Detailed information of TA system TA040311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-yefM/YoeB-RelB
• Location: 1340476..1340986
• Replicon: chromosome
• Accession: NZ_AP025472
• Organism: Vibrio cortegadensis strain CECT 7227

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: OCV39_RS06390
• Protein ID: WP_113795376.1
• Coordinates: 1340723..1340986 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: OCV39_RS06385
• Protein ID: WP_113795377.1
• Coordinates: 1340476..1340730 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV39_RS06345	1335537..1335761	+	225	WP_261889313.1	hypothetical protein	-
OCV39_RS06350	1335910..1336305	+	396	WP_261889314.1	DUF3465 domain-containing protein	-
OCV39_RS06355	1336340..1337296	-	957	WP_261889315.1	IS110 family transposase	-
OCV39_RS06360	1337706..1337999	+	294	WP_261889316.1	STAS domain-containing protein	-
OCV39_RS06365	1338156..1338515	+	360	WP_171757591.1	VOC family protein	-
OCV39_RS06370	1338654..1339046	+	393	WP_261889317.1	NUDIX domain-containing protein	-
OCV39_RS06375	1339202..1339636	+	435	WP_261889318.1	GNAT family N-acetyltransferase	-
OCV39_RS06380	1339801..1340268	+	468	WP_261889319.1	RDD family protein	-
OCV39_RS06385	1340476..1340730	+	255	WP_113795377.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
OCV39_RS06390	1340723..1340986	+	264	WP_113795376.1	Txe/YoeB family addiction module toxin	Toxin
OCV39_RS06395	1341197..1341802	+	606	WP_261889320.1	ATP-binding protein	-
OCV39_RS06400	1341904..1342386	+	483	WP_136996049.1	MazG-related protein	-
OCV39_RS06405	1343107..1343589	+	483	WP_261889321.1	MazG-related protein	-
OCV39_RS06410	1343781..1344089	+	309	WP_261889322.1	transposase	-
OCV39_RS06415	1344086..1344937	+	852	WP_261889306.1	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1200955..1350280	149325
	-	flank	IS/Tn	-	-	1336340..1337296	956

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10295.69 Da
• Isoelectric Point: 8.8578

>T40311 WP_113795376.1 NZ_AP025472:1340723-1340986 [Vibrio cortegadensis]
MSNRLLAWTDEAWDSYVYWQGQDKKTLKRINKLINDVKRSPFDGIGKPEPLKENLTGFWSRRIDDSNRLVYAIDDGVITI
ISCRYHY

Nucleotide

• Length: 264 bp

>T40311 NZ_AP025472:1340723-1340986 [Vibrio cortegadensis]
ATGAGTAATCGTCTATTAGCTTGGACCGATGAGGCTTGGGATAGTTATGTTTATTGGCAGGGGCAGGATAAAAAAACGCT
TAAGCGAATTAACAAGCTCATTAATGATGTTAAACGTTCGCCTTTTGATGGTATCGGTAAACCGGAGCCATTAAAGGAAA
ATTTAACAGGTTTTTGGTCTCGCCGAATTGATGATTCAAATCGTCTTGTTTATGCGATTGATGATGGAGTGATTACAATT
ATTTCGTGCAGATATCATTACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9455.72 Da
• Isoelectric Point: 4.7377

>AT40311 WP_113795377.1 NZ_AP025472:1340476-1340730 [Vibrio cortegadensis]
MRIVSFTEARNGLKAVLDGVVNDADATVITRRDSEDAVVMSLDYYNSLMETIYLMRSPANAEHLNKSIAQYKAGKVIQRD
IFDE

Nucleotide

• Length: 255 bp

>AT40311 NZ_AP025472:1340476-1340730 [Vibrio cortegadensis]
ATGAGAATTGTCTCTTTCACAGAAGCTAGAAATGGTTTGAAAGCCGTTCTTGATGGTGTAGTTAATGATGCGGATGCAAC
AGTAATCACTCGTAGAGATTCTGAAGATGCGGTAGTAATGTCGCTGGATTATTACAATAGCTTAATGGAAACCATTTATT
TAATGCGCTCTCCTGCTAATGCAGAGCATTTAAATAAATCTATCGCTCAATACAAAGCGGGTAAAGTAATACAGCGAGAT
ATTTTCGATGAGTAA