Detailed information of TA system TA040305

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1282466..1283025
• Replicon: chromosome
• Accession: NZ_AP025472
• Organism: Vibrio cortegadensis strain CECT 7227

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCV39_RS05970
• Protein ID: WP_136996165.1
• Coordinates: 1282466..1282744 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1E5CTZ0
• Locus tag: OCV39_RS05975
• Protein ID: WP_017051427.1
• Coordinates: 1282741..1283025 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV39_RS05925	1277477..1278139	+	663	WP_261889255.1	hypothetical protein	-
OCV39_RS05930	1278266..1278721	+	456	WP_029203407.1	GNAT family N-acetyltransferase	-
OCV39_RS05935	1278862..1279263	-	402	WP_261889256.1	YkgJ family cysteine cluster protein	-
OCV39_RS05940	1279490..1280068	+	579	WP_261889257.1	hypothetical protein	-
OCV39_RS05945	1280225..1280644	+	420	WP_261889258.1	hypothetical protein	-
OCV39_RS05950	1280804..1281334	+	531	WP_261889259.1	HEPN domain-containing protein	-
OCV39_RS05955	1281474..1281887	+	414	WP_261889260.1	hypothetical protein	-
OCV39_RS05960	1282029..1282331	+	303	WP_069507788.1	hypothetical protein	-
OCV39_RS05965	1282349..1282438	+	90	WP_261889483.1	DUF3265 domain-containing protein	-
OCV39_RS05970	1282466..1282744	-	279	WP_136996165.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV39_RS05975	1282741..1283025	-	285	WP_017051427.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
OCV39_RS05980	1283224..1283598	+	375	WP_261889261.1	DUF6232 family protein	-
OCV39_RS05985	1283766..1284533	+	768	WP_261889262.1	GIY-YIG nuclease family protein	-
OCV39_RS05990	1284684..1285193	+	510	WP_261889263.1	ClbS/DfsB family four-helix bundle protein	-
OCV39_RS05995	1285332..1286657	+	1326	WP_261889264.1	hypothetical protein	-
OCV39_RS06000	1286787..1287269	+	483	WP_136996049.1	MazG-related protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1200955..1350280	149325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10891.57 Da
• Isoelectric Point: 4.3430

>T40305 WP_136996165.1 NZ_AP025472:c1282744-1282466 [Vibrio cortegadensis]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDEIIEDKVENLLEQPLMGVQRDGIRGRLLIIPEISMIISYWVDGSIIRVM
RVLHQKQKFPAN

Nucleotide

• Length: 279 bp

>T40305 NZ_AP025472:c1282744-1282466 [Vibrio cortegadensis]
ATGATTTTATGGGAAGAAGAATCATTGAATGATCGTGAGAAAATATTTGAATTTCTTTATGACTTCAACCCTGACGCAGC
TGAAAAGACTGACGAAATCATTGAAGATAAAGTTGAAAACTTACTTGAACAACCTTTAATGGGTGTTCAACGAGATGGTA
TTCGAGGCCGATTACTAATTATCCCCGAAATCTCTATGATCATTTCATACTGGGTCGATGGTTCAATTATTCGTGTAATG
CGAGTTCTACATCAAAAGCAAAAATTTCCTGCAAACTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10997.31 Da
• Isoelectric Point: 8.0774

>AT40305 WP_017051427.1 NZ_AP025472:c1283025-1282741 [Vibrio cortegadensis]
MDTRIQFRIDDEIKRLAQQMAESQGRTLSDACRELTEQMAEQQRKTLSHDSWITEQVNLAFEKFDSGKATFVDHDSAKTR
MAERKAKIRNRGHQ

Nucleotide

• Length: 285 bp

>AT40305 NZ_AP025472:c1283025-1282741 [Vibrio cortegadensis]
ATGGATACTAGAATTCAATTCCGTATTGATGACGAAATTAAACGCTTAGCTCAACAAATGGCGGAGAGCCAAGGTCGTAC
ACTTAGCGATGCTTGCCGTGAGCTTACAGAGCAAATGGCGGAGCAACAACGAAAAACATTATCTCATGACTCTTGGATAA
CTGAACAAGTAAACTTAGCATTTGAGAAATTCGACTCCGGGAAAGCTACATTTGTTGATCATGACTCAGCAAAAACTAGA
ATGGCTGAACGAAAAGCTAAAATTCGCAATCGAGGCCATCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1E5CTZ0