Detailed information of TA system TA040325

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2526315..2526859
• Replicon: chromosome
• Accession: NZ_AP025499
• Organism: Vibrio lentus strain LMG 21034

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: OCV49_RS11715
• Protein ID: WP_192854322.1
• Coordinates: 2526554..2526859 (+)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: OCV49_RS11710
• Protein ID: WP_171342103.1
• Coordinates: 2526315..2526557 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV49_RS11685	2521749..2522114	+	366	WP_192854317.1	hypothetical protein	-
OCV49_RS11690	2522230..2523414	+	1185	WP_192854318.1	FIST N-terminal domain-containing protein	-
OCV49_RS11695	2523414..2525141	+	1728	WP_192854319.1	ATP-binding protein	-
OCV49_RS11700	2525588..2526010	+	423	WP_192854320.1	phage protein	-
OCV49_RS11705	2526025..2526201	+	177	WP_192854321.1	hypothetical protein	-
OCV49_RS11710	2526315..2526557	+	243	WP_171342103.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
OCV49_RS11715	2526554..2526859	+	306	WP_192854322.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV49_RS11720	2526943..2527902	-	960	WP_192854323.1	hypothetical protein	-
OCV49_RS11725	2528056..2529096	-	1041	WP_192854324.1	AAA family ATPase	-
OCV49_RS11730	2529093..2529461	-	369	WP_192854325.1	hypothetical protein	-
OCV49_RS11735	2529654..2530145	-	492	WP_261890930.1	toll/interleukin-1 receptor domain-containing protein	-
OCV49_RS11740	2530743..2531006	-	264	WP_192854327.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2526315..2551193	24878

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-92)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11880.77 Da
• Isoelectric Point: 10.7649

>T40325 WP_192854322.1 NZ_AP025499:2526554-2526859 [Vibrio lentus]
MTPFQLTNKAKADLRDIALFTERRWGRKQRNVYIRQFDTTFGRLAENPELGKTCDEIRPGYRKFPQASHVIFYQKTNNQP
LLIIRILHKSMDVLPIFGAQT

Nucleotide

• Length: 306 bp

>T40325 NZ_AP025499:2526554-2526859 [Vibrio lentus]
ATGACGCCTTTTCAGCTCACGAACAAGGCAAAGGCCGATCTTAGAGACATTGCCTTGTTTACTGAGCGTCGTTGGGGTCG
CAAGCAACGAAATGTCTATATCAGACAGTTCGATACCACATTTGGCCGCTTAGCGGAGAATCCGGAGCTTGGAAAAACCT
GTGATGAAATCAGGCCAGGTTACCGAAAATTCCCACAGGCCAGTCATGTCATTTTCTACCAGAAAACGAACAACCAACCT
CTCCTAATCATACGAATCTTACACAAAAGTATGGATGTACTTCCCATCTTTGGCGCACAAACTTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8981.93 Da
• Isoelectric Point: 4.3085

>AT40325 WP_171342103.1 NZ_AP025499:2526315-2526557 [Vibrio lentus]
MARNTSITLGEHFDGFIASQIQSGRYGSASEVIRSALRLLETQETKMNTLRQLLVEGENSGIADYDLDTFINELDSEERK

Nucleotide

• Length: 243 bp

>AT40325 NZ_AP025499:2526315-2526557 [Vibrio lentus]
ATGGCGAGAAATACAAGCATTACCTTGGGTGAACACTTTGATGGGTTTATTGCGAGCCAGATCCAAAGCGGTCGTTATGG
CTCAGCCAGCGAGGTGATCCGATCGGCGCTGCGTTTACTCGAAACCCAAGAGACGAAAATGAATACGTTACGACAGCTGC
TCGTGGAAGGTGAAAACAGTGGGATCGCGGATTACGACCTCGATACTTTCATTAATGAACTCGACAGTGAAGAAAGAAAA
TGA