Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3303930..3305764 Replicon chromosome
Accession NZ_AP025483
Organism Vibrio echinoideorum strain DSM 107264

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OCV36_RS14960 Protein ID WP_167853017.1
Coordinates 3303930..3305291 (+) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OCV36_RS14965 Protein ID WP_135455618.1
Coordinates 3305276..3305764 (+) Length 163 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV36_RS14935 3301134..3301469 + 336 WP_135455609.1 hypothetical protein -
OCV36_RS14940 3301466..3302695 + 1230 WP_135455610.1 hypothetical protein -
OCV36_RS14945 3302722..3302853 - 132 WP_261887525.1 hypothetical protein -
OCV36_RS14950 3302882..3303208 + 327 WP_135455612.1 type II toxin-antitoxin system RelE/ParE family toxin -
OCV36_RS14955 3303195..3303509 + 315 WP_135455613.1 DNA-binding transcriptional regulator -
OCV36_RS14960 3303930..3305291 + 1362 WP_167853017.1 HipA domain-containing protein Toxin
OCV36_RS14965 3305276..3305764 + 489 WP_135455618.1 helix-turn-helix transcriptional regulator Antitoxin
OCV36_RS14970 3306186..3307349 + 1164 WP_135455620.1 DUF3596 domain-containing protein -
OCV36_RS14975 3307346..3308056 + 711 WP_245300914.1 hypothetical protein -
OCV36_RS14980 3308160..3308405 + 246 WP_135455622.1 type II toxin-antitoxin system CcdA family antitoxin -
OCV36_RS14985 3308405..3308722 + 318 WP_135455624.1 CcdB family protein -
OCV36_RS14990 3309072..3309626 - 555 WP_135455626.1 GTP pyrophosphokinase -
OCV36_RS14995 3309914..3310192 - 279 WP_135455628.1 type II toxin-antitoxin system RelE/ParE family toxin -
OCV36_RS15000 3310189..3310473 - 285 WP_167853018.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(166-397)

Antitoxin

Cro/C1-type helix-turn-helix domain

(87-140)


Sequences

Toxin        


Download         Length: 454 a.a.        Molecular weight: 51552.36 Da        Isoelectric Point: 4.8632

>T40321 WP_167853017.1 NZ_AP025483:3303930-3305291 [Vibrio echinoideorum]
MEELTVQAFIKGEWLDVALISFPKSAQHNFQISELNYLSDYALYHHDKDDLHAVSINHPVSFFFDDMGKPGWLRFLDDIM
PSGASRRYWVKHLDIEDLSFDEQDFVLLKFGTMSPIGNLRVKESLPERYEISDNLYFSVEDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLLLRSEITPHTGDEKIWIDPYQDDPSNHDLHYLVKYPRGSRSTVDCNILRAEFYYYHALTEMGFDTIP
IQGMRLEEGLNYPSLWLPRFDIQINKEQVEKFGMESVYSMLNKGAGVTLNHEATIRSLIEKMTQSHMVQHQGYAFDPQEF
VVEWVKRDLLNILFGNSDNHGRNTSFLRGDGFIKLAPIYDFAPMKADPEGIPRSTKWQAPLEVGGTYDFIGIAESLSDLV
PTAVLLEELRDTAAKCLDLKKRLEEQGVPKQILEMPAIGFNHISEKLTKWGLA

