Detailed information of TA system TA040324

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1917..2479
• Replicon: plasmid p2
• Accession: NZ_AP025486
• Organism: Vibrio echinoideorum strain DSM 107264

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: OCV36_RS25285
• Protein ID: WP_135459111.1
• Coordinates: 1917..2219 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: OCV36_RS25290
• Protein ID: WP_135459109.1
• Coordinates: 2219..2479 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV36_RS25275	250..1164	+	915	WP_135459116.1	AAA family ATPase	-
OCV36_RS25280	1302..1913	+	612	WP_135459113.1	recombinase family protein	-
OCV36_RS25285	1917..2219	-	303	WP_135459111.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV36_RS25290	2219..2479	-	261	WP_135459109.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCV36_RS25295	2697..3236	+	540	WP_135459107.1	recombinase family protein	-
OCV36_RS25300	4029..4238	-	210	WP_245300945.1	hypothetical protein	-
OCV36_RS25305	4527..5492	-	966	WP_135459105.1	WYL domain-containing protein	-
OCV36_RS25310	5714..5908	+	195	WP_135459103.1	hypothetical protein	-
OCV36_RS25315	6276..6698	+	423	WP_135459102.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	bauB	1..45679	45679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-57)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11797.60 Da
• Isoelectric Point: 9.3084

>T40324 WP_135459111.1 NZ_AP025486:c2219-1917 [Vibrio echinoideorum]
MMHYKLSSAAQSDLIEIRRYTLERWGQTQWTTYFSELKQSMELLANNQLLGIEVSELGQNYFRFPLKHHVIYYIQKQEHI
VIAAVLGKHMSPAKHFSQLS

Nucleotide

• Length: 303 bp

>T40324 NZ_AP025486:c2219-1917 [Vibrio echinoideorum]
ATGATGCACTACAAGCTTTCTTCTGCAGCGCAATCTGATCTCATTGAGATTCGTCGCTATACATTAGAGCGATGGGGGCA
AACACAATGGACGACTTACTTTTCAGAGCTCAAGCAATCAATGGAATTACTGGCGAACAACCAGCTGCTTGGCATAGAAG
TTTCTGAACTGGGCCAAAATTACTTCCGGTTTCCTTTAAAGCACCATGTGATTTATTACATCCAAAAACAAGAGCACATC
GTTATTGCAGCCGTTCTTGGTAAGCACATGTCGCCTGCCAAGCACTTTTCACAACTCTCTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9601.01 Da
• Isoelectric Point: 4.5556

>AT40324 WP_135459109.1 NZ_AP025486:c2479-2219 [Vibrio echinoideorum]
MQSLTANTAKTKFGDLLMKVQREPVQIKKNGSPVAVMMSCEEYEQLEALKLMVVKSRFEQAEADALSDNLVDGNDFMNAL
NQGKFD

Nucleotide

• Length: 261 bp

>AT40324 NZ_AP025486:c2479-2219 [Vibrio echinoideorum]
ATGCAATCACTTACTGCTAATACAGCTAAAACCAAATTTGGTGACTTACTGATGAAGGTTCAACGTGAACCTGTACAAAT
TAAAAAGAACGGTTCACCCGTTGCGGTGATGATGTCTTGTGAAGAATATGAACAACTTGAAGCACTCAAATTGATGGTGG
TGAAATCACGATTCGAACAAGCAGAGGCCGATGCTCTATCAGATAACCTGGTCGACGGTAACGACTTCATGAACGCACTT
AACCAAGGTAAATTTGATTAA