Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
Location | 48937..50594 | Replicon | plasmid p1 |
Accession | NZ_AP025501 | ||
Organism | Vibrio lentus strain LMG 21034 |
Toxin (Protein)
Gene name | HipA3 | Uniprot ID | - |
Locus tag | OCV49_RS25445 | Protein ID | WP_261891713.1 |
Coordinates | 48937..50253 (-) | Length | 439 a.a. |
Antitoxin (Protein)
Gene name | HipB3 | Uniprot ID | - |
Locus tag | OCV49_RS25450 | Protein ID | WP_225998621.1 |
Coordinates | 50247..50594 (-) | Length | 116 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OCV49_RS25425 | 44412..44615 | - | 204 | WP_192854678.1 | hypothetical protein | - |
OCV49_RS25430 | 44855..45292 | + | 438 | WP_192854770.1 | IS200/IS605 family transposase | - |
OCV49_RS25435 | 45741..46211 | - | 471 | WP_192854756.1 | hypothetical protein | - |
OCV49_RS25440 | 47126..48597 | + | 1472 | Protein_44 | group II intron reverse transcriptase/maturase | - |
OCV49_RS25445 | 48937..50253 | - | 1317 | WP_261891713.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
OCV49_RS25450 | 50247..50594 | - | 348 | WP_225998621.1 | helix-turn-helix transcriptional regulator | Antitoxin |
OCV49_RS25455 | 51391..51666 | + | 276 | WP_171388226.1 | helix-turn-helix transcriptional regulator | - |
OCV49_RS25460 | 51659..52894 | + | 1236 | WP_048657858.1 | type II toxin-antitoxin system HipA family toxin | - |
OCV49_RS25465 | 53241..54272 | - | 1032 | Protein_49 | IS110 family transposase | - |
OCV49_RS25470 | 54532..55329 | + | 798 | WP_192854684.1 | CPBP family intramembrane metalloprotease | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..251461 | 251461 | |
- | flank | IS/Tn | - | - | 44855..45292 | 437 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 439 a.a. Molecular weight: 48760.01 Da Isoelectric Point: 5.4900
>T40328 WP_261891713.1 NZ_AP025501:c50253-48937 [Vibrio lentus]
MVGKKYDTAKVSIFGKDVGALAEDTTTGIVSFEYFDEWLKTGFAISQRLPLEAGAFSFPTLNYPTYKGLPAAFADTLPDD
FGNAVINAWLARQGRDPQSFSALERLLYTGSRGMGALEYTPALADTNKKQDESIKLDSLVAMAQLVLDERNNLDETIINE
QEAEQALTGILQVGTSAGGARAKAVIAVNSDRTQIRSGQVNAPKGFEHFLLKFDGVVERSSTSEVFGDPKGFGLMEYAYY
LMAKKAGINISHCELLKENGRAHFMTKRFDRVGNEKVHYQSLCAMDHADFKQPGGYSYEELFTLLRSLRLDRLSALEVFR
RMAFNVIARNHDDHTKNWGFVINSTNKWELAPAFDLAYSYKPGSPWVESHQMSINGKRDNFTKQDLLGVVPPSLQGEAEA
