAGGAAGATATCTGCCAAGTATTTGGTATGCCATCATCCATTAAGTA
CGAATCTCAAGGTGGCCCTGGCATAGCTCAGATCATGGAGTTATTAATGGGGTCAAGTAATGCACTAGAAGATCGGTATA
ACTTCATGAGGTTTCAAGTATTTCAATGGCTCATTGGCGCTACAGATGGACATGCTAAAAACTTTTCTATCTATATTGAT
AAAGGAGGCAGCTACAGACTCACTCCATTCTACGATATTTTGTCAGCCTACCCACTACTGGGAGGAAAAGGGCTCAATAT
CAGAAAGCTTAAGCTGGCGATGGGATTGAAAGCAACAAAGGGCAAGAAGTATGAAATCAGTAAAATCCTGCCTCGTCACT
TTTTGGATACAGCTAAAGCTGTAAACTTTAATCAAGACACGATGCAAGAGATAATTGATGAAATGAAAGATGCCTTACCG
AAGGCGATGTTACAGGTAAGTGCTACATTGCCTAAAGGCTTTCCTGAGCATATCGTGAGCTCAATTTTTGAGAATACTCA
GAAAATCGTTAAGAAGATTTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9307.64 Da        Isoelectric Point: 6.2564

>AT40331 WP_102385596.1 NZ_AP025503:c731933-731685 [Vibrio pelagius]
MIYSPKQLADMMLLIRQKNGWTQSELAKKVGIKQATISNFENNPNKTTLATFFKLAQAMDLTLSIQEKSQVASLNENDDE
SW

Download         Length: 249 bp

>AT40331 NZ_AP025503:c731933-731685 [Vibrio pelagius]
ATGATATATAGTCCAAAACAATTAGCAGATATGATGTTACTGATACGTCAGAAGAATGGATGGACGCAGTCAGAACTAGC
AAAAAAAGTCGGCATCAAGCAAGCTACAATCTCGAACTTCGAAAACAACCCTAACAAAACAACACTTGCTACCTTCTTTA
AGCTTGCCCAGGCTATGGATCTAACATTGAGTATCCAAGAGAAATCACAGGTAGCTTCGTTAAATGAAAATGATGATGAG
AGCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References