Detailed information of TA system TA040309

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1316328..1316868
• Replicon: chromosome
• Accession: NZ_AP025472
• Organism: Vibrio cortegadensis strain CECT 7227

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1E5CN39
• Locus tag: OCV39_RS06190
• Protein ID: WP_017054631.1
• Coordinates: 1316328..1316597 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1E5CN81
• Locus tag: OCV39_RS06195
• Protein ID: WP_017054632.1
• Coordinates: 1316590..1316868 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV39_RS06165	1311461..1312396	+	936	WP_261889289.1	hypothetical protein	-
OCV39_RS06170	1312511..1312912	+	402	WP_261889484.1	GFA family protein	-
OCV39_RS06175	1313741..1314166	+	426	WP_261889290.1	hypothetical protein	-
OCV39_RS06180	1314357..1315067	+	711	WP_261889291.1	HAD family hydrolase	-
OCV39_RS06185	1315790..1316098	-	309	WP_261889485.1	thiamine-binding protein	-
OCV39_RS06190	1316328..1316597	-	270	WP_017054631.1	type II toxin-antitoxin system YafQ family toxin	Toxin
OCV39_RS06195	1316590..1316868	-	279	WP_017054632.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
OCV39_RS06200	1317080..1317457	+	378	WP_017054357.1	PH domain-containing protein	-
OCV39_RS06205	1317596..1317988	+	393	WP_261889292.1	NUDIX domain-containing protein	-
OCV39_RS06210	1318137..1318685	+	549	WP_261889293.1	hypothetical protein	-
OCV39_RS06215	1318675..1318800	+	126	WP_261889294.1	DUF3265 domain-containing protein	-
OCV39_RS06220	1318822..1319112	-	291	WP_053302227.1	type II toxin-antitoxin system RelE/ParE family toxin	-
OCV39_RS06225	1319102..1319350	-	249	WP_171757608.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
OCV39_RS06230	1319546..1320163	+	618	WP_261889295.1	hypothetical protein	-
OCV39_RS06235	1320371..1320850	+	480	WP_261889296.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1200955..1350280	149325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-84)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10363.00 Da
• Isoelectric Point: 8.0503

>T40309 WP_017054631.1 NZ_AP025472:c1316597-1316328 [Vibrio cortegadensis]
MYNLEYSTQFKKDFKKVTKMPIQDILEVGNIISKLQRGETLDPKNVDHPLTGNWVGFRDCHIKPDLVLIYRIFDAQLQLA
RIGSHSDLF

Nucleotide

• Length: 270 bp

>T40309 NZ_AP025472:c1316597-1316328 [Vibrio cortegadensis]
ATGTATAATCTTGAATACTCGACACAATTTAAGAAAGACTTCAAAAAAGTTACAAAGATGCCAATCCAAGACATACTTGA
AGTTGGAAATATCATTTCCAAGCTTCAACGCGGTGAAACTTTAGACCCCAAAAATGTCGATCATCCACTTACTGGTAACT
GGGTCGGGTTTCGAGACTGTCATATAAAACCTGATTTAGTTTTGATATATCGTATTTTTGACGCACAACTTCAGTTAGCA
AGAATTGGCTCACATAGTGACTTGTTCTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 9921.22 Da
• Isoelectric Point: 5.0496

>AT40309 WP_017054632.1 NZ_AP025472:c1316868-1316590 [Vibrio cortegadensis]
MRNEMLSTRIDHDTKAAFTSICDEVGLSTSQAIKLFAKAVINHGGIPFDLRVPQPNNVTAEAIQQLVEGNGHKAESVESM
LAELTEGKVSNV

Nucleotide

• Length: 279 bp

>AT40309 NZ_AP025472:c1316868-1316590 [Vibrio cortegadensis]
ATGAGAAATGAAATGCTTAGCACTCGTATTGATCACGATACAAAAGCAGCTTTTACAAGCATTTGTGATGAAGTTGGTTT
GAGTACATCACAAGCTATCAAACTATTTGCCAAGGCTGTAATTAATCATGGCGGTATTCCGTTCGATCTAAGAGTACCAC
AACCTAATAATGTAACAGCGGAAGCTATCCAACAACTTGTTGAAGGTAACGGTCACAAAGCCGAATCGGTTGAATCTATG
CTAGCTGAACTCACGGAAGGTAAAGTTAGCAATGTATAA

Structures

Toxin

• AlphaFold DB: A0A1E5CN39

Antitoxin

• AlphaFold DB: A0A1E5CN81