40329

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 111289..112946 Replicon plasmid p1
Accession NZ_AP025501
Organism Vibrio lentus strain LMG 21034

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag OCV49_RS25735 Protein ID WP_261891713.1
Coordinates 111630..112946 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag OCV49_RS25730 Protein ID WP_225998621.1
Coordinates 111289..111636 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV49_RS25710 106719..107154 - 436 Protein_98 GNAT family N-acetyltransferase -
OCV49_RS25715 107291..108364 - 1074 WP_192854688.1 hypothetical protein -
OCV49_RS25720 108876..110348 - 1473 WP_192854744.1 group II intron reverse transcriptase/maturase -
OCV49_RS25725 110581..110724 - 144 WP_192854745.1 hypothetical protein -
OCV49_RS25730 111289..111636 + 348 WP_225998621.1 helix-turn-helix transcriptional regulator Antitoxin
OCV49_RS25735 111630..112946 + 1317 WP_261891713.1 type II toxin-antitoxin system HipA family toxin Toxin
OCV49_RS25740 113479..114228 + 750 WP_192854761.1 alpha/beta hydrolase -
OCV49_RS25745 114767..116047 - 1281 WP_192854587.1 MATE family efflux transporter -
OCV49_RS25750 116092..116433 - 342 WP_192854589.1 hypothetical protein -
OCV49_RS25755 116478..117185 - 708 WP_192854591.1 orotidine-5'-phosphate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..251461 251461


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(175-411)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-69)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 48760.01 Da        Isoelectric Point: 5.4900

>T40329 WP_261891713.1 NZ_AP025501:111630-112946 [Vibrio lentus]
MVGKKYDTAKVSIFGKDVGALAEDTTTGIVSFEYFDEWLKTGFAISQRLPLEAGAFSFPTLNYPTYKGLPAAFADTLPDD
FGNAVINAWLARQGRDPQSFSALERLLYTGSRGMGALEYTPALADTNKKQDESIKLDSLVAMAQLVLDERNNLDETIINE
QEAEQALTGILQVGTSAGGARAKAVIAVNSDRTQIRSGQVNAPKGFEHFLLKFDGVVERSSTSEVFGDPKGFGLMEYAYY
LMAKKAGINISHCELLKENGRAHFMTKRFDRVGNEKVHYQSLCAMDHADFKQPGGYSYEELFTLLRSLRLDRLSALEVFR
RMAFNVIARNHDDHTKNWGFVINSTNKWELAPAFDLAYSYKPGSPWVESHQMSINGKRDNFTKQDLLGVVPPSLQGEAEA
ILSEVHATVTTWREIARDVGVEPSFLDEIESNHRLNLV

Download         Length: 1317 bp

>T40329 NZ_AP025501:111630-112946 [Vibrio lentus]
TTGGTAGGCAAGAAATACGACACAGCAAAAGTCAGTATATTCGGTAAAGATGTCGGCGCTCTAGCTGAAGATACTACGAC
CGGAATCGTTAGCTTTGAATACTTCGATGAGTGGCTAAAAACTGGGTTTGCCATTTCACAAAGACTCCCTCTTGAGGCTG
GCGCGTTTAGTTTTCCCACTCTGAATTATCCAACCTATAAAGGCCTACCTGCAGCCTTCGCAGATACTCTACCCGATGAC
TTTGGTAATGCCGTAATCAATGCCTGGCTTGCACGCCAGGGCCGAGACCCACAATCTTTCAGTGCATTGGAAAGACTGCT
CTATACCGGTTCACGAGGTATGGGAGCTCTTGAGTACACACCCGCATTAGCTGACACGAATAAAAAACAAGATGAATCAA
TTAAACTCGACTCACTTGTAGCAATGGCACAACTCGTCCTTGACGAAAGAAACAACCTAGATGAAACCATCATCAATGAG
CAGGAAGCGGAGCAAGCCTTAACTGGCATCCTTCAAGTCGGCACCTCAGCTGGCGGTGCTAGAGCTAAAGCGGTTATCGC
AGTCAACTCAGATCGCACGCAAATACGCTCAGGTCAGGTAAATGCTCCCAAAGGCTTCGAACACTTCCTATTAAAGTTTG
ATGGCGTTGTCGAACGCTCATCCACTAGTGAGGTATTTGGTGATCCTAAAGGCTTCGGCTTAATGGAATATGCCTATTAC
TTAATGGCCAAAAAAGCCGGCATCAATATCTCACATTGTGAATTATTAAAAGAAAACGGGCGTGCTCACTTCATGACAAA
ACGATTTGACCGCGTTGGAAACGAAAAAGTGCATTATCAATCTTTATGCGCTATGGATCACGCAGATTTCAAACAACCTG
GCGGTTACAGTTATGAAGAACTCTTCACCCTATTGCGCTCACTGAGACTTGATCGACTATCAGCACTTGAAGTGTTTAGA
CGCATGGCCTTTAACGTGATTGCCCGCAACCACGATGACCACACAAAAAACTGGGGATTCGTTATCAATAGTACGAACAA
GTGGGAACTCGCGCCAGCATTCGATCTAGCATATAGCTACAAACCCGGCTCGCCTTGGGTAGAGAGCCATCAAATGTCGA
TCAACGGTAAGCGAGACAATTTTACCAAACAAGACTTACTAGGAGTCGTACCTCCATCACTACAAGGTGAGGCAGAAGCT
ATTTTAAGTGAGGTTCATGCCACCGTGACAACATGGCGAGAAATAGCAAGAGACGTAGGTGTCGAACCATCGTTCCTTGA
TGAAATAGAGTCCAACCACAGACTCAATCTAGTATGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13075.17 Da        Isoelectric Point: 10.5772

>AT40329 WP_225998621.1 NZ_AP025501:111289-111636 [Vibrio lentus]
MKSNIYAMSDEALISELGRRIERRRLDHRSSLTQAQLAKKAGISRSTYQNMIEGRSTLINVIKVLRVLDSLEGIESFLPD
PGISPVQLLKMKGKVRQRVKLASTPQQPKEEDLDW

Download         Length: 348 bp

>AT40329 NZ_AP025501:111289-111636 [Vibrio lentus]
ATGAAGTCGAATATATACGCAATGTCAGATGAAGCACTGATCAGTGAACTTGGCCGTCGAATCGAAAGACGAAGACTCGA
TCACCGTTCGTCACTTACTCAAGCACAGTTAGCTAAAAAGGCCGGAATCAGCCGGTCAACATACCAAAATATGATAGAGG
GTAGATCAACCCTAATAAACGTCATCAAGGTACTCAGAGTGTTAGATTCATTGGAAGGCATTGAATCTTTCCTACCAGAC
CCTGGAATTAGCCCAGTACAACTTCTCAAAATGAAAGGGAAAGTACGCCAAAGGGTAAAGCTGGCCTCAACGCCACAACA
ACCTAAAGAGGAGGACTTAGATTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References