Detailed information of TA system TA040304

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1261783..1262342
• Replicon: chromosome
• Accession: NZ_AP025472
• Organism: Vibrio cortegadensis strain CECT 7227

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: OCV39_RS05830
• Protein ID: WP_261889202.1
• Coordinates: 1261783..1262061 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1E5CTZ0
• Locus tag: OCV39_RS05835
• Protein ID: WP_017051427.1
• Coordinates: 1262058..1262342 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
OCV39_RS05800	1257169..1257516	+	348	WP_261889240.1	cupin domain-containing protein	-
OCV39_RS05805	1257681..1258259	-	579	WP_261889201.1	hypothetical protein	-
OCV39_RS05810	1258512..1259096	+	585	WP_261889200.1	hypothetical protein	-
OCV39_RS05815	1259283..1259591	+	309	WP_017054517.1	transposase	-
OCV39_RS05820	1259588..1260439	+	852	WP_261889241.1	IS3 family transposase	-
OCV39_RS05825	1260915..1261646	+	732	WP_261889199.1	hypothetical protein	-
OCV39_RS05830	1261783..1262061	-	279	WP_261889202.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
OCV39_RS05835	1262058..1262342	-	285	WP_017051427.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
OCV39_RS05840	1262555..1263079	+	525	WP_261889242.1	hypothetical protein	-
OCV39_RS05845	1263424..1263768	+	345	WP_261889243.1	hypothetical protein	-
OCV39_RS05850	1264009..1264356	+	348	WP_261889244.1	DUF3775 domain-containing protein	-
OCV39_RS05855	1265554..1265775	+	222	WP_261889245.1	hypothetical protein	-
OCV39_RS05860	1265847..1266509	+	663	WP_261889246.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1200955..1350280	149325

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-44)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10949.61 Da
• Isoelectric Point: 4.2698

>T40304 WP_261889202.1 NZ_AP025472:c1262061-1261783 [Vibrio cortegadensis]
MILWEEESLNDREKIFEFLYDFNPDAAEKTDEIIEDKVENLLEQPLMGVQRDDIRGRLLIIPEISMIISYWVDGSIIRVM
RVLHQKQKFPAN

Nucleotide

• Length: 279 bp

>T40304 NZ_AP025472:c1262061-1261783 [Vibrio cortegadensis]
ATGATTTTATGGGAAGAAGAATCATTGAATGATCGTGAGAAAATATTTGAATTTCTTTATGACTTCAACCCTGACGCAGC
TGAAAAGACTGACGAAATCATTGAAGATAAAGTTGAAAACTTACTTGAACAACCTTTAATGGGTGTTCAACGAGATGATA
TTCGAGGCCGATTACTAATTATCCCCGAAATCTCTATGATCATTTCATACTGGGTCGATGGTTCAATTATTCGTGTAATG
CGAGTTCTACATCAAAAGCAAAAATTTCCTGCAAACTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10997.31 Da
• Isoelectric Point: 8.0774

>AT40304 WP_017051427.1 NZ_AP025472:c1262342-1262058 [Vibrio cortegadensis]
MDTRIQFRIDDEIKRLAQQMAESQGRTLSDACRELTEQMAEQQRKTLSHDSWITEQVNLAFEKFDSGKATFVDHDSAKTR
MAERKAKIRNRGHQ

Nucleotide

• Length: 285 bp

>AT40304 NZ_AP025472:c1262342-1262058 [Vibrio cortegadensis]
ATGGATACTAGAATTCAATTCCGTATTGATGACGAAATTAAACGCTTAGCTCAACAAATGGCGGAGAGCCAAGGTCGTAC
ACTTAGCGATGCTTGCCGTGAGCTTACAGAGCAAATGGCGGAGCAACAACGAAAAACATTATCTCATGACTCTTGGATAA
CTGAACAAGTAAACTTAGCATTTGAGAAATTCGACTCCGGGAAAGCTACATTTGTTGATCATGACTCAGCAAAAACTAGA
ATGGCTGAACGAAAAGCTAAAATTCGCAATCGAGGCCATCAATGA

Structures

Antitoxin

• AlphaFold DB: A0A1E5CTZ0