Detailed information of TA system TA040326

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /ElaA-DUF1778
• Location: 5992..6755
• Replicon: plasmid p1
• Accession: NZ_AP025501
• Organism: Vibrio lentus strain LMG 21034

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: OCV49_RS25235
• Protein ID: WP_192854472.1
• Coordinates: 5992..6486 (-)
• Length: 165 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: OCV49_RS25240
• Protein ID: WP_192854474.1
• Coordinates: 6483..6755 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV49_RS25225	1489..3315	+	1827	WP_192854469.1	ABC transporter ATP-binding protein	-
OCV49_RS25230	3308..5086	+	1779	WP_192854471.1	ABC transporter ATP-binding protein	-
OCV49_RS25235	5992..6486	-	495	WP_192854472.1	GNAT family N-acetyltransferase	Toxin
OCV49_RS25240	6483..6755	-	273	WP_192854474.1	DUF1778 domain-containing protein	Antitoxin
OCV49_RS25245	7351..8322	+	972	WP_192854475.1	amino acid--tRNA ligase-related protein	-
OCV49_RS25250	8869..9225	+	357	WP_192854477.1	IS66 family insertion sequence element accessory protein TnpB	-
OCV49_RS25255	9282..9794	+	513	WP_225998601.1	hypothetical protein	-
OCV49_RS25260	9867..10205	+	339	WP_261891700.1	transposase	-
OCV49_RS25265	10843..11145	-	303	WP_048659320.1	HigA family addiction module antitoxin	-
OCV49_RS25270	11145..11249	-	105	Protein_10	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..251461	251461
	-	flank	IS/Tn	-	-	8869..9225	356

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (81-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (2-87)

Sequences

Toxin

Protein

• Length: 165 a.a.
• Molecular weight: 18289.82 Da
• Isoelectric Point: 8.8120

>T40326 WP_192854472.1 NZ_AP025501:c6486-5992 [Vibrio lentus]
MNTVLLDKAKHDRNRFNCGIEALNNYLKVMASQQAKKDNTRTFVLEDDNDNSHIIGFYTLTMTQIDLKALPGKLQKKHQS
STSGGLIARLAVDDRYKGNGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKNFYDRYGFQAFQDAENKLFITIADVR
ASLG

Nucleotide

• Length: 495 bp

>T40326 NZ_AP025501:c6486-5992 [Vibrio lentus]
ATGAATACGGTACTTCTAGATAAAGCTAAACACGATAGAAACCGTTTCAACTGTGGCATCGAAGCTCTCAATAATTACTT
AAAAGTAATGGCGAGTCAGCAAGCAAAGAAAGACAATACCAGAACGTTTGTTTTGGAAGATGATAACGACAACTCGCATA
TCATCGGCTTTTACACGCTAACAATGACACAAATTGACTTAAAGGCATTACCCGGTAAGTTACAAAAGAAGCACCAATCA
TCGACTTCTGGTGGTCTCATTGCTCGTCTTGCTGTCGATGACCGATACAAAGGGAACGGCTTTGGTGAGTGGCTGCTTAT
TGACGCGCTCCGAAAGCTATTAGCAGCTAGTGATAGCGTTGCGTTTCCAGTTGTTATCGTCGATGCCAAAGACGGTGCAA
AAAATTTCTATGATCGTTATGGCTTTCAAGCATTTCAGGACGCTGAAAACAAACTATTCATTACCATTGCAGATGTTAGA
GCAAGCTTAGGCTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9760.23 Da
• Isoelectric Point: 8.6190

>AT40326 WP_192854474.1 NZ_AP025501:c6755-6483 [Vibrio lentus]
MATTLPRITARVDVDTQDLLTKATAIAGMSSINSFVLSAAIEKAKQVIEREQALKLSQADAMLLMEALDHPATQNSKLKA
ASDRYESKAR

Nucleotide

• Length: 273 bp

>AT40326 NZ_AP025501:c6755-6483 [Vibrio lentus]
ATGGCTACTACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACACAAGATTTACTTACTAAAGCTACCGCGATCGC
TGGTATGTCTAGTATTAACTCATTTGTTCTAAGTGCTGCAATTGAAAAGGCTAAACAAGTCATTGAACGTGAACAGGCTT
TAAAACTGAGCCAAGCTGATGCTATGTTGCTAATGGAAGCTTTGGACCATCCTGCAACGCAGAATTCAAAACTAAAAGCT
GCCTCTGATCGATACGAGAGTAAGGCTCGATGA