Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 124076..124638 Replicon plasmid p1
Accession NZ_AP025478
Organism Vibrio crassostreae strain LMG 22240

Toxin (Protein)


Gene name parE Uniprot ID A0A1B1C333
Locus tag OC193_RS24830 Protein ID WP_017061973.1
Coordinates 124076..124378 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1B1C393
Locus tag OC193_RS24835 Protein ID WP_017061972.1
Coordinates 124378..124638 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OC193_RS24810 119650..119772 - 123 WP_259739813.1 hypothetical protein -
OC193_RS24815 121481..122506 + 1026 WP_048660681.1 hypothetical protein -
OC193_RS24820 122503..123417 + 915 WP_048660680.1 AAA family ATPase -
OC193_RS24825 123599..124072 + 474 WP_230690977.1 recombinase family protein -
OC193_RS24830 124076..124378 - 303 WP_017061973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OC193_RS24835 124378..124638 - 261 WP_017061972.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OC193_RS24840 124854..125411 + 558 WP_048659321.1 recombinase family protein -
OC193_RS24845 125583..125903 + 321 WP_080967496.1 type II toxin-antitoxin system RelE/ParE family toxin -
OC193_RS24850 125993..126292 + 300 WP_048659322.1 HigA family addiction module antitoxin -
OC193_RS24855 126461..127147 + 687 WP_048659323.1 IS6 family transposase -
OC193_RS24860 127722..128069 - 348 WP_230682258.1 hypothetical protein -
OC193_RS24865 128069..128257 - 189 WP_048659324.1 hypothetical protein -
OC193_RS24870 128374..128610 + 237 WP_048659326.1 hypothetical protein -
OC193_RS24875 128621..128794 + 174 WP_162200897.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..237546 237546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-57)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11782.63 Da        Isoelectric Point: 9.8778

>T40316 WP_017061973.1 NZ_AP025478:c124378-124076 [Vibrio crassostreae]
MMHYKLSSAAQSDLIEIRRYTLERWGQTQWTTYFSELKQSMELLANNQLLGIEVSELGKNYFRFPLKHHVIYYIQKQNHI
VIAAVLGKHMSPAKHFSQLS

Download         Length: 303 bp

>T40316 NZ_AP025478:c124378-124076 [Vibrio crassostreae]
ATGATGCACTACAAGCTTTCTTCTGCAGCGCAATCTGATCTCATTGAGATTCGTCGCTATACATTAGAGCGATGGGGGCA
AACACAATGGACGACTTACTTTTCAGAGCTCAAGCAATCAATGGAATTACTGGCGAACAACCAGCTGCTTGGCATAGAAG
TTTCTGAACTGGGAAAAAACTACTTCCGGTTTCCTTTAAAGCACCATGTGATTTATTACATCCAAAAGCAAAATCACATT
GTGATTGCAGCCGTTCTTGGTAAGCACATGTCACCTGCCAAGCACTTTTCACAACTCTCTTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9586.94 Da        Isoelectric Point: 4.3867

>AT40316 WP_017061972.1 NZ_AP025478:c124638-124378 [Vibrio crassostreae]
MQSLTANTAKTKFGDLLMKVQREPVQINKNGSPVAVMMSCEEYEQLEALKLMVVKSRFEQAEADALSDNLVDGNDFMNAL
NQGKFD

Download         Length: 261 bp

>AT40316 NZ_AP025478:c124638-124378 [Vibrio crassostreae]
ATGCAATCACTTACTGCTAATACAGCTAAAACCAAATTTGGTGACTTACTGATGAAGGTTCAACGTGAACCTGTACAAAT
TAATAAGAACGGTTCACCCGTTGCGGTGATGATGTCTTGTGAAGAATATGAACAACTTGAAGCACTCAAATTGATGGTGG
TGAAATCACGCTTCGAACAAGCAGAGGCCGATGCTCTATCAGATAACCTGGTCGACGGTAACGACTTCATGAACGCACTT
AACCAAGGTAAATTTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B1C333

Antitoxin

Source ID Structure
AlphaFold DB A0A1B1C393

References