Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 48937..50594 Replicon plasmid p1
Accession NZ_AP025501
Organism Vibrio lentus strain LMG 21034

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag OCV49_RS25445 Protein ID WP_261891713.1
Coordinates 48937..50253 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag OCV49_RS25450 Protein ID WP_225998621.1
Coordinates 50247..50594 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV49_RS25425 44412..44615 - 204 WP_192854678.1 hypothetical protein -
OCV49_RS25430 44855..45292 + 438 WP_192854770.1 IS200/IS605 family transposase -
OCV49_RS25435 45741..46211 - 471 WP_192854756.1 hypothetical protein -
OCV49_RS25440 47126..48597 + 1472 Protein_44 group II intron reverse transcriptase/maturase -
OCV49_RS25445 48937..50253 - 1317 WP_261891713.1 type II toxin-antitoxin system HipA family toxin Toxin
OCV49_RS25450 50247..50594 - 348 WP_225998621.1 helix-turn-helix transcriptional regulator Antitoxin
OCV49_RS25455 51391..51666 + 276 WP_171388226.1 helix-turn-helix transcriptional regulator -
OCV49_RS25460 51659..52894 + 1236 WP_048657858.1 type II toxin-antitoxin system HipA family toxin -
OCV49_RS25465 53241..54272 - 1032 Protein_49 IS110 family transposase -
OCV49_RS25470 54532..55329 + 798 WP_192854684.1 CPBP family intramembrane metalloprotease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..251461 251461
- flank IS/Tn - - 44855..45292 437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(175-411)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-69)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 48760.01 Da        Isoelectric Point: 5.4900

>T40328 WP_261891713.1 NZ_AP025501:c50253-48937 [Vibrio lentus]
MVGKKYDTAKVSIFGKDVGALAEDTTTGIVSFEYFDEWLKTGFAISQRLPLEAGAFSFPTLNYPTYKGLPAAFADTLPDD
FGNAVINAWLARQGRDPQSFSALERLLYTGSRGMGALEYTPALADTNKKQDESIKLDSLVAMAQLVLDERNNLDETIINE
QEAEQALTGILQVGTSAGGARAKAVIAVNSDRTQIRSGQVNAPKGFEHFLLKFDGVVERSSTSEVFGDPKGFGLMEYAYY
LMAKKAGINISHCELLKENGRAHFMTKRFDRVGNEKVHYQSLCAMDHADFKQPGGYSYEELFTLLRSLRLDRLSALEVFR
RMAFNVIARNHDDHTKNWGFVINSTNKWELAPAFDLAYSYKPGSPWVESHQMSINGKRDNFTKQDLLGVVPPSLQGEAEA
ILSEVHATVTTWREIARDVGVEPSFLDEIESNHRLNLV

Download         Length: 1317 bp

>T40328 NZ_AP025501:c50253-48937 [Vibrio lentus]
TTGGTAGGCAAGAAATACGACACAGCAAAAGTCAGTATATTCGGTAAAGATGTCGGCGCTCTAGCTGAAGATACTACGAC
CGGAATCGTTAGCTTTGAATACTTCGATGAGTGGCTAAAAACTGGGTTTGCCATTTCACAAAGACTCCCTCTTGAGGCTG
GCGCGTTTAGTTTTCCCACTCTGAATTATCCAACCTATAAAGGCCTACCTGCAGCCTTCGCAGATACTCTACCCGATGAC
TTTGGTAATGCCGTAATCAATGCCTGGCTTGCACGCCAGGGCCGAGACCCACAATCTTTCAGTGCATTGGAAAGACTGCT
CTATACCGGTTCACGAGGTATGGGAGCTCTTGAGTACACACCCGCATTAGCTGACACGAATAAAAAACAAGATGAATCAA
TTAAACTCGACTCACTTGTAGCAATGGCACAACTCGTCCTTGACGAAAGAAACAACCTAGATGAAACCATCATCAATGAG
CAGGAAGCGGAGCAAGCCTTAACTGGCATCCTTCAAGTCGGCACCTCAGCTGGCGGTGCTAGAGCTAAAGCGGTTATCGC
AGTCAACTCAGATCGCACGCAAATACGCTCAGGTCAGGTAAATGCTCCCAAAGGCTTCGAACACTTCCTATTAAAGTTTG
ATGGCGTTGTCGAACGCTCATCCACTAGTGAGGTATTTGGTGATCCTAAAGGCTTCGGCTTAATGGAATATGCCTATTAC
TTAATGGCCAAAAAAGCCGGCATCAATATCTCACATTGTGAATTATTAAAAGAAAACGGGCGTGCTCACTTCATGACAAA
ACGATTTGACCGCGTTGGAAACGAAAAAGTGCATTATCAATCTTTATGCGCTATGGATCACGCAGATTTCAAACAACCTG
GCGGTTACAGTTATGAAGAACTCTTCACCCTATTGCGCTCACTGAGACTTGATCGACTATCAGCACTTGAAGTGTTTAGA
CGCATGGCCTTTAACGTGATTGCCCGCAACCACGATGACCACACAAAAAACTGGGGATTCGTTATCAATAGTACGAACAA
GTGGGAACTCGCGCCAGCATTCGATCTAGCATATAGCTACAAACCCGGCTCGCCTTGGGTAGAGAGCCATCAAATGTCGA
TCAACGGTAAGCGAGACAATTTTACCAAACAAGACTTACTAGGAGTCGTACCTCCATCACTACAAGGTGAGGCAGAAGCT
ATTTTAAGTGAGGTTCATGCCACCGTGACAACATGGCGAGAAATAGCAAGAGACGTAGGTGTCGAACCATCGTTCCTTGA
TGAAATAGAGTCCAACCACAGACTCAACCTAGTATGA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13075.17 Da        Isoelectric Point: 10.5772

>AT40328 WP_225998621.1 NZ_AP025501:c50594-50247 [Vibrio lentus]
MKSNIYAMSDEALISELGRRIERRRLDHRSSLTQAQLAKKAGISRSTYQNMIEGRSTLINVIKVLRVLDSLEGIESFLPD
PGISPVQLLKMKGKVRQRVKLASTPQQPKEEDLDW

Download         Length: 348 bp

>AT40328 NZ_AP025501:c50594-50247 [Vibrio lentus]
ATGAAGTCGAATATATACGCAATGTCAGATGAAGCACTGATCAGTGAACTTGGCCGTCGAATCGAAAGACGAAGGCTCGA
TCACCGTTCGTCACTTACTCAAGCACAGTTAGCTAAAAAGGCCGGAATCAGCCGGTCAACATACCAAAATATGATAGAGG
GTAGATCAACCCTAATAAACGTCATCAAGGTACTCAGAGTGTTAGATTCATTGGAAGGCATTGAATCTTTCCTACCAGAC
CCTGGAATTAGCCCAGTACAACTTCTCAAAATGAAAGGGAAAGTACGCCAAAGGGTAAAGCTGGCCTCAACGCCACAACA
ACCTAAAGAGGAGGACTTAGATTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References