Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 726597..728161 Replicon chromosome
Accession NZ_AP025476
Organism Vibrio crassostreae strain LMG 22240

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OC193_RS03365 Protein ID WP_048658807.1
Coordinates 726597..727913 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OC193_RS03370 Protein ID WP_017110259.1
Coordinates 727913..728161 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OC193_RS03350 722667..723395 + 729 WP_048663715.1 DUF429 domain-containing protein -
OC193_RS03355 723477..724286 + 810 WP_048663714.1 M15 family metallopeptidase -
OC193_RS03360 724592..726472 + 1881 WP_048663713.1 RimK/LysX family protein -
OC193_RS03365 726597..727913 - 1317 WP_048658807.1 type II toxin-antitoxin system HipA family toxin Toxin
OC193_RS03370 727913..728161 - 249 WP_017110259.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OC193_RS03375 728921..729769 - 849 WP_048666240.1 hypothetical protein -
OC193_RS03380 729976..731544 + 1569 WP_048666241.1 hypothetical protein -
OC193_RS03385 731741..732445 + 705 WP_048666242.1 inovirus Gp2 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-63)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49398.65 Da        Isoelectric Point: 7.5312

>T40314 WP_048658807.1 NZ_AP025476:c727913-726597 [Vibrio crassostreae]
MQQLNAYMNGELVGTLTKQNNGSHEFKYNESWLSNDKSRPLSLSLKLQIPTITSDAVINYFDNLLPDNIAIRNRIVARYQ
TASNQPFDLLKEIGKDSVGAIALLPPSQPYIENKLSYELLDESRLEKILAAHHSNIPLGMIKEEDDFRISVAGAQEKTAL
LRLNGDWCLPKGNTPTSHIIKLPIGEIKQPTSILDLTESVENEFICIELARELGFDVPTVEIITTHNYKAIAVERFDRRW
IKDRTHLLRLPQEDICQAKGIPSSIKYESDGGPGIADIMKLLEGSSNALEDRYNFMKFQVFQWAIGAIDGHAKNYSIFIE
KQGSYRLTPFYDILSAYPITGKKGLNIRKLKLAMGLKASRGKKYQISKIYSRHFLDTAHSVGFNSDSMQSILDDMQTELP
KAIERLAARLPEGFPKHITEAIFDNSIAMLNKLNLSKN

Download         Length: 1317 bp

>T40314 NZ_AP025476:c727913-726597 [Vibrio crassostreae]
ATGCAACAACTTAATGCCTACATGAATGGTGAGTTGGTCGGTACTCTCACAAAGCAAAACAATGGCTCTCACGAATTTAA
ATATAATGAGTCTTGGCTCAGTAACGACAAATCTCGCCCATTATCTTTATCCCTTAAACTACAAATACCTACGATAACTT
CTGATGCCGTTATCAACTACTTTGACAACCTGCTACCAGACAATATTGCTATACGTAATAGGATTGTTGCACGCTATCAA
ACGGCTTCAAATCAACCTTTTGATCTTCTGAAAGAAATTGGCAAAGACAGCGTTGGTGCCATTGCTCTGCTCCCTCCAAG
TCAACCCTATATCGAGAACAAACTGTCATACGAACTTCTTGACGAATCTCGGCTTGAAAAAATCTTAGCAGCCCATCATT
CCAATATTCCATTAGGTATGATTAAGGAAGAAGATGATTTCCGAATATCGGTTGCTGGCGCTCAAGAAAAAACAGCATTG
CTAAGGTTGAACGGAGATTGGTGTTTGCCTAAAGGGAATACACCTACAAGCCATATCATTAAGCTACCTATTGGTGAGAT
TAAGCAGCCCACATCTATTCTAGATCTGACTGAAAGTGTCGAGAATGAGTTCATCTGTATTGAGTTAGCTAGAGAGTTGG
GGTTTGATGTTCCGACCGTCGAGATCATCACAACCCATAATTATAAAGCCATTGCTGTTGAGCGTTTTGATAGACGTTGG
ATTAAGGATCGTACACACCTACTGCGCCTTCCTCAGGAAGATATCTGTCAAGCCAAAGGAATCCCTTCATCGATAAAATA
CGAAAGTGATGGAGGCCCCGGAATCGCCGATATTATGAAGCTACTTGAAGGCTCATCCAATGCACTGGAAGACAGATATA
ACTTCATGAAGTTTCAAGTTTTCCAATGGGCTATAGGCGCTATTGATGGGCATGCAAAGAACTATTCAATATTTATTGAA
AAGCAAGGTAGTTATCGCTTAACACCATTTTATGACATTTTGTCTGCTTACCCTATCACGGGGAAAAAAGGACTAAACAT
AAGAAAATTAAAGTTAGCAATGGGATTAAAAGCAAGTCGTGGTAAGAAGTACCAAATAAGCAAGATCTACTCTCGCCACT
TTCTTGATACAGCCCATTCAGTTGGCTTTAATTCTGATAGCATGCAAAGCATATTGGATGACATGCAAACTGAATTACCC
AAAGCAATTGAGCGCCTCGCCGCACGCTTGCCTGAAGGTTTCCCAAAACACATAACCGAAGCTATCTTTGATAACTCTAT
TGCCATGCTTAACAAATTGAATTTGAGCAAGAACTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9416.80 Da        Isoelectric Point: 9.7278

>AT40314 WP_017110259.1 NZ_AP025476:c728161-727913 [Vibrio crassostreae]
VIYSPQQLANTLLLIRQKNRWTQSELAKKVGIKQATISNFENRPEKATISTMFKLIQALDLTLKIEPKDAKNSQSTVDEE
DW

Download         Length: 249 bp

>AT40314 NZ_AP025476:c728161-727913 [Vibrio crassostreae]
GTGATTTATAGCCCACAACAATTAGCCAATACTTTACTGCTAATACGCCAAAAGAATAGGTGGACTCAGTCTGAGCTGGC
AAAAAAAGTAGGGATAAAACAAGCAACCATTTCGAACTTTGAAAATAGACCAGAAAAGGCAACTATTTCAACAATGTTCA
AGCTTATCCAAGCATTAGATCTCACCCTTAAAATCGAACCCAAAGATGCAAAAAATAGTCAAAGCACTGTTGATGAGGAA
GATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References