Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TacT2-ataR/DUF1778(antitoxin)
Location 3126029..3126795 Replicon chromosome
Accession NZ_AP025480
Organism Vibrio cyclitrophicus strain LMG 21359

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag OCW38_RS13725 Protein ID WP_261894498.1
Coordinates 3126029..3126538 (-) Length 170 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag OCW38_RS13730 Protein ID WP_261894500.1
Coordinates 3126529..3126795 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCW38_RS13705 3122607..3122654 + 48 Protein_2593 DNA-binding protein -
OCW38_RS13710 3122908..3123420 + 513 WP_261894493.1 DUF2442 domain-containing protein -
OCW38_RS13715 3123536..3124891 - 1356 WP_065100529.1 Fic family protein -
OCW38_RS13720 3125575..3125841 - 267 WP_261894496.1 hypothetical protein -
OCW38_RS13725 3126029..3126538 - 510 WP_261894498.1 GNAT family N-acetyltransferase Toxin
OCW38_RS13730 3126529..3126795 - 267 WP_261894500.1 DUF1778 domain-containing protein Antitoxin
OCW38_RS13735 3127009..3128151 + 1143 WP_261894502.1 transposase -
OCW38_RS13740 3128556..3128864 - 309 WP_261894504.1 hypothetical protein -
OCW38_RS13745 3128977..3129810 + 834 WP_102397595.1 hypothetical protein -
OCW38_RS13750 3129791..3129967 + 177 Protein_2602 IS1634 family transposase -
OCW38_RS13755 3130221..3130685 + 465 WP_261894507.1 hypothetical protein -
OCW38_RS13760 3130756..3131694 - 939 WP_261894509.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3127009..3128151 1142


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-146)

Antitoxin

Vibrio phage ICP1, Orf50

(8-83)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18367.34 Da        Isoelectric Point: 8.4684

>T40318 WP_261894498.1 NZ_AP025480:c3126538-3126029 [Vibrio cyclitrophicus]
MGLVKPRLLIGSDLTSSFHCGVESLDLWLKKQALKSQNRGNTKTYVVTDSDTNAVVGYYAIAMGSVSRDIAFSALKRNSP
DPIPMVVLARLAVDLKYQGKHVAIGLLKDCILRSMAAMEVVGGAGILIHALDDNAQSFYKRFGFKESSIDSLVLMARISD
LTESLTLET

Download         Length: 510 bp

>T40318 NZ_AP025480:c3126538-3126029 [Vibrio cyclitrophicus]
TTGGGATTAGTTAAACCTCGTTTATTAATAGGTAGTGATCTCACGAGTTCTTTTCACTGTGGTGTTGAGTCCTTAGATCT
GTGGCTTAAGAAACAAGCGCTAAAAAGTCAAAACCGTGGTAATACGAAAACTTATGTCGTCACTGATTCAGATACGAATG
CTGTAGTGGGATACTACGCTATCGCGATGGGGTCAGTATCAAGAGATATTGCTTTTAGTGCTTTAAAACGAAATAGCCCA
GACCCAATACCAATGGTGGTATTAGCAAGGCTGGCCGTTGATTTGAAATATCAGGGCAAACACGTTGCGATTGGTTTGCT
TAAAGACTGTATTTTGCGCTCCATGGCAGCAATGGAAGTGGTCGGTGGAGCAGGTATATTAATTCATGCTTTGGACGATA
ATGCACAGTCCTTCTATAAACGGTTTGGCTTTAAAGAATCGAGCATCGATAGTTTGGTGTTGATGGCGAGAATCAGTGAT
TTAACAGAATCACTTACGCTGGAAACGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9945.34 Da        Isoelectric Point: 4.5917

>AT40318 WP_261894500.1 NZ_AP025480:c3126795-3126529 [Vibrio cyclitrophicus]
MATKSAPINMRVFPSVRDVIDAAANLQKVDRTVFIQQAALNEAQKVLADQKDFKLEQDAFDAFEQALDEPPKVLKGIQDL
FERKAPWD

Download         Length: 267 bp

>AT40318 NZ_AP025480:c3126795-3126529 [Vibrio cyclitrophicus]
ATGGCTACTAAATCAGCCCCGATCAATATGCGCGTATTCCCCTCCGTCCGTGATGTTATTGACGCAGCAGCAAACCTACA
GAAAGTGGATAGAACCGTATTTATTCAGCAAGCCGCTTTGAATGAAGCTCAAAAAGTACTGGCAGATCAGAAAGACTTCA
AATTAGAACAAGACGCATTTGACGCATTTGAACAAGCGCTTGATGAGCCACCTAAAGTTCTTAAAGGTATTCAAGATTTA
TTCGAAAGGAAGGCACCTTGGGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References