Detailed information of TA system TA040319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 39996..40549
• Replicon: plasmid pLMG21359
• Accession: NZ_AP025482
• Organism: Vibrio cyclitrophicus strain LMG 21359

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: OCW38_RS22585
• Protein ID: WP_046209588.1
• Coordinates: 39996..40289 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: OCW38_RS22590
• Protein ID: WP_261896626.1
• Coordinates: 40286..40549 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCW38_RS22570	36155..37245	+	1091	Protein_33	agmatine deiminase	-
OCW38_RS22575	38006..39031	+	1026	WP_046209586.1	hypothetical protein	-
OCW38_RS22580	39028..39942	+	915	WP_146493144.1	AAA family ATPase	-
OCW38_RS22585	39996..40289	-	294	WP_046209588.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCW38_RS22590	40286..40549	-	264	WP_261896626.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCW38_RS22595	40725..41275	+	551	Protein_38	IS3 family transposase	-
OCW38_RS22600	41330..41919	-	590	Protein_39	integrase core domain-containing protein	-
OCW38_RS22605	42012..42529	-	518	Protein_40	integrase core domain-containing protein	-
OCW38_RS22610	42760..43353	+	594	WP_146493142.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..134644	134644
	-	flank	IS/Tn	-	-	40725..40856	131

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-63)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11521.38 Da
• Isoelectric Point: 10.2043

>T40319 WP_046209588.1 NZ_AP025482:c40289-39996 [Vibrio cyclitrophicus]
MKQYKLSSAAQSDLIEIRRYTLERWGKTQWTTYFSELKQSMELLANNQLLGIAFFELGQNYFRFPLKHHVIYYIQKRDHI
VIAAVLGKHMSPAKHFS

Nucleotide

• Length: 294 bp

>T40319 NZ_AP025482:c40289-39996 [Vibrio cyclitrophicus]
ATGAAGCAATATAAGCTTTCTTCTGCAGCGCAATCGGATCTCATTGAGATTCGTCGCTATACTTTAGAGCGATGGGGGAA
AACACAATGGACAACTTACTTCTCAGAGCTAAAGCAATCTATGGAATTACTGGCTAACAACCAGCTACTCGGCATAGCTT
TTTTTGAGCTAGGCCAAAACTATTTCCGGTTTCCTTTAAAGCATCATGTGATTTATTACATCCAAAAGCGAGATCACATT
GTTATTGCTGCCGTGCTTGGTAAGCACATGTCTCCGGCCAAGCACTTTTCATAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9656.13 Da
• Isoelectric Point: 4.7405

>AT40319 WP_261896626.1 NZ_AP025482:c40549-40286 [Vibrio cyclitrophicus]
MQSLTANTAKTKFGGLLMKVQREPIQINKNGSPVAVMMSCEEYEQLEALKLMVIKSRFEQAEADALSDNLVDGNDFMNVL
GQGKFDK

Nucleotide

• Length: 264 bp

>AT40319 NZ_AP025482:c40549-40286 [Vibrio cyclitrophicus]
ATGCAATCACTTACTGCTAATACAGCTAAAACCAAATTTGGTGGCTTATTAATGAAGGTTCAACGTGAACCTATACAAAT
TAATAAAAATGGTTCACCCGTTGCGGTGATGATGTCTTGTGAGGAATACGAACAACTTGAAGCATTGAAATTGATGGTGA
TAAAATCACGCTTCGAACAAGCTGAAGCTGACGCTCTATCAGATAACCTAGTCGACGGTAATGATTTCATGAACGTACTT
GGCCAAGGTAAATTTGATAAATGA