Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2418823..2420387 Replicon chromosome
Accession NZ_AP025472
Organism Vibrio cortegadensis strain CECT 7227

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OCV39_RS11430 Protein ID WP_136996125.1
Coordinates 2419071..2420387 (+) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag OCV39_RS11425 Protein ID WP_261888497.1
Coordinates 2418823..2419071 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OCV39_RS11395 2414310..2414951 - 642 WP_261888494.1 peptidase M15 -
OCV39_RS11400 2415294..2415521 - 228 WP_261888495.1 hypothetical protein -
OCV39_RS11405 2416296..2416964 + 669 WP_261888496.1 hypothetical protein -
OCV39_RS11410 2417271..2418002 + 732 Protein_2199 integrase arm-type DNA-binding domain-containing protein -
OCV39_RS11415 2418004..2418461 - 458 Protein_2200 transposase -
OCV39_RS11420 2418495..2418635 - 141 WP_240697194.1 hypothetical protein -
OCV39_RS11425 2418823..2419071 + 249 WP_261888497.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OCV39_RS11430 2419071..2420387 + 1317 WP_136996125.1 type II toxin-antitoxin system HipA family toxin Toxin
OCV39_RS11435 2420589..2421140 - 552 WP_261888498.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
OCV39_RS11440 2421437..2421868 + 432 WP_113796548.1 YccF domain-containing protein -
OCV39_RS11445 2422084..2424141 + 2058 WP_261889511.1 alpha-amylase family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2418177..2418461 284


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-63)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49534.84 Da        Isoelectric Point: 7.1615

>T40313 WP_136996125.1 NZ_AP025472:2419071-2420387 [Vibrio cortegadensis]
MQQLNAYMNGELVGTLIKQNNGSHEFQYNESWLSNDKSRPLSLSLKLQVPTITSDAVINYFDNLLPDNIAIRNRIVARYQ
TASNQPFDLLKEIGKDSVGAIALLQPNQPYIENKLSYELLDESRLEKILAAHHSDIPLGMIKEEDDFRISVAGAQEKTAL
LRLNETWCLPKGNTPTSHIIKLPIGEIKQPTSILDLTESVENEFICIELARELGFDVPKVEIITTHNYKAIAVERFDRRW
IKDRTQLLRLPQEDICQAKGIPSSIKYEIDGGPGIADIMKLLEGSSNALEDRYNFMKFQVFQWAIGAIDGHAKNYSIFIE
KQGSYRLTPFYDILSAYPITGKKGLNIRKLKLAMGLKASRGKKYQISKIYSRHFLDTANSVGFNSDSMQSILDDMQTELP
KAIERLAARLPEGFPKHITEAIFDNSIAMLNKLNLSKN

Download         Length: 1317 bp

>T40313 NZ_AP025472:2419071-2420387 [Vibrio cortegadensis]
ATGCAGCAACTTAATGCCTATATGAATGGTGAGTTAGTCGGTACCCTAATAAAACAAAACAATGGCTCTCATGAATTTCA
ATATAATGAGTCTTGGCTAAGTAACGACAAATCTCGCCCATTATCTTTATCTCTTAAACTACAAGTACCTACGATAACTT
CTGATGCCGTTATCAACTACTTCGACAACCTACTACCAGACAATATTGCTATACGTAATAGGATTGTTGCTCGCTATCAA
ACAGCTTCAAACCAGCCTTTTGATCTTCTAAAGGAAATTGGTAAAGACAGCGTAGGTGCCATTGCTCTGCTCCAACCAAA
TCAACCATATATCGAGAACAAACTATCATACGAACTTCTTGATGAATCTCGGCTTGAAAAAATCTTAGCTGCCCATCATT
CCGATATTCCATTAGGTATGATTAAGGAAGAAGATGACTTCCGAATATCTGTTGCTGGCGCTCAAGAAAAAACCGCATTA
CTAAGGTTGAATGAAACTTGGTGTTTGCCCAAAGGGAACACACCTACAAGCCATATCATTAAACTGCCTATTGGTGAAAT
TAAACAGCCCACCTCTATTTTAGATCTGACTGAAAGTGTCGAGAATGAGTTCATCTGTATTGAGTTAGCTAGAGAGCTGG
GGTTTGATGTTCCGAAAGTTGAGATCATCACAACCCATAATTATAAAGCCATTGCTGTTGAGCGCTTTGATAGACGTTGG
ATTAAGGATCGTACGCAACTATTGCGCCTTCCTCAGGAAGATATCTGTCAAGCTAAAGGGATCCCTTCATCTATAAAGTA
CGAAATTGATGGGGGACCAGGAATAGCCGATATTATGAAGCTACTTGAAGGCTCATCAAATGCACTGGAAGACAGATATA
ACTTCATGAAGTTTCAAGTTTTCCAATGGGCTATAGGCGCTATTGATGGGCATGCAAAGAACTATTCAATATTTATTGAA
AAGCAAGGTAGTTATCGTTTAACGCCTTTTTATGACATTTTGTCGGCTTACCCTATCACAGGAAAAAAAGGGCTGAACAT
CAGAAAGTTAAAGTTAGCAATGGGGTTAAAAGCAAGCCGTGGTAAGAAATACCAGATAAGCAAGATCTACTCTCGCCACT
TTCTTGATACCGCCAATTCAGTTGGCTTTAATTCTGATAGCATGCAAAGCATATTGGATGACATGCAAACTGAATTACCT
AAAGCAATTGAGCGCCTCGCTGCCCGCTTACCTGAAGGTTTCCCAAAACACATAACCGAAGCTATCTTTGATAACTCTAT
TGCTATGCTTAACAAATTAAATTTGAGCAAGAACTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9433.83 Da        Isoelectric Point: 9.6914

>AT40313 WP_261888497.1 NZ_AP025472:2418823-2419071 [Vibrio cortegadensis]
VIYSPQQLANTLLLIRQKNKWTQSELAKKVGIKQATISNFENRPEKATISTMFKLIQALELTLKIETKDAKNSQNTVDEE
DW

Download         Length: 249 bp

>AT40313 NZ_AP025472:2418823-2419071 [Vibrio cortegadensis]
GTGATTTATAGCCCACAACAATTAGCCAATACCTTACTGCTCATACGCCAAAAAAATAAGTGGACTCAATCTGAACTGGC
AAAAAAAGTAGGGATAAAACAAGCAACCATTTCGAACTTTGAAAATAGACCAGAAAAGGCAACTATTTCAACAATGTTCA
AGCTCATTCAAGCATTAGAACTCACTCTTAAAATCGAAACAAAAGATGCAAAAAACAGTCAAAATACTGTTGATGAGGAA
GATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References