ILSEVHATVTTWREIARDVGVEPSFLDEIESNHRLNLV
MVGKKYDTAKVSIFGKDVGALAEDTTTGIVSFEYFDEWLKTGFAISQRLPLEAGAFSFPTLNYPTYKGLPAAFADTLPDD
FGNAVINAWLARQGRDPQSFSALERLLYTGSRGMGALEYTPALADTNKKQDESIKLDSLVAMAQLVLDERNNLDETIINE
QEAEQALTGILQVGTSAGGARAKAVIAVNSDRTQIRSGQVNAPKGFEHFLLKFDGVVERSSTSEVFGDPKGFGLMEYAYY
LMAKKAGINISHCELLKENGRAHFMTKRFDRVGNEKVHYQSLCAMDHADFKQPGGYSYEELFTLLRSLRLDRLSALEVFR
RMAFNVIARNHDDHTKNWGFVINSTNKWELAPAFDLAYSYKPGSPWVESHQMSINGKRDNFTKQDLLGVVPPSLQGEAEA
ILSEVHATVTTWREIARDVGVEPSFLDEIESNHRLNLV
Download Length: 1317 bp
>T40328 NZ_AP025501:c50253-48937 [Vibrio lentus]
TTGGTAGGCAAGAAATACGACACAGCAAAAGTCAGTATATTCGGTAAAGATGTCGGCGCTCTAGCTGAAGATACTACGAC
CGGAATCGTTAGCTTTGAATACTTCGATGAGTGGCTAAAAACTGGGTTTGCCATTTCACAAAGACTCCCTCTTGAGGCTG
GCGCGTTTAGTTTTCCCACTCTGAATTATCCAACCTATAAAGGCCTACCTGCAGCCTTCGCAGATACTCTACCCGATGAC
TTTGGTAATGCCGTAATCAATGCCTGGCTTGCACGCCAGGGCCGAGACCCACAATCTTTCAGTGCATTGGAAAGACTGCT
CTATACCGGTTCACGAGGTATGGGAGCTCTTGAGTACACACCCGCATTAGCTGACACGAATAAAAAACAAGATGAATCAA
TTAAACTCGACTCACTTGTAGCAATGGCACAACTCGTCCTTGACGAAAGAAACAACCTAGATGAAACCATCATCAATGAG
CAGGAAGCGGAGCAAGCCTTAACTGGCATCCTTCAAGTCGGCACCTCAGCTGGCGGTGCTAGAGCTAAAGCGGTTATCGC
AGTCAACTCAGATCGCACGCAAATACGCTCAGGTCAGGTAAATGCTCCCAAAGGCTTCGAACACTTCCTATTAAAGTTTG
ATGGCGTTGTCGAACGCTCATCCACTAGTGAGGTATTTGGTGATCCTAAAGGCTTCGGCTTAATGGAATATGCCTATTAC
TTAATGGCCAAAAAAGCCGGCATCAATATCTCACATTGTGAATTATTAAAAGAAAACGGGCGTGCTCACTTCATGACAAA
ACGATTTGACCGCGTTGGAAACGAAAAAGTGCATTATCAATCTTTATGCGCTATGGATCACGCAGATTTCAAACAACCTG
GCGGTTACAGTTATGAAGAACTCTTCACCCTATTGCGCTCACTGAGACTTGATCGACTATCAGCACTTGAAGTGTTTAGA
CGCATGGCCTTTAACGTGATTGCCCGCAACCACGATGACCACACAAAAAACTGGGGATTCGTTATCAATAGTACGAACAA
GTGGGAACTCGCGCCAGCATTCGATCTAGCATATAGCTACAAACCCGGCTCGCCTTGGGTAGAGAGCCATCAAATGTCGA
TCAACGGTAAGCGAGACAATTTTACCAAACAAGACTTACTAGGAGTCGTACCTCCATCACTACAAGGTGAGGCAGAAGCT
ATTTTAAGTGAGGTTCATGCCACCGTGACAACATGGCGAGAAATAGCAAGAGACGTAGGTGTCGAACCATCGTTCCTTGA
TGAAATAGAGTCCAACCACAGACTCAACCTAGTATGA
TTGGTAGGCAAGAAATACGACACAGCAAAAGTCAGTATATTCGGTAAAGATGTCGGCGCTCTAGCTGAAGATACTACGAC
CGGAATCGTTAGCTTTGAATACTTCGATGAGTGGCTAAAAACTGGGTTTGCCATTTCACAAAGACTCCCTCTTGAGGCTG
GCGCGTTTAGTTTTCCCACTCTGAATTATCCAACCTATAAAGGCCTACCTGCAGCCTTCGCAGATACTCTACCCGATGAC
TTTGGTAATGCCGTAATCAATGCCTGGCTTGCACGCCAGGGCCGAGACCCACAATCTTTCAGTGCATTGGAAAGACTGCT
