Detailed information of TA system TA040308

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1306415..1306943
• Replicon: chromosome
• Accession: NZ_AP025472
• Organism: Vibrio cortegadensis strain CECT 7227

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A7Y4AHY5
• Locus tag: OCV39_RS06125
• Protein ID: WP_053302227.1
• Coordinates: 1306415..1306705 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: OCV39_RS06130
• Protein ID: WP_171757608.1
• Coordinates: 1306695..1306943 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV39_RS06095	1301672..1303126	+	1455	WP_261889279.1	caspase family protein	-
OCV39_RS06100	1303325..1303633	+	309	WP_017054517.1	transposase	-
OCV39_RS06105	1303630..1304481	+	852	WP_261889241.1	IS3 family transposase	-
OCV39_RS06110	1304533..1304922	+	390	WP_261889280.1	hypothetical protein	-
OCV39_RS06115	1305076..1305510	+	435	WP_261889281.1	GNAT family N-acetyltransferase	-
OCV39_RS06120	1305664..1306284	+	621	WP_261889282.1	hypothetical protein	-
OCV39_RS06125	1306415..1306705	-	291	WP_053302227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV39_RS06130	1306695..1306943	-	249	WP_171757608.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
OCV39_RS06135	1307140..1307658	+	519	WP_261889283.1	hypothetical protein	-
OCV39_RS06140	1307871..1308002	+	132	WP_261889284.1	hypothetical protein	-
OCV39_RS06145	1308426..1309061	+	636	WP_261889285.1	CatB-related O-acetyltransferase	-
OCV39_RS06150	1309234..1309512	+	279	WP_261889286.1	hypothetical protein	-
OCV39_RS06155	1309775..1309969	+	195	WP_261889287.1	hypothetical protein	-
OCV39_RS06160	1310696..1311283	+	588	WP_261889288.1	DUF1294 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1200955..1350280	149325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-76)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11275.28 Da
• Isoelectric Point: 10.5932

>T40308 WP_053302227.1 NZ_AP025472:c1306705-1306415 [Vibrio cortegadensis]
MTYKLDFKKSALKEWKKLGSTLQQQFKKKLIERLDNPHIPASKLSGADNMYKIKLRQSGYRLVYKVEDDVIIVTVLAVGK
RERSDVYRKAMKRLDD

Nucleotide

• Length: 291 bp

>T40308 NZ_AP025472:c1306705-1306415 [Vibrio cortegadensis]
ATGACCTATAAGCTTGATTTCAAAAAGAGCGCACTCAAAGAGTGGAAGAAACTCGGATCGACTTTACAACAGCAATTCAA
GAAAAAGCTGATTGAGCGTTTAGACAACCCACATATACCTGCTTCCAAACTCTCTGGCGCAGATAACATGTATAAAATCA
AACTACGTCAATCAGGTTATCGCTTAGTATACAAAGTTGAGGATGACGTAATCATAGTAACCGTCTTAGCTGTAGGCAAA
CGTGAACGAAGCGATGTTTACCGTAAGGCTATGAAAAGACTAGATGATTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9135.47 Da
• Isoelectric Point: 3.9610

>AT40308 WP_171757608.1 NZ_AP025472:c1306943-1306695 [Vibrio cortegadensis]
MTTRILADVAASITELKANPMKVATSAYGEPVAVLNRNEPAFYCVPAEAYEMMMDRLEDLELLTIAKERELEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT40308 NZ_AP025472:c1306943-1306695 [Vibrio cortegadensis]
ATGACCACTAGAATCTTAGCCGATGTTGCTGCAAGTATAACTGAACTAAAAGCAAACCCAATGAAAGTTGCTACTAGCGC
TTATGGTGAACCTGTTGCTGTACTCAATCGAAATGAACCCGCCTTCTATTGCGTTCCAGCCGAAGCATACGAAATGATGA
TGGACAGACTCGAAGATCTTGAGCTACTTACAATAGCAAAAGAACGCGAATTAGAAGAGAGTATTTCGGTAAATATTGAT
GACCTATAA

Structures

Toxin

• AlphaFold DB: A0A7Y4AHY5