Download         Length: 1362 bp

>T40321 NZ_AP025483:3303930-3305291 [Vibrio echinoideorum]
ATGGAAGAATTAACAGTACAAGCTTTTATCAAAGGTGAATGGCTCGATGTTGCTCTCATCTCATTCCCTAAGAGTGCTCA
GCATAACTTCCAAATTTCTGAACTCAATTATCTCAGTGATTATGCTCTCTATCATCATGATAAAGACGATTTGCATGCAG
TTTCGATCAATCACCCTGTTTCTTTTTTCTTTGATGATATGGGAAAACCTGGTTGGTTAAGATTCCTAGACGACATAATG
CCAAGTGGTGCTAGTAGAAGGTACTGGGTCAAGCACTTAGATATTGAGGATCTAAGCTTCGATGAACAAGACTTTGTTTT
ACTTAAGTTTGGGACGATGTCGCCTATCGGCAATTTACGGGTGAAAGAGTCTCTTCCTGAGCGTTACGAAATATCAGACA
ACCTCTATTTCTCTGTTGAGGATGTTAAGAACCGAGCGGGTGATTTCCTCGACTATGCACAGCAAAGAGGCGCAGCGGCA
GGTGGAGCGACGGGCGCGGGAGGAGAGGCCCCTAAATTACTCCTACGTAGCGAGATAACCCCTCACACTGGCGACGAAAA
AATATGGATAGATCCCTATCAAGATGACCCTAGCAATCACGATTTACACTACCTGGTAAAATACCCCAGAGGTTCGAGAA
GCACCGTCGACTGTAATATTCTAAGAGCTGAGTTCTATTACTATCATGCACTTACTGAAATGGGTTTTGATACGATTCCA
ATACAAGGCATGCGCTTAGAAGAAGGTCTTAATTACCCTTCGTTATGGCTACCTAGATTTGATATTCAAATCAATAAGGA
ACAGGTGGAAAAATTCGGTATGGAATCCGTATACTCCATGCTAAATAAAGGTGCAGGAGTCACTCTCAACCACGAAGCCA
CTATCAGAAGCCTCATAGAAAAGATGACCCAAAGCCACATGGTTCAACATCAAGGGTATGCTTTCGACCCCCAGGAGTTC
GTCGTTGAGTGGGTAAAGCGAGATTTACTCAATATCTTGTTTGGGAATAGTGACAACCACGGAAGAAATACTTCCTTCCT
GAGAGGGGACGGTTTTATTAAGCTGGCTCCTATATACGACTTTGCACCAATGAAAGCCGATCCCGAGGGCATTCCAAGAA
GCACAAAATGGCAAGCACCACTCGAAGTCGGCGGAACCTATGATTTTATAGGAATAGCTGAATCCCTGTCAGATCTAGTA
CCAACAGCCGTCCTTCTTGAAGAACTAAGAGATACAGCCGCTAAATGCCTTGACCTTAAAAAGAGACTGGAAGAACAAGG
TGTACCAAAACAAATCTTGGAGATGCCAGCAATTGGGTTTAATCATATATCTGAAAAATTGACAAAATGGGGGCTAGCAT
GA

Antitoxin


Download         Length: 163 a.a.        Molecular weight: 17771.38 Da        Isoelectric Point: 11.0377

>AT40321 WP_135455618.1 NZ_AP025483:3305276-3305764 [Vibrio echinoideorum]
MGASMSKSSRSNKETVHETVARLRASREQPKSIASHQPTHSGKSKLQPNTQAKQKVSKNSKAIRASDRKTAMDDIIKQLL
LGGLTQGQALRTLRVNILGLKQDVFAKLVDVSRKTLSDIENDRGSYNTEVLNKVFKPFGMKTGLIPSSPSLLISLLNSNE
TE

Download         Length: 489 bp

>AT40321 NZ_AP025483:3305276-3305764 [Vibrio echinoideorum]
ATGGGGGCTAGCATGAGTAAGAGTAGCCGATCAAATAAAGAGACTGTACATGAGACCGTAGCTCGCCTAAGAGCAAGCCG
AGAACAGCCAAAGTCAATAGCTTCCCATCAACCAACACACTCGGGAAAGAGTAAATTACAACCAAATACTCAAGCAAAAC
AGAAGGTATCTAAGAACTCAAAAGCGATCAGGGCATCTGATCGTAAAACGGCTATGGACGATATTATCAAACAACTCTTG
CTTGGTGGGCTCACACAAGGCCAAGCCCTTAGAACACTGCGAGTGAACATACTAGGCCTAAAACAGGATGTTTTTGCAAA
ACTCGTCGATGTCTCAAGAAAAACACTCTCAGATATTGAGAATGATAGAGGTAGCTACAACACCGAGGTTCTAAACAAAG
TATTCAAACCTTTTGGTATGAAAACGGGGTTAATTCCCTCATCGCCGAGTTTACTCATTTCTCTATTAAACAGTAACGAG
ACAGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References