Detailed information of TA system TA040310

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1318822..1319350
• Replicon: chromosome
• Accession: NZ_AP025472
• Organism: Vibrio cortegadensis strain CECT 7227

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7Y4AHY5
• Locus tag: OCV39_RS06220
• Protein ID: WP_053302227.1
• Coordinates: 1318822..1319112 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: OCV39_RS06225
• Protein ID: WP_171757608.1
• Coordinates: 1319102..1319350 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV39_RS06180	1314357..1315067	+	711	WP_261889291.1	HAD family hydrolase	-
OCV39_RS06185	1315790..1316098	-	309	WP_261889485.1	thiamine-binding protein	-
OCV39_RS06190	1316328..1316597	-	270	WP_017054631.1	type II toxin-antitoxin system YafQ family toxin	-
OCV39_RS06195	1316590..1316868	-	279	WP_017054632.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
OCV39_RS06200	1317080..1317457	+	378	WP_017054357.1	PH domain-containing protein	-
OCV39_RS06205	1317596..1317988	+	393	WP_261889292.1	NUDIX domain-containing protein	-
OCV39_RS06210	1318137..1318685	+	549	WP_261889293.1	hypothetical protein	-
OCV39_RS06215	1318675..1318800	+	126	WP_261889294.1	DUF3265 domain-containing protein	-
OCV39_RS06220	1318822..1319112	-	291	WP_053302227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV39_RS06225	1319102..1319350	-	249	WP_171757608.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCV39_RS06230	1319546..1320163	+	618	WP_261889295.1	hypothetical protein	-
OCV39_RS06235	1320371..1320850	+	480	WP_261889296.1	hypothetical protein	-
OCV39_RS06240	1321564..1322100	+	537	WP_261889297.1	nucleotidyltransferase family protein	-
OCV39_RS06245	1322803..1323288	+	486	WP_261889298.1	hypothetical protein	-
OCV39_RS06250	1323321..1324276	-	956	Protein_1200	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1200955..1350280	149325
	-	flank	IS/Tn	-	-	1323321..1323938	617

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-76)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11275.28 Da
• Isoelectric Point: 10.5932

>T40310 WP_053302227.1 NZ_AP025472:c1319112-1318822 [Vibrio cortegadensis]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHIPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T40310 NZ_AP025472:c1319112-1318822 [Vibrio cortegadensis]
ATGACCTATAAGCTTGATTTCAAAAAGAGCGCACTCAAAGAGTGGAAGAAACTCGGATCGACTTTACAACAGCAATTCAA
GAAAAAGCTGATTGAGCGTTTAGACAACCCACATATACCTGCTTCCAAACTCTCTGGCGCAGATAACATGTATAAAATCA
AACTACGTCAATCAGGTTATCGCTTAGTATACAAAGTTGAGGATGACGTAATCATAGTAACCGTCTTAGCTGTAGGCAAA
CGTGAACGAAGCGATGTTTACCGTAAGGCTATGAAAAGACTAGATGATTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9135.47 Da
• Isoelectric Point: 3.9610

>AT40310 WP_171757608.1 NZ_AP025472:c1319350-1319102 [Vibrio cortegadensis]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLTIAKERELEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT40310 NZ_AP025472:c1319350-1319102 [Vibrio cortegadensis]
ATGACCACTAGAATCTTAGCCGATGTTGCTGCAAGTATAACTGAACTAAAAGCAAACCCAATGAAAGTTGCTACTAGCGC
TTATGGTGAACCTGTTGCTGTACTCAATCGAAATGAACCCGCCTTCTATTGCGTTCCAGCCGAAGCATACGAAATGATGA
TGGACAGACTCGAAGATCTTGAGCTACTTACAATAGCAAAAGAACGCGAATTAGAAGAGAGTATTTCGGTAAATATTGAT
GACCTATAA

Structures

Toxin

• AlphaFold DB: A0A7Y4AHY5