Detailed information of TA system TA040330

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 181040..181602
• Replicon: plasmid p1
• Accession: NZ_AP025501
• Organism: Vibrio lentus strain LMG 21034

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: OCV49_RS26080
• Protein ID: WP_192854454.1
• Coordinates: 181300..181602 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: OCV49_RS26075
• Protein ID: WP_192854456.1
• Coordinates: 181040..181300 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV49_RS26050	176256..176756	-	501	WP_171388184.1	hypothetical protein	-
OCV49_RS26055	177626..177907	+	282	WP_261891736.1	cysteine peptidase family C39 domain-containing protein	-
OCV49_RS26060	177897..178391	+	495	WP_225998596.1	ATP-binding cassette domain-containing protein	-
OCV49_RS26065	179211..180209	-	999	WP_192854457.1	hypothetical protein	-
OCV49_RS26070	180405..180912	-	508	Protein_170	recombinase family protein	-
OCV49_RS26075	181040..181300	+	261	WP_192854456.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCV49_RS26080	181300..181602	+	303	WP_192854454.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV49_RS26085	181606..182111	-	506	Protein_173	recombinase family protein	-
OCV49_RS26090	182248..183162	-	915	WP_171388188.1	AAA family ATPase	-
OCV49_RS26095	183159..184184	-	1026	WP_192854453.1	DNA mismatch repair protein	-
OCV49_RS26100	185501..185740	+	240	Protein_176	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..251461	251461

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11839.71 Da
• Isoelectric Point: 9.8774

>T40330 WP_192854454.1 NZ_AP025501:181300-181602 [Vibrio lentus]
MMHYKLSSAAQSDLIEIRRYTLERRGQTQWTTYFSELKQSMELLANNKLLGIEVFELGQNYFRFPLKHHVIYYIQKQEHI
VIAAVLSKHISPAKHFSQIS

Nucleotide

• Length: 303 bp

>T40330 NZ_AP025501:181300-181602 [Vibrio lentus]
ATGATGCACTATAAGCTTTCTTCTGCAGCGCAATCTGATCTCATTGAGATTCGTCGCTATACATTAGAGCGAAGGGGGCA
AACACAATGGACTACTTACTTTTCAGAACTAAAGCAATCTATGGAATTACTGGCGAACAACAAGTTGCTCGGCATAGAAG
TTTTTGAACTGGGCCAAAACTACTTCCGGTTTCCTTTAAAGCACCATGTAATTTATTACATCCAGAAACAAGAGCACATA
GTTATTGCAGCCGTTCTGAGTAAACACATATCTCCAGCTAAGCACTTTTCACAAATCTCTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9601.95 Da
• Isoelectric Point: 4.2821

>AT40330 WP_192854456.1 NZ_AP025501:181040-181300 [Vibrio lentus]
MQSLTANTAKTKFGDLLMKVQREPIQINKNGSPVAVMMSCEEYEQLEALKLMVVKSRFEQAEADALSDNLVDGNDFMNAL
DQGKFD

Nucleotide

• Length: 261 bp

>AT40330 NZ_AP025501:181040-181300 [Vibrio lentus]
ATGCAATCACTTACAGCTAATACAGCTAAAACCAAATTTGGCGATTTGTTGATGAAAGTTCAACGTGAACCCATACAAAT
CAATAAGAACGGCTCACCAGTTGCGGTGATGATGTCTTGTGAAGAATATGAGCAACTTGAAGCTCTGAAATTGATGGTTG
TTAAATCACGCTTCGAACAAGCAGAAGCCGATGCTCTATCAGATAACCTAGTTGACGGTAACGACTTCATGAATGCACTT
GACCAAGGTAAATTTGATTAA