CTATACCGGTTCACGAGGTATGGGAGCTCTTGAGTACACACCCGCATTAGCTGACACGAATAAAAAACAAGATGAATCAA
TTAAACTCGACTCACTTGTAGCAATGGCACAACTCGTCCTTGACGAAAGAAACAACCTAGATGAAACCATCATCAATGAG
CAGGAAGCGGAGCAAGCCTTAACTGGCATCCTTCAAGTCGGCACCTCAGCTGGCGGTGCTAGAGCTAAAGCGGTTATCGC
AGTCAACTCAGATCGCACGCAAATACGCTCAGGTCAGGTAAATGCTCCCAAAGGCTTCGAACACTTCCTATTAAAGTTTG
ATGGCGTTGTCGAACGCTCATCCACTAGTGAGGTATTTGGTGATCCTAAAGGCTTCGGCTTAATGGAATATGCCTATTAC
TTAATGGCCAAAAAAGCCGGCATCAATATCTCACATTGTGAATTATTAAAAGAAAACGGGCGTGCTCACTTCATGACAAA
ACGATTTGACCGCGTTGGAAACGAAAAAGTGCATTATCAATCTTTATGCGCTATGGATCACGCAGATTTCAAACAACCTG
GCGGTTACAGTTATGAAGAACTCTTCACCCTATTGCGCTCACTGAGACTTGATCGACTATCAGCACTTGAAGTGTTTAGA
CGCATGGCCTTTAACGTGATTGCCCGCAACCACGATGACCACACAAAAAACTGGGGATTCGTTATCAATAGTACGAACAA
GTGGGAACTCGCGCCAGCATTCGATCTAGCATATAGCTACAAACCCGGCTCGCCTTGGGTAGAGAGCCATCAAATGTCGA
TCAACGGTAAGCGAGACAATTTTACCAAACAAGACTTACTAGGAGTCGTACCTCCATCACTACAAGGTGAGGCAGAAGCT
ATTTTAAGTGAGGTTCATGCCACCGTGACAACATGGCGAGAAATAGCAAGAGACGTAGGTGTCGAACCATCGTTCCTTGA
TGAAATAGAGTCCAACCACAGACTCAACCTAGTATGA
Antitoxin
Download Length: 116 a.a. Molecular weight: 13075.17 Da Isoelectric Point: 10.5772
>AT40328 WP_225998621.1 NZ_AP025501:c50594-50247 [Vibrio lentus]
MKSNIYAMSDEALISELGRRIERRRLDHRSSLTQAQLAKKAGISRSTYQNMIEGRSTLINVIKVLRVLDSLEGIESFLPD
PGISPVQLLKMKGKVRQRVKLASTPQQPKEEDLDW
MKSNIYAMSDEALISELGRRIERRRLDHRSSLTQAQLAKKAGISRSTYQNMIEGRSTLINVIKVLRVLDSLEGIESFLPD
PGISPVQLLKMKGKVRQRVKLASTPQQPKEEDLDW
Download Length: 348 bp
>AT40328 NZ_AP025501:c50594-50247 [Vibrio lentus]
ATGAAGTCGAATATATACGCAATGTCAGATGAAGCACTGATCAGTGAACTTGGCCGTCGAATCGAAAGACGAAGGCTCGA
TCACCGTTCGTCACTTACTCAAGCACAGTTAGCTAAAAAGGCCGGAATCAGCCGGTCAACATACCAAAATATGATAGAGG
GTAGATCAACCCTAATAAACGTCATCAAGGTACTCAGAGTGTTAGATTCATTGGAAGGCATTGAATCTTTCCTACCAGAC
CCTGGAATTAGCCCAGTACAACTTCTCAAAATGAAAGGGAAAGTACGCCAAAGGGTAAAGCTGGCCTCAACGCCACAACA
ACCTAAAGAGGAGGACTTAGATTGGTAG
ATGAAGTCGAATATATACGCAATGTCAGATGAAGCACTGATCAGTGAACTTGGCCGTCGAATCGAAAGACGAAGGCTCGA
TCACCGTTCGTCACTTACTCAAGCACAGTTAGCTAAAAAGGCCGGAATCAGCCGGTCAACATACCAAAATATGATAGAGG
GTAGATCAACCCTAATAAACGTCATCAAGGTACTCAGAGTGTTAGATTCATTGGAAGGCATTGAATCTTTCCTACCAGAC
CCTGGAATTAGCCCAGTACAACTTCTCAAAATGAAAGGGAAAGTACGCCAAAGGGTAAAGCTGGCCTCAACGCCACAACA
ACCTAAAGAGGAGGACTTAGATTGGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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